YAP7_YEAST
ID YAP7_YEAST Reviewed; 245 AA.
AC Q08182; D6W237;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=AP-1-like transcription factor YAP7;
GN Name=YAP7; OrderedLocusNames=YOL028C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP FUNCTION, AND ISOLATION OF YAP FAMILY PROTEINS.
RX PubMed=9372930; DOI=10.1128/mcb.17.12.6982;
RA Fernandes L., Rodrigues-Pousada C., Struhl K.;
RT "Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae
RT with distinct biological functions.";
RL Mol. Cell. Biol. 17:6982-6993(1997).
RN [5]
RP FUNCTION, AND CELL CYCLE ACTIVATION.
RX PubMed=12518319; DOI=10.1002/yea.938;
RA Munoz I., Simon E., Casals N., Clotet J., Arino J.;
RT "Identification of multicopy suppressors of cell cycle arrest at the G1-S
RT transition in Saccharomyces cerevisiae.";
RL Yeast 20:157-169(2003).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Probable transcription activator linked to cell cycle that
CC induces transcription activation of genes in the environmental stress
CC response and metabolism control pathways, like the closely related
CC YAP5. {ECO:0000269|PubMed:12518319, ECO:0000269|PubMed:9372930}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: One of 8 closely related fungi-specific YAP proteins
CC (YAP1 to YAP8), which all seem to be transcription activators of the
CC environmental stress response and metabolism control pathways and to
CC have similar but not identical DNA binding specificities.
CC -!- MISCELLANEOUS: Present with 1700 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the bZIP family. YAP subfamily. {ECO:0000305}.
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DR EMBL; Z74770; CAA99028.1; -; Genomic_DNA.
DR EMBL; AY558012; AAS56338.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10753.1; -; Genomic_DNA.
DR PIR; S66711; S66711.
DR RefSeq; NP_014614.1; NM_001183282.1.
DR AlphaFoldDB; Q08182; -.
DR SMR; Q08182; -.
DR BioGRID; 34372; 70.
DR DIP; DIP-4935N; -.
DR IntAct; Q08182; 7.
DR MINT; Q08182; -.
DR STRING; 4932.YOL028C; -.
DR iPTMnet; Q08182; -.
DR PaxDb; Q08182; -.
DR PRIDE; Q08182; -.
DR EnsemblFungi; YOL028C_mRNA; YOL028C; YOL028C.
DR GeneID; 854129; -.
DR KEGG; sce:YOL028C; -.
DR SGD; S000005388; YAP7.
DR VEuPathDB; FungiDB:YOL028C; -.
DR eggNOG; ENOG502SAAA; Eukaryota.
DR HOGENOM; CLU_077482_0_0_1; -.
DR InParanoid; Q08182; -.
DR OMA; NWELPQR; -.
DR BioCyc; YEAST:G3O-33444-MON; -.
DR PRO; PR:Q08182; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q08182; protein.
DR GO; GO:0005634; C:nucleus; ISS:SGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:SGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:SGD.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR018287; Hap4_TF_heteromerisation.
DR Pfam; PF00170; bZIP_1; 1.
DR Pfam; PF10297; Hap4_Hap_bind; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..245
FT /note="AP-1-like transcription factor YAP7"
FT /id="PRO_0000076527"
FT DOMAIN 125..188
FT /note="bZIP"
FT REGION 1..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..149
FT /note="Basic motif"
FT /evidence="ECO:0000250"
FT REGION 153..181
FT /note="Leucine-zipper"
FT /evidence="ECO:0000250"
FT COMPBIAS 22..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 245 AA; 27387 MW; EBA1C0C0E868E45C CRC64;
MRQRRSVVAV SVKPKGFKLG HKQGSMSTTS PPPSSPDGNV STSGPSAIKL SKNWELPQRL
KPGRKPKSKR GDASANNDGS SKIKKVQTSN QKDQMTTKDH ENEGAKGHEG KSDDEGNGSG
DENGVDSVEK RRRQNRDAQR AYRERRTTRI QVLEEKVEML HNLVDDWQRK YKLLESEFSD
TKENLQKSIA LNNELQKALP LIVNTPFQQQ PENPPDNPIS ILEMVENFKP IGAVSLKKGK
LKAHC
