ID   YAY8_SCHPO              Reviewed;         286 AA.
AC   Q10216;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Uncharacterized oxidoreductase C4H3.08;
DE            EC=1.-.-.-;
GN   ORFNames=SPAC4H3.08;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; CU329670; CAA93347.1; -; Genomic_DNA.
DR   PIR; T38888; T38888.
DR   RefSeq; NP_594344.1; NM_001019765.2.
DR   AlphaFoldDB; Q10216; -.
DR   SMR; Q10216; -.
DR   BioGRID; 279788; 2.
DR   STRING; 4896.SPAC4H3.08.1; -.
DR   iPTMnet; Q10216; -.
DR   MaxQB; Q10216; -.
DR   PaxDb; Q10216; -.
DR   EnsemblFungi; SPAC4H3.08.1; SPAC4H3.08.1:pep; SPAC4H3.08.
DR   GeneID; 2543366; -.
DR   KEGG; spo:SPAC4H3.08; -.
DR   PomBase; SPAC4H3.08; -.
DR   VEuPathDB; FungiDB:SPAC4H3.08; -.
DR   eggNOG; KOG0725; Eukaryota.
DR   HOGENOM; CLU_010194_4_1_1; -.
DR   InParanoid; Q10216; -.
DR   OMA; WEVANVI; -.
DR   PhylomeDB; Q10216; -.
DR   PRO; PR:Q10216; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; ISO:PomBase.
DR   GO; GO:0006631; P:fatty acid metabolic process; ISS:PomBase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..286
FT                   /note="Uncharacterized oxidoreductase C4H3.08"
FT                   /id="PRO_0000054875"
FT   ACT_SITE        192
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         46..70
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         179
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   286 AA;  31336 MW;  53BBF52B9A854B0D CRC64;
     MDPVPSTQTQ KWPGKHADLD PEPSLLRYCD GRVHVGSGKL AEKKTLLTGG DSGIGKAAAV
     MFAREGSDLV ISCLPEERDD AEVTRDLIER EGRNCWIWEG KLDKSDNCRD LVDFALKKLG
     WIDVLVNNIA YQQVAQSIED IDDEQWDLTF KTNIFSFFWV TKAAISHMKS GSSIVNCSSI
     NAYVGRPDLL DYTSTKGAIT AFTRGLSNQY AQHGIRVNAV APGPIYTPLV SSTFPKEKIE
     LSDQVPLGRM GQPVEVASCY LFLACSDGGY MTGQTLHPNG GTVINN