ID   YB45_SCHPO              Reviewed;         247 AA.
AC   O14351;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Uncharacterized oxidoreductase C30D10.05c;
DE            EC=1.-.-.-;
GN   ORFNames=SPBC30D10.05c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; CU329671; CAB10800.1; -; Genomic_DNA.
DR   PIR; T40191; T40191.
DR   RefSeq; NP_596280.1; NM_001022201.2.
DR   AlphaFoldDB; O14351; -.
DR   SMR; O14351; -.
DR   BioGRID; 276930; 9.
DR   STRING; 4896.SPBC30D10.05c.1; -.
DR   iPTMnet; O14351; -.
DR   MaxQB; O14351; -.
DR   PaxDb; O14351; -.
DR   PRIDE; O14351; -.
DR   EnsemblFungi; SPBC30D10.05c.1; SPBC30D10.05c.1:pep; SPBC30D10.05c.
DR   GeneID; 2540402; -.
DR   KEGG; spo:SPBC30D10.05c; -.
DR   PomBase; SPBC30D10.05c; -.
DR   VEuPathDB; FungiDB:SPBC30D10.05c; -.
DR   eggNOG; KOG1204; Eukaryota.
DR   HOGENOM; CLU_010194_2_11_1; -.
DR   InParanoid; O14351; -.
DR   OMA; INNAGWI; -.
DR   PhylomeDB; O14351; -.
DR   PRO; PR:O14351; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0050664; F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor; IBA:GO_Central.
DR   GO; GO:0004757; F:sepiapterin reductase activity; ISS:PomBase.
DR   GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; ISS:PomBase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..247
FT                   /note="Uncharacterized oxidoreductase C30D10.05c"
FT                   /id="PRO_0000054876"
FT   ACT_SITE        150
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         10..31
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         137
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   247 AA;  26645 MW;  A7532E8DDC7C5608 CRC64;
     MAETAEKVIL LTGSSKGIGL ATAEALQKKA KVIAVSRSLT PELETLLIQN PDSFVHVKGD
     VTEVGKASIE TAIKKFGKLD SVILNAGVLE PIAKIADADI NEWRKLFDIN FFSVVETVKY
     AIPHLRKTKG TIVIVSSGAA VRVFPAWAAY CCSKAAINML VMNLGSEEPD IMSVAVRPGV
     VDTPMQVSIR NDSNKEAMGG DTHNFFKELK TSGQLVAPQD IAKALSFLAL NNNPKLTGQF
     VEWKSFV