YB63_SCHPO
ID YB63_SCHPO Reviewed; 571 AA.
AC Q09744;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Uncharacterized FAD-binding protein C12C2.03c;
GN ORFNames=SPBC12C2.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the flavoprotein pyridine nucleotide cytochrome
CC reductase family. {ECO:0000305}.
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DR EMBL; CU329671; CAA90816.1; -; Genomic_DNA.
DR PIR; T39378; T39378.
DR RefSeq; NP_596020.1; NM_001021928.2.
DR AlphaFoldDB; Q09744; -.
DR SMR; Q09744; -.
DR BioGRID; 276688; 25.
DR STRING; 4896.SPBC12C2.03c.1; -.
DR iPTMnet; Q09744; -.
DR MaxQB; Q09744; -.
DR PaxDb; Q09744; -.
DR PRIDE; Q09744; -.
DR EnsemblFungi; SPBC12C2.03c.1; SPBC12C2.03c.1:pep; SPBC12C2.03c.
DR GeneID; 2540152; -.
DR KEGG; spo:SPBC12C2.03c; -.
DR PomBase; SPBC12C2.03c; -.
DR VEuPathDB; FungiDB:SPBC12C2.03c; -.
DR eggNOG; KOG1158; Eukaryota.
DR HOGENOM; CLU_001570_17_5_1; -.
DR InParanoid; Q09744; -.
DR OMA; LCCGGGC; -.
DR PhylomeDB; Q09744; -.
DR Reactome; R-SPO-1222556; ROS and RNS production in phagocytes.
DR Reactome; R-SPO-1474151; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
DR Reactome; R-SPO-203615; eNOS activation.
DR Reactome; R-SPO-392154; Nitric oxide stimulates guanylate cyclase.
DR Reactome; R-SPO-5218920; VEGFR2 mediated vascular permeability.
DR Reactome; R-SPO-5578775; Ion homeostasis.
DR Reactome; R-SPO-9009391; Extra-nuclear estrogen signaling.
DR Reactome; R-SPO-9033241; Peroxisomal protein import.
DR PRO; PR:Q09744; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0030586; F:[methionine synthase] reductase activity; ISS:PomBase.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; ISM:PomBase.
DR GO; GO:0010181; F:FMN binding; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0050667; P:homocysteine metabolic process; IBA:GO_Central.
DR GO; GO:0009086; P:methionine biosynthetic process; ISS:PomBase.
DR Gene3D; 1.20.990.10; -; 1.
DR Gene3D; 3.40.50.80; -; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; SSF52343; 1.
DR SUPFAM; SSF63380; SSF63380; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT CHAIN 1..571
FT /note="Uncharacterized FAD-binding protein C12C2.03c"
FT /id="PRO_0000167630"
FT DOMAIN 135..389
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00716"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 571 AA; 63977 MW; D2EE992789307249 CRC64;
MAPSVATSLK AEILPSPRTS SPSSNFKTCV SNENGCINCR CSPSEPHESA NVDESVNKLS
KTFSKLSLNP TFQALNMDLG LLHENITLDR IPKVPENHVS LIDIDEARAK EDPNFQIHST
PSRMPPHYVQ PHPPFSVFPA PILDVRELTK PGAVKRVFHF ELDVSNYPLP EGEEWMVGGS
FGVMAPNNEE DVDELLQLLH INPDQADAPV LLKTDGGRWP TIWAEDTPRE LVTTRRELLK
WTVEFMSVAP KKQLIRLLAE YAKDDTERQV LLFLVSRLGQ RAFCDLRDHN VTLITLLKAF
PSVQLPLDHL LTVLPQLMPR WYSLSNDPKV SNNVLEFAVT VVEINKVEGG TRSGIGSGFL
KRLALRFLNG ERDLVLPMYR GLHKNAFATH FASDGPMCLI GAGVGVAPFR GFVQRRLTNA
TCAGKVWVFH GCRDQELDEL YHGEWENPLQ KSSDDDASST VSQQTETEMD SFEVKKDGTS
GPNHLVVESR SHQHAYVQDE IRHRGDIVWS VLSHPHGKVY LCGGKKGFLD GVENALIDVC
VQYGKMSRLE ATQQLALWQS PLNLKYIKEI W
