YB70_YEAST
ID YB70_YEAST Reviewed; 560 AA.
AC P38318; D6VQL6;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Uncharacterized membrane protein YBR220C;
GN OrderedLocusNames=YBR220C; ORFNames=YBR1510;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
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DR EMBL; Z36088; CAA85183.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07336.1; -; Genomic_DNA.
DR PIR; S46096; S46096.
DR RefSeq; NP_009779.3; NM_001178568.3.
DR AlphaFoldDB; P38318; -.
DR BioGRID; 32917; 67.
DR DIP; DIP-5702N; -.
DR IntAct; P38318; 1.
DR STRING; 4932.YBR220C; -.
DR TCDB; 2.A.1.25.4; the major facilitator superfamily (mfs).
DR iPTMnet; P38318; -.
DR MaxQB; P38318; -.
DR PaxDb; P38318; -.
DR PRIDE; P38318; -.
DR EnsemblFungi; YBR220C_mRNA; YBR220C; YBR220C.
DR GeneID; 852521; -.
DR KEGG; sce:YBR220C; -.
DR SGD; S000000424; YBR220C.
DR VEuPathDB; FungiDB:YBR220C; -.
DR eggNOG; KOG3574; Eukaryota.
DR GeneTree; ENSGT00940000154019; -.
DR HOGENOM; CLU_020502_1_1_1; -.
DR InParanoid; P38318; -.
DR OMA; LWFWGIT; -.
DR BioCyc; YEAST:G3O-29156-MON; -.
DR Reactome; R-SCE-425397; Transport of vitamins, nucleosides, and related molecules.
DR PRO; PR:P38318; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38318; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008521; F:acetyl-CoA transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015295; F:solute:proton symporter activity; IBA:GO_Central.
DR InterPro; IPR024371; AcetylCoA_trans_1-like.
DR InterPro; IPR004752; AmpG_permease/AT-1.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR12778; PTHR12778; 1.
DR Pfam; PF13000; Acatn; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..560
FT /note="Uncharacterized membrane protein YBR220C"
FT /id="PRO_0000202514"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..54
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..88
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..139
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..214
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..329
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 351..374
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 396..421
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 443..521
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 543..560
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 560 AA; 63010 MW; D10A20FA041B5DF3 CRC64;
MEPKRKSGSL AKHDLPQFYL LIMLYLAQGI PVGLAFGTVP FLLKSLAKET SFTSLGIFSM
ATYPYSLKII WSPIVDSLYN KRIGRRRSWI IPVQFVSGFV LWALGWCISQ GIIFDGVDDA
FHNRGNGTLH SVSIKNLTWW FGLLVFLCAT QDIAVDGWAL TILSKESLSY ASTAQTIGLN
IGYFMSFTIF LSLNSSDFAN KYFRNIPLDH GFISLGGYMK FSGMLYIVIT IYIIFCTKEK
PYVEYLPKVE PINTSDGGSK PISIEYDDGD VVSTQNTSSI KYIYRCFIKV LKLKSVRSLA
FIHMISKFAF QCNEAATNLK LLEQGFKRED LAVTVLIDLP FEIIFGYYVV KWSSDKDPMI
RDNRRLRNST GTNKVIKFLV GDAGVLTPWL WGFLGRLAAA VLGSYVVKQF PKDGEISTGY
FCLVIFQHLL GSFMNTVQFI GISAFHTRVA DPVLGGTYMT LLNTLSNFGG TWPRLIIMSM
INYFTVYQCT IPGTNKVYVT HGGSMQACTE LLNGTVTILR DGYYITNLIC IVVGLFLYFG
YLKRKILHLQ SLPISSWRCT
