YB91_YEAST
ID YB91_YEAST Reviewed; 488 AA.
AC P38142; D6VQN7; Q6B2Y5;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Probable metabolite transport protein YBR241C;
GN OrderedLocusNames=YBR241C; ORFNames=YBR1625;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:14562095};
CC Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; Z36110; CAA85204.1; -; Genomic_DNA.
DR EMBL; AY692595; AAT92614.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07357.1; -; Genomic_DNA.
DR PIR; S46118; S46118.
DR RefSeq; NP_009800.1; NM_001178589.1.
DR AlphaFoldDB; P38142; -.
DR SMR; P38142; -.
DR BioGRID; 32936; 33.
DR DIP; DIP-5363N; -.
DR IntAct; P38142; 10.
DR MINT; P38142; -.
DR STRING; 4932.YBR241C; -.
DR TCDB; 2.A.1.1.96; the major facilitator superfamily (mfs).
DR PaxDb; P38142; -.
DR PRIDE; P38142; -.
DR EnsemblFungi; YBR241C_mRNA; YBR241C; YBR241C.
DR GeneID; 852543; -.
DR KEGG; sce:YBR241C; -.
DR SGD; S000000445; YBR241C.
DR VEuPathDB; FungiDB:YBR241C; -.
DR eggNOG; KOG0569; Eukaryota.
DR GeneTree; ENSGT00940000166877; -.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; P38142; -.
DR OMA; PQCIPMN; -.
DR BioCyc; YEAST:G3O-29172-MON; -.
DR Reactome; R-SCE-189200; Cellular hexose transport.
DR Reactome; R-SCE-196836; Vitamin C (ascorbate) metabolism.
DR Reactome; R-SCE-422356; Regulation of insulin secretion.
DR Reactome; R-SCE-5653890; Lactose synthesis.
DR Reactome; R-SCE-6798695; Neutrophil degranulation.
DR Reactome; R-SCE-8981373; Intestinal hexose absorption.
DR PRO; PR:P38142; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38142; protein.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015149; F:hexose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; ISS:SGD.
DR GO; GO:0015749; P:monosaccharide transmembrane transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; ISS:SGD.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR045263; GLUT.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR23503; PTHR23503; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..488
FT /note="Probable metabolite transport protein YBR241C"
FT /id="PRO_0000050463"
FT TOPO_DOM 1..18
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 19..39
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 40..87
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..121
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143..146
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..178
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..198
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..204
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..299
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 321..322
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..337
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 338..344
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..364
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 365..390
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 412..419
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 420..442
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 443..446
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..463
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 464..488
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 258..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 438
FT /note="V -> A (in Ref. 3; AAT92614)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 488 AA; 53526 MW; F74A2E3676363BE5 CRC64;
MAETERLMPN GGSRETKPLI TGHLILGTIV ACLGSIQYGY HIAELNAPQE FLSCSRFEAP
DENISYDDTW VGQHGLKQCI ALTDSQYGAI TSIFSIGGLF GSYYAGNWAN RYGRKYVSMG
ASAMCMVSSL LLFFSNSYLQ LLFGRFLVGM SCGTAIVITP LFINEIAPVE WRGAMGSMNQ
VSINLGILLT QTLALKYADS YNWRWLLFSG SVIAVANILA WLKVDESPRW LVSHGFVSEA
ETALFKLRPG TYQQAKQEIQ DWQRSHGHNR DPESSEETHS GPTLWQYVTD PSYKKPRTVI
LAILSCQQFC GINSIIFYGV KVIGKILPDY SIQVNFAISI LNVVVTLAAS AIIDHVGRRP
LLLASTTVMT AMSLLISVGL TLSVSFLLVT ATFVYIAAFA IGLGPIPFLI IGELSYPQDA
ATAQSFGTVC NWLATFIVGY LFPIGHGLMG GYVFAIFAAI AAMFATYVYK RVPETKGKTT
YSEVWAGY
