YB9Z_YEAST
ID YB9Z_YEAST Reviewed; 797 AA.
AC P38150; D6VQS9;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Inactive deaminase YBR284W;
GN OrderedLocusNames=YBR284W; ORFNames=YBR2021;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091861; DOI=10.1002/yea.320100007;
RA Holmstroem K., Brandt T., Kallesoe T.;
RT "The sequence of a 32,420 bp segment located on the right arm of chromosome
RT II from Saccharomyces cerevisiae.";
RL Yeast 10:S47-S62(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000305}.
CC -!- CAUTION: Lacks the conserved His residues essential for binding the
CC catalytic zinc ion. Its enzyme activity is therefore unsure.
CC {ECO:0000305}.
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DR EMBL; X76053; CAA53647.1; -; Genomic_DNA.
DR EMBL; Z36153; CAA85248.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07399.1; -; Genomic_DNA.
DR PIR; S44546; S44546.
DR RefSeq; NP_009843.3; NM_001178632.3.
DR AlphaFoldDB; P38150; -.
DR SMR; P38150; -.
DR BioGRID; 32978; 64.
DR DIP; DIP-1257N; -.
DR IntAct; P38150; 4.
DR MINT; P38150; -.
DR STRING; 4932.YBR284W; -.
DR PaxDb; P38150; -.
DR PRIDE; P38150; -.
DR EnsemblFungi; YBR284W_mRNA; YBR284W; YBR284W.
DR GeneID; 852587; -.
DR KEGG; sce:YBR284W; -.
DR SGD; S000000488; YBR284W.
DR VEuPathDB; FungiDB:YBR284W; -.
DR eggNOG; KOG1096; Eukaryota.
DR GeneTree; ENSGT00950000183011; -.
DR HOGENOM; CLU_003782_2_0_1; -.
DR InParanoid; P38150; -.
DR BioCyc; YEAST:G3O-29204-MON; -.
DR Reactome; R-SCE-6798695; Neutrophil degranulation.
DR Reactome; R-SCE-74217; Purine salvage.
DR PRO; PR:P38150; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38150; protein.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046483; P:heterocycle metabolic process; IEA:UniProt.
DR GO; GO:1901360; P:organic cyclic compound metabolic process; IEA:UniProt.
DR InterPro; IPR006329; AMPD.
DR InterPro; IPR032466; Metal_Hydrolase.
DR PANTHER; PTHR11359; PTHR11359; 2.
DR Pfam; PF19326; AMP_deaminase; 1.
DR PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR SUPFAM; SSF51556; SSF51556; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..797
FT /note="Inactive deaminase YBR284W"
FT /id="PRO_0000194415"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 797 AA; 92904 MW; BF854E93D0B2C747 CRC64;
MVQNNESVFF VECDSYKESP STSPIRLDDL DGNDAVSDQG LAFDGDVGIT SQARVRNPRA
QIFEDSNTDV VLHLDDLDMV PLNTKFDMQM EMGSPMAMPA ETPPPVEPLK TKDLAYSSLA
HLPSYFFEQT HFRIDRKCLL EMSKLRRNYL TISKQDALSC PQLHSRVAGG YLKPVKEKLF
GIRHFLDLEE SNTVNLLQDG NYMTELFNSQ INIPTFKEFR EDFEWCLKII RDRSLSRFSE
KRLQYLVNKF PVFQHLHSKE EMRQSKKVPH KDFYNCRKID LNLLLSGCFS QWQLTEFIWT
KLRKEPDRVI HQAFNGSHIT LSQLFKVNFE ETGQFFNGLK IIDDSFLEWY KVIYLAKYHL
VNDEMEIHTG SHGKQLRYYL IAKTFLEFDN YINGEYLAEL LKTFLIKPQE ESKYQLCQLS
VDFQFYLHYD NSDVDNWWMV FANWLNHYNI FSNNIRWNIR ISRIYPELYH TGKVKNFQEY
LNLIFKPLFN AENYLHKSLG PILLKFLSQV SSIDLCIQDT DNYIWKNFTA VSCLPKDWTS
GGDNPTISQY MYYVYVNLTK LNHIRQALHQ NTFTLRSSCS PTSMNRTSQF SNTLNFTEHT
EAILNNFLLA CGGFLNAENL WNAPPSLVYL FYLSQIPMVV APLNSIVDSK PTMLQEQAPT
GLVLEPSKPY KKNPFMKFFE MGFKISLSSE SILYNNSYTK EPIIEEYSVA ASIYRLHSAD
LCELLRNSVI TSGFSSTLKN KWLGVSLASH DYFVENTGFV DKWYDCKPNT SLEHNVPIIR
RQYRSSTLAG EWRLIIA
