CATIN_CAEEL
ID CATIN_CAEEL Reviewed; 657 AA.
AC G5EG14; E5QCI6; E5QCI7;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Cactin;
GN Name=cacn-1; ORFNames=W03H9.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=20188721; DOI=10.1016/j.ydbio.2010.02.025;
RA Tannoury H., Rodriguez V., Kovacevic I., Ibourk M., Lee M., Cram E.J.;
RT "CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling to control
RT distal tip cell migration in C. elegans.";
RL Dev. Biol. 341:176-185(2010).
CC -!- FUNCTION: Plays a role during early embryonic development. Required for
CC the distal tip cell migration at the end of larval development and for
CC gonad morphogenesis. {ECO:0000269|PubMed:20188721}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20188721}. Cytoplasm
CC {ECO:0000269|PubMed:20188721}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a;
CC IsoId=G5EG14-1; Sequence=Displayed;
CC Name=b;
CC IsoId=G5EG14-2; Sequence=VSP_044144;
CC Name=c;
CC IsoId=G5EG14-3; Sequence=VSP_044143;
CC -!- TISSUE SPECIFICITY: Expressed in pharynx, intestine, vulva and
CC spermatheca (at protein level). {ECO:0000269|PubMed:20188721}.
CC -!- DEVELOPMENTAL STAGE: Expressed in migrating distal tip cells throughout
CC larval development (at protein level). {ECO:0000269|PubMed:20188721}.
CC -!- SIMILARITY: Belongs to the CACTIN family. {ECO:0000305}.
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DR EMBL; Z82067; CAB76738.2; -; Genomic_DNA.
DR EMBL; Z83234; CAB76738.2; JOINED; Genomic_DNA.
DR EMBL; Z83234; CBY25190.2; -; Genomic_DNA.
DR EMBL; Z83234; CBY25191.1; -; Genomic_DNA.
DR RefSeq; NP_001254420.1; NM_001267491.1. [G5EG14-2]
DR RefSeq; NP_001254421.1; NM_001267492.1. [G5EG14-3]
DR RefSeq; NP_001254422.1; NM_001267493.1. [G5EG14-1]
DR AlphaFoldDB; G5EG14; -.
DR SMR; G5EG14; -.
DR BioGRID; 40348; 1.
DR IntAct; G5EG14; 1.
DR STRING; 6239.W03H9.4a; -.
DR EPD; G5EG14; -.
DR PaxDb; G5EG14; -.
DR PeptideAtlas; G5EG14; -.
DR PRIDE; G5EG14; -.
DR EnsemblMetazoa; W03H9.4a.1; W03H9.4a.1; WBGene00012230. [G5EG14-1]
DR EnsemblMetazoa; W03H9.4b.1; W03H9.4b.1; WBGene00012230. [G5EG14-2]
DR EnsemblMetazoa; W03H9.4c.1; W03H9.4c.1; WBGene00012230. [G5EG14-3]
DR GeneID; 175066; -.
DR KEGG; cel:CELE_W03H9.4; -.
DR CTD; 175066; -.
DR WormBase; W03H9.4a; CE46363; WBGene00012230; cacn-1. [G5EG14-1]
DR WormBase; W03H9.4b; CE46257; WBGene00012230; cacn-1. [G5EG14-2]
DR WormBase; W03H9.4c; CE45519; WBGene00012230; cacn-1. [G5EG14-3]
DR eggNOG; KOG2370; Eukaryota.
DR GeneTree; ENSGT00950000183102; -.
DR HOGENOM; CLU_011759_0_0_1; -.
DR InParanoid; G5EG14; -.
DR OMA; HEPYMLL; -.
DR OrthoDB; 1252926at2759; -.
DR PhylomeDB; G5EG14; -.
DR PRO; PR:G5EG14; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00012230; Expressed in adult organism and 8 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005681; C:spliceosomal complex; IDA:WormBase.
DR GO; GO:0003723; F:RNA binding; ISS:WormBase.
DR GO; GO:0008406; P:gonad development; IMP:UniProtKB.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB.
DR GO; GO:0030334; P:regulation of cell migration; IMP:WormBase.
DR GO; GO:0010468; P:regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0030111; P:regulation of Wnt signaling pathway; IMP:WormBase.
DR InterPro; IPR019134; Cactin_C.
DR InterPro; IPR018816; Cactin_central.
DR Pfam; PF10312; Cactin_mid; 1.
DR Pfam; PF09732; CactinC_cactus; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Developmental protein;
KW Nucleus; Reference proteome.
FT CHAIN 1..657
FT /note="Cactin"
FT /id="PRO_0000419267"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 23..77
FT /evidence="ECO:0000255"
FT COILED 352..403
FT /evidence="ECO:0000255"
FT COMPBIAS 15..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..461
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_044143"
FT VAR_SEQ 1..312
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_044144"
SQ SEQUENCE 657 AA; 77418 MW; D86210EC02C767E2 CRC64;
MGKDSKKHKK ERRRERSPST SDSDEERLQK RLAEQRSLKK DEKRRQKEEM KKNESAEEKR
ARRMEKKMRK DAKRKDADAE DTLIPPELNY TNLNNPFNDT KLTQTFVWGK KLEREGKSGL
TQDEITKQTS QRIRKNLHEA AEFKRIRDSR AAAKEDMEMM KRDADLRAGQ ISDTKEREFQ
MDQIKERTRI RIDQGRAKAI DLLSRYARFA DENPHTAKIP DFELENPMEY LKASCKSVDD
YEDLIEDIKT YREVDGWAKN ETWWMDVTRI AEDEIQKKAA QNRGDVHASV QTEVQNMFKN
KSIDELLKLE DQMDAKIRGN SGNKGYWQDL DDQLKVFIAR KRLREHHGRV LRLQLAIIKE
EQKKEIQQQE SEELLPVAEV PPQVKIQKEE EEEEEEDEDD EKISKKVRRK IDVQTLDDPE
LDEPERERKW RALTGDQLDD VTRELYRIGC YSPTYISADD TMPGIEILDE QADVDNLTER
RNRNRGTLPS SSAASSGAPQ GASSKMMAIA REGMEADESI FGAEEQLAAQ RHLWSDKYRP
RKPTYLNRVQ TGFDWNKYNQ THYDQDNPPP KIVQGYKFNI FYPDLLDMTV APRFGLTSCE
DPDFAIIRFK AGPPYEDIAF KVVNREWETL HKNGYKCQFQ NGVFQLWFMF KKYRYRR
