CATIN_DANRE
ID CATIN_DANRE Reviewed; 835 AA.
AC F1Q8W0; A1L232;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Cactin;
DE Short=zCactin;
GN Name=cactin; ORFNames=si:dkey-158a20.4, zgc:158620;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=20348034; DOI=10.1016/j.gep.2010.03.003;
RA Atzei P., Yang F., Collery R., Kennedy B.N., Moynagh P.N.;
RT "Characterisation of expression patterns and functional role of Cactin in
RT early zebrafish development.";
RL Gene Expr. Patterns 10:199-206(2010).
CC -!- FUNCTION: May be involved in the regulation of innate immune response
CC (By similarity). Plays a role during early embryonic development.
CC Involved in the formation of the anteroposterior axis with important
CC roles also in neural development. {ECO:0000250,
CC ECO:0000269|PubMed:20348034}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F1Q8W0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F1Q8W0-2; Sequence=VSP_044141, VSP_044142;
CC -!- DEVELOPMENTAL STAGE: Both maternally and zygotically expressed.
CC Expressed at all stages of early development. Expressed from 8-cell
CC stage to 48 hours post-fertilization (hpf). Expressed in the eyes at 48
CC hpf. {ECO:0000269|PubMed:20348034}.
CC -!- SIMILARITY: Belongs to the CACTIN family. {ECO:0000305}.
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DR EMBL; BX323861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR926137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC129326; AAI29327.1; -; mRNA.
DR RefSeq; XP_005168489.1; XM_005168432.3. [F1Q8W0-1]
DR AlphaFoldDB; F1Q8W0; -.
DR SMR; F1Q8W0; -.
DR STRING; 7955.ENSDARP00000078145; -.
DR PaxDb; F1Q8W0; -.
DR PRIDE; F1Q8W0; -.
DR Ensembl; ENSDART00000083710; ENSDARP00000078145; ENSDARG00000059866. [F1Q8W0-1]
DR GeneID; 100126813; -.
DR KEGG; dre:100126813; -.
DR CTD; 58509; -.
DR ZFIN; ZDB-GENE-060503-322; cactin.
DR eggNOG; KOG2370; Eukaryota.
DR GeneTree; ENSGT00950000183102; -.
DR HOGENOM; CLU_011759_0_0_1; -.
DR InParanoid; F1Q8W0; -.
DR OMA; HEPYMLL; -.
DR OrthoDB; 1252926at2759; -.
DR PhylomeDB; F1Q8W0; -.
DR TreeFam; TF300906; -.
DR PRO; PR:F1Q8W0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 2.
DR Bgee; ENSDARG00000059866; Expressed in early embryo and 23 other tissues.
DR ExpressionAtlas; F1Q8W0; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0008595; P:anterior/posterior axis specification, embryo; IMP:UniProtKB.
DR GO; GO:0001654; P:eye development; IMP:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0045824; P:negative regulation of innate immune response; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0003407; P:neural retina development; IMP:ZFIN.
DR GO; GO:0040019; P:positive regulation of embryonic development; IMP:UniProtKB.
DR InterPro; IPR019134; Cactin_C.
DR InterPro; IPR018816; Cactin_central.
DR Pfam; PF10312; Cactin_mid; 1.
DR Pfam; PF09732; CactinC_cactus; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Developmental protein; Immunity;
KW Innate immunity; Neurogenesis; Nucleus; Reference proteome.
FT CHAIN 1..835
FT /note="Cactin"
FT /id="PRO_0000419265"
FT REGION 1..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..164
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..557
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..411
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_044141"
FT VAR_SEQ 575..835
FT /note="EDEDRRSRRTGGEEAERSGRSSPEEEKKGEEEEGEKDEAPEAVLTEEDLIQQ
FT SQAEYDSGRYSPTLLQNSELPLDTHIIAEEEDLQRLLLARRQMQVTGDASESAEDLFVR
FT RAKEGMGGDEAQFSVEMPLTGKMYLWADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDN
FT PPPKIVQGYKFNIFYPDLIDKRSTPQYFLEPCPDNKDFGILRFHAGPPYEDIAFKIVNR
FT EWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR -> KEAEHFKTWAEQEDNFHLHQAKL
FT RSKIRIRDGRAKPIDLLAKYISAEDDDLSVEMHEPYTFLNGLTVTDMEETETALQMTTT
FT MIRRNRR (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_044142"
FT CONFLICT 561
FT /note="E -> D (in Ref. 2; AAI29327)"
FT /evidence="ECO:0000305"
FT CONFLICT 571
FT /note="A -> R (in Ref. 2; AAI29327)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 835 AA; 97996 MW; 33978D35CAA63976 CRC64;
MGSKKHRRSR SRSRSRERAR VVRHDRSPGD RHSRNRSPVK SSRRRARSDS GGSRSSGGSA
GPSRQRGRES GHSSDSDRQH RNTHGRNRDS SSDDDYHDKK KQALKKKHND EKDSRSRRRK
SRSSSGSSTN SSRERNRSKT SRSRERERRR RQSRSSSRER HRDQRRRRNS PERDRDRRRR
SQSRSSSSSS SDSDHGGKST QGGSSSKEEK KKQRDLMKAL ETPEEKRARR LAKKEAKERK
KREKMGWSEE YMGYTNADNP FGDNNLLGTF IWQKALEKKG IGHLSEKNLK DRNKHIQEEN
RRELQKVKQL RLEREREKAM REQELEMLQR EKEAEHFKTW AEQEDNFHLH QAKLRSKIRI
RDGRAKPIDL LAKYISAEDD DLSVEMHEPY TFLNGLTVTD MEDLLEDIKV YMELECGKNV
DFWRDMTTIT EDEISKLRKL EASGKGPGDR REGINTSVST DVQSVFKGKT YSQLQALYMN
IESKIQAGGS NLDIGYWESL LQQVRVYMAR ARLRERHQDV LRQKLYKLKQ EQGVESEPLF
PIIKEEPEKE QPISREAGSG EEEAGSSSQQ ADREEDEDRR SRRTGGEEAE RSGRSSPEEE
KKGEEEEGEK DEAPEAVLTE EDLIQQSQAE YDSGRYSPTL LQNSELPLDT HIIAEEEDLQ
RLLLARRQMQ VTGDASESAE DLFVRRAKEG MGGDEAQFSV EMPLTGKMYL WADKYRPRKP
RFFNRVHTGF EWNKYNQTHY DFDNPPPKIV QGYKFNIFYP DLIDKRSTPQ YFLEPCPDNK
DFGILRFHAG PPYEDIAFKI VNREWEYSHR HGFRCQFANG IFQLWFHFKR YRYRR
