ID   YBBO_ECOLI              Reviewed;         269 AA.
AC   P0AFP4; P77388; Q2MBT4;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Uncharacterized oxidoreductase YbbO;
DE            EC=1.-.-.-;
GN   Name=ybbO; OrderedLocusNames=b0493, JW0482;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; U82664; AAB40247.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC73595.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76272.1; -; Genomic_DNA.
DR   PIR; D64780; D64780.
DR   RefSeq; NP_415026.1; NC_000913.3.
DR   RefSeq; WP_000148959.1; NZ_STEB01000007.1.
DR   AlphaFoldDB; P0AFP4; -.
DR   SMR; P0AFP4; -.
DR   BioGRID; 4260670; 9.
DR   DIP; DIP-48139N; -.
DR   IntAct; P0AFP4; 16.
DR   STRING; 511145.b0493; -.
DR   jPOST; P0AFP4; -.
DR   PaxDb; P0AFP4; -.
DR   PRIDE; P0AFP4; -.
DR   EnsemblBacteria; AAC73595; AAC73595; b0493.
DR   EnsemblBacteria; BAE76272; BAE76272; BAE76272.
DR   GeneID; 60903777; -.
DR   GeneID; 945337; -.
DR   KEGG; ecj:JW0482; -.
DR   KEGG; eco:b0493; -.
DR   PATRIC; fig|511145.12.peg.514; -.
DR   EchoBASE; EB3050; -.
DR   eggNOG; COG0300; Bacteria.
DR   HOGENOM; CLU_010194_2_9_6; -.
DR   InParanoid; P0AFP4; -.
DR   OMA; QMDVTDR; -.
DR   PhylomeDB; P0AFP4; -.
DR   BioCyc; EcoCyc:G6269-MON; -.
DR   BioCyc; MetaCyc:G6269-MON; -.
DR   PRO; PR:P0AFP4; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IDA:EcoCyc.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0008202; P:steroid metabolic process; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..269
FT                   /note="Uncharacterized oxidoreductase YbbO"
FT                   /id="PRO_0000054822"
FT   ACT_SITE        159
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         15..41
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         146
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   269 AA;  29410 MW;  3EFC0E423AE89D87 CRC64;
     MTHKATEILT GKVMQKSVLI TGCSSGIGLE SALELKRQGF HVLAGCRKPD DVERMNSMGF
     TGVLIDLDSP ESVDRAADEV IALTDNCLYG IFNNAGFGMY GPLSTISRAQ MEQQFSANFF
     GAHQLTMRLL PAMLPHGEGR IVMTSSVMGL ISTPGRGAYA ASKYALEAWS DALRMELRHS
     GIKVSLIEPG PIRTRFTDNV NQTQSDKPVE NPGIAARFTL GPEAVVDKVR HAFISEKPKM
     RYPVTLVTWA VMVLKRLLPG RVMDKILQG