YBCB_SCHPO
ID YBCB_SCHPO Reviewed; 738 AA.
AC O13658;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Uncharacterized transcriptional regulatory protein C27B12.11c;
GN ORFNames=pi067, SPBC27B12.11c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=10620777;
RX DOI=10.1002/(sici)1097-0061(20000115)16:1<71::aid-yea505>3.0.co;2-5;
RA Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K.,
RA Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y.,
RA Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.;
RT "A 38 kb segment containing the cdc2 gene from the left arm of fission
RT yeast chromosome II: sequence analysis and characterization of the genomic
RT DNA and cDNAs encoded on the segment.";
RL Yeast 16:71-80(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-260 AND THR-261, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR EMBL; AB004539; BAA21449.1; -; Genomic_DNA.
DR EMBL; CU329671; CAA16906.1; -; Genomic_DNA.
DR PIR; T40035; T40035.
DR RefSeq; NP_595543.1; NM_001021454.2.
DR PDB; 6E33; X-ray; 1.71 A; A=279-339.
DR PDB; 6O19; X-ray; 1.60 A; A=279-336.
DR PDBsum; 6E33; -.
DR PDBsum; 6O19; -.
DR AlphaFoldDB; O13658; -.
DR SMR; O13658; -.
DR BioGRID; 277029; 14.
DR STRING; 4896.SPBC27B12.11c.1; -.
DR iPTMnet; O13658; -.
DR MaxQB; O13658; -.
DR PaxDb; O13658; -.
DR PRIDE; O13658; -.
DR EnsemblFungi; SPBC27B12.11c.1; SPBC27B12.11c.1:pep; SPBC27B12.11c.
DR GeneID; 2540501; -.
DR KEGG; spo:SPBC27B12.11c; -.
DR PomBase; SPBC27B12.11c; -.
DR VEuPathDB; FungiDB:SPBC27B12.11c; -.
DR eggNOG; ENOG502S5JI; Eukaryota.
DR HOGENOM; CLU_376051_0_0_1; -.
DR InParanoid; O13658; -.
DR OMA; SMLLFHD; -.
DR PRO; PR:O13658; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000785; C:chromatin; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; ISM:PomBase.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:PomBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:PomBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:PomBase.
DR GO; GO:0001162; F:RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; IPI:PomBase.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; ISM:PomBase.
DR GO; GO:0030643; P:cellular phosphate ion homeostasis; IMP:PomBase.
DR GO; GO:0016036; P:cellular response to phosphate starvation; IMP:PomBase.
DR GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:PomBase.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..738
FT /note="Uncharacterized transcriptional regulatory protein
FT C27B12.11c"
FT /id="PRO_0000310375"
FT DNA_BIND 292..318
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 260
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 261
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT HELIX 293..298
FT /evidence="ECO:0007829|PDB:6O19"
FT STRAND 304..307
FT /evidence="ECO:0007829|PDB:6O19"
FT HELIX 309..314
FT /evidence="ECO:0007829|PDB:6O19"
SQ SEQUENCE 738 AA; 81929 MW; CD2B301A5E64C760 CRC64;
MQKKVVQSAS KNEELDPHYK RSSVPFPYGL PDYDAEYQFI NHHMQQLLTR PVEGTHSASV
HPSTSSTSHI SSPSAFSVQN PNPNDAPFVG NIGLDASGFS SGGMSEYYPR SVSMQQSQDV
HFQNTEIPYY HRSPSSDSFS PGVVASVNPN SNNSPTFYSN PPALSNIPIP LNNSPYRPED
AYFQLQGAGV KADINPYNLS PYSQYGPEGT AYSNAQAHHQ DGAPLQRVCS APDPPKTSMP
PFGSAGSPSP NRSLNVSNNT TPPLSTVNKI IKKPKATTGK VKKRLPQAKR ACAKCQKDNK
KCDDARPCQR CIKAKTDCID LPRKKRPTGV RRGPYKKLSD TSNNTKSTTA SSGHSTQDSL
SSKMLDPSSD NQFAMSSRQM DENGMAQYPS SAIKQELNLQ PQILVSSASK NFQPNVTPPF
AVHHDHFNST SMDGVAVSNM DETGTSSAGS KPFNRKSRNR SFTNPVGMTE EHFLREYAQH
SVANPSLLIH QIHGLPSEQV HGLLSHTELG NAMHNQPTYN ESSIAAENVN NWMLETNDHE
NLSMQSHFEV PDLKMNHHDS SFFDRHIDQT AMPGQNQHGT VKNMETMHHF YPDVHNSEFP
AAPNPVKSQV PYYYQSQAAD DEEEDVPDHQ PSWRGRIHSF SIATDSSQHV VERPCIHSLR
GIHGQQDGGL EQHDGDHVNM LPDTHAEELA YTSMLLFHDI PTRDIRPDFN VHELVDHGTY
PNFHQNQADS FKNHPFRQ
