YBCC_SCHPO
ID YBCC_SCHPO Reviewed; 803 AA.
AC O13657; Q7LWD8;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Putative metal ion transporter C27B12.12c;
GN ORFNames=pi066, SPBC27B12.12c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=10620777;
RX DOI=10.1002/(sici)1097-0061(20000115)16:1<71::aid-yea505>3.0.co;2-5;
RA Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K.,
RA Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y.,
RA Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.;
RT "A 38 kb segment containing the cdc2 gene from the left arm of fission
RT yeast chromosome II: sequence analysis and characterization of the genomic
RT DNA and cDNAs encoded on the segment.";
RL Yeast 16:71-80(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318; SER-449 AND SER-452, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Membrane
CC {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000305}.
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DR EMBL; AB004538; BAA21447.1; -; Genomic_DNA.
DR EMBL; AB004539; BAA21448.1; -; Genomic_DNA.
DR EMBL; CU329671; CAA16907.1; -; Genomic_DNA.
DR PIR; T40036; T40036.
DR RefSeq; NP_595545.1; NM_001021456.2.
DR AlphaFoldDB; O13657; -.
DR SMR; O13657; -.
DR BioGRID; 276829; 5.
DR STRING; 284812.O13657; -.
DR TCDB; 1.A.35.2.3; the cora metal ion transporter (mit) family.
DR iPTMnet; O13657; -.
DR MaxQB; O13657; -.
DR PaxDb; O13657; -.
DR PRIDE; O13657; -.
DR EnsemblFungi; SPBC27B12.12c.1; SPBC27B12.12c.1:pep; SPBC27B12.12c.
DR GeneID; 2540298; -.
DR KEGG; spo:SPBC27B12.12c; -.
DR PomBase; SPBC27B12.12c; -.
DR VEuPathDB; FungiDB:SPBC27B12.12c; -.
DR eggNOG; ENOG502QPTQ; Eukaryota.
DR HOGENOM; CLU_007127_10_1_1; -.
DR InParanoid; O13657; -.
DR OMA; FPMQEES; -.
DR PhylomeDB; O13657; -.
DR PRO; PR:O13657; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005887; C:integral component of plasma membrane; NAS:PomBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:PomBase.
DR GO; GO:0010961; P:cellular magnesium ion homeostasis; IBA:GO_Central.
DR GO; GO:1903830; P:magnesium ion transmembrane transport; ISS:PomBase.
DR CDD; cd12829; Alr1p-like; 1.
DR InterPro; IPR044089; Alr1-like.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF143865; SSF143865; 1.
DR SUPFAM; SSF144083; SSF144083; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..803
FT /note="Putative metal ion transporter C27B12.12c"
FT /id="PRO_0000316218"
FT TRANSMEM 745..765
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 776..796
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..121
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 318
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 449
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 452
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 803 AA; 89397 MW; 5E1DB270D9D83572 CRC64;
MSFQQPSNGA QGGNNNALEK TSSNEATSSS STQVSSLSAS GISVSTPRVS PFEPERNMQV
QSSQHLEANV QSPVSSQTTY ATPSAYAVPQ ESEIELHESE MVPQKPKKKK RSRRNRKASR
KKIPATQSSS ADMDTLHVCP TCGSCSDSKK PQSNKKHRGR RVKHSPKSTL EVPDGIPDIK
ALSASMGSSS QHASRYNEGR GSFDTLGTHY HLSKSRKSSS SDSLYSVSSM SIKNDSNSDS
LSSSSSSDVS GSDENLPIDK TLYLSVEDPS FMVHPRRPSA TKSCSAAVDC PHTTIPKPPY
QSDTDLTELP TKSTAQFSDE TFTVQPRLKS THSSIADNED REVDSQVDEN TRVVEEDVCF
PMQEESHVNK GIDFDELDNF AEEELQKQRQ NTDHFRSRQY STCKPFEPHW NDLSPHDPND
PSSSLHSNNA EKAAEVPLRS SYYSGGRRSV TSMSDSPYRF SFFSSNQNET IHASVLSDLL
DDGATSFRSL FCPEKGVWWL DCLDPTDIEM RVLSKAFSIH PLTTEDIRVQ EAREKVELFG
SYYFVCFRSF EQDPELANYL EPLNMYIVVF REGLLTFHFS SATHPASVRR RARQLRDYVH
VSSDWLCYAL IDDITDAFVP LIRGIETETE AIEDSVLVGR SEDSSDMLRR IGECRKKTMG
MFRLLYGKAD VIKMLAKRCN EKWTIAPTGE IGLYLGDIQD HLVTMTSNLS QFEKILSRTH
SNYLAQLTSN SIEENSRTNG ALGKITLIGT LLVPMNLVTG LFGMNVPVPG RDTNNLAWFF
GILGVLLGSI AIGWIITMRY NAF
