ID   CATIP_DANRE             Reviewed;         356 AA.
AC   Q08CH6;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Ciliogenesis-associated TTC17-interacting protein;
GN   Name=catip; ORFNames=zgc:153063;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RX   PubMed=24475127; DOI=10.1371/journal.pone.0086476;
RA   Bontems F., Fish R.J., Borlat I., Lembo F., Chocu S., Chalmel F.,
RA   Borg J.P., Pineau C., Neerman-Arbez M., Bairoch A., Lane L.;
RT   "C2orf62 and TTC17 Are Involved in Actin Organization and Ciliogenesis in
RT   Zebrafish and Human.";
RL   PLoS ONE 9:E86476-E86476(2014).
CC   -!- FUNCTION: Plays a role in primary ciliogenesis by modulating actin
CC       polymerization. {ECO:0000269|PubMed:24475127}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in tissues rich in motile cilia.
CC       {ECO:0000269|PubMed:24475127}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in Kupffer's vesicle at 12 hours post
CC       fertilization (hpf). Expressed in brain, neural tube, pronephric ducts,
CC       olfactory placode and the eye at 28 hpf. Expressed in ciliated cells of
CC       the olfactory placode, ear, neuromasts and pronephric ducts at 48 hpf.
CC       Expressed in neuromasts, olfactory sensory neurons and in the ear at 96
CC       hpf (at protein level). {ECO:0000269|PubMed:24475127}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes curved
CC       body, a lack of defined brain structures or necrosis in the developing
CC       brain, and eye formation defects at 24 hpf. At 48 hpf, show a reduction
CC       in number of ciliated cells within the olfactory organ.
CC       {ECO:0000269|PubMed:24475127}.
CC   -!- SIMILARITY: Belongs to the CATIP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC124235; AAI24236.1; -; mRNA.
DR   RefSeq; NP_001070238.1; NM_001076770.1.
DR   AlphaFoldDB; Q08CH6; -.
DR   SMR; Q08CH6; -.
DR   STRING; 7955.ENSDARP00000086133; -.
DR   PaxDb; Q08CH6; -.
DR   Ensembl; ENSDART00000091700; ENSDARP00000086133; ENSDARG00000063009.
DR   GeneID; 767803; -.
DR   KEGG; dre:767803; -.
DR   CTD; 375307; -.
DR   ZFIN; ZDB-GENE-060929-1170; catip.
DR   eggNOG; ENOG502QPJE; Eukaryota.
DR   GeneTree; ENSGT00940000154101; -.
DR   HOGENOM; CLU_041155_0_0_1; -.
DR   InParanoid; Q08CH6; -.
DR   OMA; SPGCCMI; -.
DR   OrthoDB; 998907at2759; -.
DR   PhylomeDB; Q08CH6; -.
DR   TreeFam; TF328954; -.
DR   PRO; PR:Q08CH6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000063009; Expressed in testis and 14 other tissues.
DR   ExpressionAtlas; Q08CH6; baseline.
DR   GO; GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0030041; P:actin filament polymerization; IMP:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; IMP:ZFIN.
DR   GO; GO:0044782; P:cilium organization; IMP:UniProtKB.
DR   GO; GO:0061371; P:determination of heart left/right asymmetry; IMP:ZFIN.
PE   1: Evidence at protein level;
KW   Cell membrane; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Membrane; Nucleus; Reference proteome.
FT   CHAIN           1..356
FT                   /note="Ciliogenesis-associated TTC17-interacting protein"
FT                   /id="PRO_0000360989"
SQ   SEQUENCE   356 AA;  40632 MW;  A29265045B1C7B4B CRC64;
     MEESELTQNE TEELKASVSA VEFIHIAQRD LEQCLFADSL VTVSDSGREL GDFSVSVTKA
     SYNEELCYLL HANSHGTIDD VPCGTSIVAY ISRKLEILEE NHHEYVKLEK KTVDRKIHIV
     RQDDQLVVDR VISEREGVKT QTLKFPLSSL DGFVSEASNF LLLRIMARQK IVPENMTFLS
     LDADSGLSKS VYKALGWQKQ MVGEDLVDIF GIERTIYSAN LSSATWHCFF MPDGHLASRV
     QLGSPAVMKL LHLPFLLDGV IKTFFFLVEK DKIPVMEKKP LIWEEDMELY SKFLDRKEEL
     KADYSSYLRQ HPELKALLAD FLQFLLLRKP QDVFSFARDF FAPFASQSPP GKSQEF