YBDG_SHIFL
ID YBDG_SHIFL Reviewed; 415 AA.
AC P0AAT5; P39455; P77602;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Miniconductance mechanosensitive channel YbdG;
GN Name=ybdG; OrderedLocusNames=SF0483, S0492;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Mechanosensitive channel of miniconductance that confers
CC protection against mild hypoosmotic shock. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE005674; AAN42134.2; -; Genomic_DNA.
DR EMBL; AE014073; AAP16008.1; -; Genomic_DNA.
DR RefSeq; NP_706427.2; NC_004337.2.
DR RefSeq; WP_001153148.1; NZ_WPGW01000127.1.
DR AlphaFoldDB; P0AAT5; -.
DR STRING; 198214.SF0483; -.
DR EnsemblBacteria; AAN42134; AAN42134; SF0483.
DR EnsemblBacteria; AAP16008; AAP16008; S0492.
DR GeneID; 1023355; -.
DR GeneID; 58463690; -.
DR KEGG; sfl:SF0483; -.
DR KEGG; sfx:S0492; -.
DR PATRIC; fig|198214.7.peg.555; -.
DR HOGENOM; CLU_045354_1_0_6; -.
DR OMA; PTWRLMS; -.
DR OrthoDB; 1597438at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008381; F:mechanosensitive ion channel activity; IEA:InterPro.
DR GO; GO:0071470; P:cellular response to osmotic stress; IEA:InterPro.
DR Gene3D; 2.30.30.60; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR006685; MscS_channel.
DR InterPro; IPR011066; MscS_channel_C.
DR InterPro; IPR023408; MscS_dom_sf.
DR InterPro; IPR030192; YbdG.
DR PANTHER; PTHR30414; PTHR30414; 1.
DR Pfam; PF00924; MS_channel; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
DR SUPFAM; SSF82689; SSF82689; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion channel; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..415
FT /note="Miniconductance mechanosensitive channel YbdG"
FT /id="PRO_0000168668"
FT TOPO_DOM 1..24
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..104
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..173
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 195..415
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 415 AA; 46603 MW; C9A8A8A41CDC8F28 CRC64;
MQDLISQVED LAGIEIDHTT SMVMIFGIIF LTAVVVHIIL HWVVLRTFEK RAIASSRLWL
QIITQNKLFH RLAFTLQGII VNIQAVFWLQ KGTEAADILT TCAQLWIMMY ALLSVFSLLD
VILNLAQKFP AASQLPLKGI FQGIKLIGAI LVGILMISLL IGQSPAILIS GLGAMAAVLM
LVFKDPILGL VAGIQLSAND MLKLGDWLEM PKYGADGAVI DIGLTTVKVR NWDNTITTIP
TWSLVSDSFK NWSGMSASGG RRIKRSISID VTSIRFLDED EMQRLNKAHL LKPYLTSRHQ
EINEWNRQQG STESVLNLRR MTNIGTFRAY LNEYLRNHPR IRKDMTLMVR QLAPGDNGLP
LEIYAFTNTV VWLEYESIQA DIFDHIFAIV EEFGLRLHQS PTGNDIRSLA GAFKQ
