YBDO_ECOLI
ID YBDO_ECOLI Reviewed; 300 AA.
AC P77746;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Uncharacterized HTH-type transcriptional regulator YbdO;
GN Name=ybdO; OrderedLocusNames=b0603, JW0596;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP OPERON STRUCTURE, AND INDUCTION.
RC STRAIN=K12 / BW25113;
RX PubMed=19429622; DOI=10.1128/jb.00108-09;
RA Shimada T., Yamamoto K., Ishihama A.;
RT "Involvement of the leucine response transcription factor LeuO in
RT regulation of the genes for sulfa drug efflux.";
RL J. Bacteriol. 191:4562-4571(2009).
RN [6]
RP INDUCTION.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=26789284; DOI=10.1371/journal.pgen.1005796;
RA Higashi K., Tobe T., Kanai A., Uyar E., Ishikawa S., Suzuki Y.,
RA Ogasawara N., Kurokawa K., Oshima T.;
RT "H-NS facilitates sequence diversification of horizontally transferred DNAs
RT during their integration in host chromosomes.";
RL PLoS Genet. 12:E1005796-E1005796(2016).
CC -!- INDUCTION: Induced by LeuO, a monocistronic operon (PubMed:19429622).
CC Maximally induced in early stationary phase, repressed by H-NS via 2
CC binding sites in the upstream and coding region; H-NS may bind both
CC regions to form a bridge which then prevents transcription
CC (PubMed:26789284). {ECO:0000269|PubMed:19429622,
CC ECO:0000269|PubMed:26789284}.
CC -!- MISCELLANEOUS: The protein is quite variable across different genetic
CC subgroups, probably due to its binding and repression by H-NS
CC (PubMed:26789284). {ECO:0000305|PubMed:26789284}.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U82598; AAB40804.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73704.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA35233.1; -; Genomic_DNA.
DR PIR; A64794; A64794.
DR RefSeq; NP_415136.1; NC_000913.3.
DR RefSeq; WP_000002474.1; NZ_LN832404.1.
DR AlphaFoldDB; P77746; -.
DR SMR; P77746; -.
DR BioGRID; 4260901; 8.
DR BioGRID; 849601; 1.
DR IntAct; P77746; 5.
DR STRING; 511145.b0603; -.
DR PaxDb; P77746; -.
DR PRIDE; P77746; -.
DR DNASU; 945216; -.
DR EnsemblBacteria; AAC73704; AAC73704; b0603.
DR EnsemblBacteria; BAA35233; BAA35233; BAA35233.
DR GeneID; 945216; -.
DR KEGG; ecj:JW0596; -.
DR KEGG; eco:b0603; -.
DR PATRIC; fig|1411691.4.peg.1665; -.
DR EchoBASE; EB3305; -.
DR eggNOG; COG0583; Bacteria.
DR HOGENOM; CLU_039613_39_5_6; -.
DR OMA; QTINIMH; -.
DR PhylomeDB; P77746; -.
DR BioCyc; EcoCyc:G6332-MON; -.
DR PRO; PR:P77746; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..300
FT /note="Uncharacterized HTH-type transcriptional regulator
FT YbdO"
FT /id="PRO_0000105778"
FT DOMAIN 10..67
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 27..46
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ SEQUENCE 300 AA; 34397 MW; 1A5ECC6F28123D4F CRC64;
MANLYDLKKF DLNLLVIFEC IYQHLSISKA AESLYITPSA VSQSLQRLRA QFNDPLFIRS
GKGIAPTTTG LNLHHHLEKN LRGLEQTINI VNKSELKKNF IIYGPQLISC SNNSMLIRCL
RQDSSVEIEC HDILMSAENA EELLVHRKAD LVITQMPVIS RSVICMPLHT IRNTLICSNR
HPRITDNSTY EQIMAEEFTQ LISKSAGVDD IQMEIDERFM NRKISFRGSS LLTIINSIAV
TDLLGIVPYE LYNSYRDFLN LKEIKLEHPL PSIKLYISYN KSSLNNLVFS RFIDRLNESF
