YBDZ_ECOLI
ID YBDZ_ECOLI Reviewed; 72 AA.
AC P18393; Q2EEQ6; Q2MBL6;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Enterobactin biosynthesis protein YbdZ {ECO:0000305|PubMed:20845982};
GN Name=ybdZ {ECO:0000303|PubMed:20845982}; OrderedLocusNames=b4511, JW0577;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2974033; DOI=10.1016/s0021-9258(18)37361-7;
RA Pettis G.S., Brickman T.J., McIntosh M.A.;
RT "Transcriptional mapping and nucleotide sequence of the Escherichia coli
RT fepA-fes enterobactin region. Identification of a unique iron-regulated
RT bidirectional promoter.";
RL J. Biol. Chem. 263:18857-18863(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1826089; DOI=10.1021/bi00225a027;
RA Rusnak F., Sakaitani M., Drueckhammer D., Reichert J., Walsh C.T.;
RT "Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of
RT the entF gene, expression and purification of EntF, and analysis of
RT covalent phosphopantetheine.";
RL Biochemistry 30:2916-2927(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20845982; DOI=10.1021/bi1012854;
RA Felnagle E.A., Barkei J.J., Park H., Podevels A.M., McMahon M.D.,
RA Drott D.W., Thomas M.G.;
RT "MbtH-like proteins as integral components of bacterial nonribosomal
RT peptide synthetases.";
RL Biochemistry 49:8815-8817(2010).
CC -!- FUNCTION: Involved in the biosynthesis of the siderophore enterobactin
CC (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-
CC dihydroxybenzoyl)-serine. Plays a role in the catalytic function of
CC EntF. It is required for adenylation of amino acids in non-ribosomal
CC peptide biosynthesis. {ECO:0000269|PubMed:20845982}.
CC -!- DISRUPTION PHENOTYPE: Cells lacking this gene are not able to produce
CC enough enterobactin for efficient growth.
CC {ECO:0000269|PubMed:20845982}.
CC -!- SIMILARITY: Belongs to the MbtH-like family. {ECO:0000305}.
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DR EMBL; J04216; AAA23758.1; -; Genomic_DNA.
DR EMBL; M60177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U00096; ABD18641.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76340.1; -; Genomic_DNA.
DR PIR; B31958; Q3ECFS.
DR RefSeq; WP_000885798.1; NZ_SSZK01000032.1.
DR RefSeq; YP_588441.1; NC_000913.3.
DR PDB; 5JA1; X-ray; 3.00 A; B=1-72.
DR PDBsum; 5JA1; -.
DR AlphaFoldDB; P18393; -.
DR SMR; P18393; -.
DR IntAct; P18393; 1.
DR STRING; 511145.b4511; -.
DR PaxDb; P18393; -.
DR PRIDE; P18393; -.
DR EnsemblBacteria; ABD18641; ABD18641; b4511.
DR EnsemblBacteria; BAE76340; BAE76340; BAE76340.
DR GeneID; 1450243; -.
DR KEGG; ecj:JW0577; -.
DR KEGG; eco:b4511; -.
DR PATRIC; fig|1411691.4.peg.1685; -.
DR EchoBASE; EB4099; -.
DR eggNOG; COG3251; Bacteria.
DR HOGENOM; CLU_181321_1_0_6; -.
DR InParanoid; P18393; -.
DR OMA; QYSLWPG; -.
DR PhylomeDB; P18393; -.
DR BioCyc; EcoCyc:MON0-2659; -.
DR PRO; PR:P18393; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR GO; GO:0009239; P:enterobactin biosynthetic process; IDA:EcoCyc.
DR GO; GO:0043085; P:positive regulation of catalytic activity; IDA:EcoCyc.
DR GO; GO:0019290; P:siderophore biosynthetic process; IBA:GO_Central.
DR InterPro; IPR005153; MbtH-like_dom.
DR InterPro; IPR038020; MbtH-like_sf.
DR InterPro; IPR037407; MLP_fam.
DR PANTHER; PTHR38444; PTHR38444; 1.
DR Pfam; PF03621; MbtH; 1.
DR SMART; SM00923; MbtH; 1.
DR SUPFAM; SSF160582; SSF160582; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Enterobactin biosynthesis; Reference proteome.
FT CHAIN 1..72
FT /note="Enterobactin biosynthesis protein YbdZ"
FT /id="PRO_0000168673"
FT HELIX 6..8
FT /evidence="ECO:0007829|PDB:5JA1"
FT STRAND 14..18
FT /evidence="ECO:0007829|PDB:5JA1"
FT STRAND 24..28
FT /evidence="ECO:0007829|PDB:5JA1"
FT STRAND 38..44
FT /evidence="ECO:0007829|PDB:5JA1"
FT HELIX 46..56
FT /evidence="ECO:0007829|PDB:5JA1"
FT TURN 62..66
FT /evidence="ECO:0007829|PDB:5JA1"
SQ SEQUENCE 72 AA; 8271 MW; 164E0B87E00F1BB8 CRC64;
MAFSNPFDDP QGAFYILRNA QGQFSLWPQQ CVLPAGWDIV CQPQSQASCQ QWLEAHWRTL
TPTNFTQLQE AQ
