CATIP_MOUSE
ID CATIP_MOUSE Reviewed; 520 AA.
AC B9EKE5; Q3UUR2;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Ciliogenesis-associated TTC17-interacting protein;
GN Name=Catip; Synonyms=Gm216;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in primary ciliogenesis by modulating actin
CC polymerization. {ECO:0000250|UniProtKB:Q7Z7H3}.
CC -!- SUBUNIT: Interacts with TTC17. {ECO:0000250|UniProtKB:Q7Z7H3}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7Z7H3}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q7Z7H3}. Cell membrane
CC {ECO:0000250|UniProtKB:Q7Z7H3}. Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q7Z7H3}. Note=Colocalized with TTC17 at F-actin
CC rich zones and at dynamic plasma membrane protrusions.
CC {ECO:0000250|UniProtKB:Q7Z7H3}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=B9EKE5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=B9EKE5-2; Sequence=VSP_038747, VSP_038748;
CC -!- SIMILARITY: Belongs to the CATIP family. {ECO:0000305}.
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DR EMBL; GL456084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK138157; BAE23563.1; -; mRNA.
DR EMBL; BC150857; AAI50858.1; -; mRNA.
DR RefSeq; NP_001028517.1; NM_001033345.2.
DR RefSeq; XP_006496047.1; XM_006495984.1. [B9EKE5-1]
DR RefSeq; XP_006496049.1; XM_006495986.1. [B9EKE5-2]
DR RefSeq; XP_017176121.1; XM_017320632.1. [B9EKE5-1]
DR AlphaFoldDB; B9EKE5; -.
DR SMR; B9EKE5; -.
DR STRING; 10090.ENSMUSP00000095303; -.
DR PhosphoSitePlus; B9EKE5; -.
DR MaxQB; B9EKE5; -.
DR PaxDb; B9EKE5; -.
DR PRIDE; B9EKE5; -.
DR ProteomicsDB; 281223; -. [B9EKE5-1]
DR ProteomicsDB; 281224; -. [B9EKE5-2]
DR Antibodypedia; 34269; 295 antibodies from 13 providers.
DR Ensembl; ENSMUST00000097697; ENSMUSP00000095303; ENSMUSG00000073650. [B9EKE5-2]
DR Ensembl; ENSMUST00000191010; ENSMUSP00000141181; ENSMUSG00000073650. [B9EKE5-1]
DR GeneID; 241112; -.
DR UCSC; uc007blx.1; mouse. [B9EKE5-2]
DR UCSC; uc011wna.1; mouse. [B9EKE5-1]
DR CTD; 375307; -.
DR MGI; MGI:2685062; Catip.
DR VEuPathDB; HostDB:ENSMUSG00000073650; -.
DR eggNOG; ENOG502QPJE; Eukaryota.
DR GeneTree; ENSGT00940000154101; -.
DR HOGENOM; CLU_041155_0_0_1; -.
DR InParanoid; B9EKE5; -.
DR OMA; FHYSTDH; -.
DR OrthoDB; 998907at2759; -.
DR PhylomeDB; B9EKE5; -.
DR TreeFam; TF328954; -.
DR BioGRID-ORCS; 241112; 0 hits in 65 CRISPR screens.
DR PRO; PR:B9EKE5; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; B9EKE5; protein.
DR Bgee; ENSMUSG00000073650; Expressed in spermatid and 48 other tissues.
DR ExpressionAtlas; B9EKE5; baseline and differential.
DR GO; GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0030041; P:actin filament polymerization; ISS:UniProtKB.
DR GO; GO:0044782; P:cilium organization; ISS:UniProtKB.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Cilium biogenesis/degradation;
KW Cytoplasm; Cytoskeleton; Membrane; Nucleus; Reference proteome.
FT CHAIN 1..520
FT /note="Ciliogenesis-associated TTC17-interacting protein"
FT /id="PRO_0000391708"
FT REGION 352..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..409
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..483
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..19
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_038747"
FT VAR_SEQ 20..27
FT /note="ETASLHHP -> MTRRSDGA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_038748"
SQ SEQUENCE 520 AA; 59301 MW; 56016743F6D63E97 CRC64;
MGDVTRGEWV VWGLEAGPGE TASLHHPGLE DMLLFFPETL AILSDTGEPQ GELTIEVQRG
KYKDDIGILT HCLLVHASSR GFLDKSLCGS SLLGYLNNNL ELMEQHSQEF IKFPVLPMER
KMSVLKQDGQ FVVTRSVKEG EETKTGVSVF PYKTFKGFVS SAANVVLLRV MAWQQSVPSG
ARFLALDSEG KLCHCTYKSL GFQTIQVGNQ QAKMFIVEQT IHSEEGIPFS CQYYLLPDGH
LAKRVQVGSP GCCIITKMPL IREEDVIESP PTFDKKPLVW GEDLELYSKF LDRKEQLRLS
HASYLRHHPE AQALVSDFLL FLLLRRPEDV VTFAAEHFRP FAALRSPIPA LRSSHQPSPF
RTLENEEEEE AKEEEEKEEE EEEEEEIAGE IEGEEEEEEI EEGDDYLYMD EDEDIEDYTY
YENYYYNYDE EVDSYDDVNN YDDDDIANVD DNDDIDNYDD DNDDDDDDDD NDDEDDVDDN
DDDDVDKVRA KVDNLSVDND DNDVVNSDNV DVDNDNNNQG
