CATIP_RAT
ID CATIP_RAT Reviewed; 489 AA.
AC M0RAU5;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2013, sequence version 1.
DT 25-MAY-2022, entry version 34.
DE RecName: Full=Ciliogenesis-associated TTC17-interacting protein;
GN Name=Catip;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=24475127; DOI=10.1371/journal.pone.0086476;
RA Bontems F., Fish R.J., Borlat I., Lembo F., Chocu S., Chalmel F.,
RA Borg J.P., Pineau C., Neerman-Arbez M., Bairoch A., Lane L.;
RT "C2orf62 and TTC17 Are Involved in Actin Organization and Ciliogenesis in
RT Zebrafish and Human.";
RL PLoS ONE 9:E86476-E86476(2014).
CC -!- FUNCTION: Plays a role in primary ciliogenesis by modulating actin
CC polymerization. {ECO:0000250|UniProtKB:Q7Z7H3}.
CC -!- SUBUNIT: Interacts with TTC17. {ECO:0000250|UniProtKB:Q7Z7H3}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24475127}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q7Z7H3}. Cell membrane
CC {ECO:0000250|UniProtKB:Q7Z7H3}. Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q7Z7H3}. Note=Colocalized with TTC17 at F-actin
CC rich zones and at dynamic plasma membrane protrusions.
CC {ECO:0000250|UniProtKB:Q7Z7H3}.
CC -!- TISSUE SPECIFICITY: Expressed in testis and ovary. Strongly expressed
CC in pachytene spermatocytes and round spermatids compared to
CC spermatogonia and somatic cells. Expressed in Leydig cells (at protein
CC level). {ECO:0000269|PubMed:24475127}.
CC -!- SIMILARITY: Belongs to the CATIP family. {ECO:0000305}.
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DR EMBL; AABR06061095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M0RAU5; -.
DR STRING; 10116.ENSRNOP00000066656; -.
DR PaxDb; M0RAU5; -.
DR RGD; 1596071; Catip.
DR eggNOG; ENOG502QPJE; Eukaryota.
DR InParanoid; M0RAU5; -.
DR PRO; PR:M0RAU5; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0030041; P:actin filament polymerization; ISS:UniProtKB.
DR GO; GO:0044782; P:cilium organization; ISS:UniProtKB.
PE 1: Evidence at protein level;
KW Cell membrane; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW Membrane; Nucleus; Reference proteome.
FT CHAIN 1..489
FT /note="Ciliogenesis-associated TTC17-interacting protein"
FT /id="PRO_0000426007"
FT REGION 350..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..412
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 489 AA; 55767 MW; D841DDCA86CB24B8 CRC64;
MGDKAKGEGM VWGLEAGPGE ASLCHTGLED MLLFFPETLA ILSDTGEPQG ELTIEVQKGK
YKDDLGILTH CLLVHASSRG FLDKSVCGSS LLGYLNEHLE LMEQHSQEFI KFPIIPMERK
MSVLKQDDQL VVSRSVKEGE ETKTGVSVFP CKSLKGFVSS AANVVLLRVM AWRQSVPSGA
RFLALDSEGK LCYCTYKSLG FQTIQVGNQQ AEMFIVEQTI HSEDGIPFSC QFYLLSDGHL
AKRVQVGSPG CCIITKMPLI REEDVIEPPP TFDRKPLVWE EDLELYSKFL DRKEQLRLSH
TRYLRQHPEA QALVSDFLLF LLLRRPEDVV TFAAEHFGPF AALRSPIPAL RSSHQPSPFR
SLEEEEEGEE EEEEEEEEEE GEEEGEGKEE VEEVEIEGDD DYLYVDEEEE VEDDIYYDSY
YYKYEDENIY EDENIYYDNY DVDNDNDDID NYDNDDDDDD DVDDDDDVKV DDDNVDVDND
NVDVDNDNI
