ID   CATL1_FASHE             Reviewed;          20 AA.
AC   Q09093;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Cathepsin L1;
DE            EC=3.4.22.15;
DE   Flags: Fragment;
OS   Fasciola hepatica (Liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Fasciolidae;
OC   Fasciola.
OX   NCBI_TaxID=6192;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=8114809; DOI=10.1016/0166-6851(93)90171-s;
RA   Smith A.M., Dowd A.J., McGonigle S., Keegan P.S., Brennan G., Trudgett A.,
RA   Dalton J.P.;
RT   "Purification of a cathepsin L-like proteinase secreted by adult Fasciola
RT   hepatica.";
RL   Mol. Biochem. Parasitol. 62:1-8(1993).
CC   -!- FUNCTION: Thiol protease that assists the parasite in burrowing through
CC       the gut wall and liver of its mammalian host.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Specificity close to that of papain. As compared to cathepsin
CC         B, cathepsin L exhibits higher activity toward protein substrates,
CC         but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-
CC         dipeptidase activity.; EC=3.4.22.15;
CC   -!- SUBUNIT: Dimer of a heavy and a light chain linked by disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Lysosome.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU10088, ECO:0000255|PROSITE-ProRule:PRU10089,
CC       ECO:0000255|PROSITE-ProRule:PRU10090}.
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DR   PIR; S68785; S68785.
DR   AlphaFoldDB; Q09093; -.
DR   DrugBank; DB12245; Triclabendazole.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydrolase; Lysosome; Protease;
KW   Thiol protease.
FT   CHAIN           1..>20
FT                   /note="Cathepsin L1"
FT                   /id="PRO_0000050538"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         20
SQ   SEQUENCE   20 AA;  2174 MW;  97CDEDB33055BCAE CRC64;
     AVPDKIDPRE SGYVTGVKDQ