ID   CATL3_FASHE             Reviewed;          19 AA.
AC   P80532;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Putative cathepsin L3;
DE            EC=3.4.22.15;
DE   AltName: Full=Newly excysted juvenile protein 8;
DE   Flags: Fragment;
OS   Fasciola hepatica (Liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Fasciolidae;
OC   Fasciola.
OX   NCBI_TaxID=6192;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7639732; DOI=10.1006/bbrc.1995.2112;
RA   Tkalcevic J., Ashman K., Meeusen E.;
RT   "Fasciola hepatica: rapid identification of newly excysted juvenile
RT   proteins.";
RL   Biochem. Biophys. Res. Commun. 213:169-174(1995).
CC   -!- FUNCTION: Thiol protease.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Specificity close to that of papain. As compared to cathepsin
CC         B, cathepsin L exhibits higher activity toward protein substrates,
CC         but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-
CC         dipeptidase activity.; EC=3.4.22.15;
CC   -!- SUBUNIT: Dimer of a heavy and a light chain linked by disulfide bonds.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at the newly excysted juvenile stage.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU10088, ECO:0000255|PROSITE-ProRule:PRU10089,
CC       ECO:0000255|PROSITE-ProRule:PRU10090}.
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DR   AlphaFoldDB; P80532; -.
DR   BRENDA; 3.4.22.B62; 2230.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydrolase; Lysosome; Protease;
KW   Thiol protease.
FT   CHAIN           1..>19
FT                   /note="Putative cathepsin L3"
FT                   /id="PRO_0000050540"
FT   NON_TER         19
SQ   SEQUENCE   19 AA;  2242 MW;  53FFB5835EBCB0D7 CRC64;
     DVPASIDWRE YGYVTEVKD