YBEY_MOUSE
ID YBEY_MOUSE Reviewed; 164 AA.
AC Q8CAV0; Q3UW80; Q6PG17;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Endoribonuclease YbeY {ECO:0000305};
DE EC=3.1.-.- {ECO:0000305};
GN Name=Ybey;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cecum, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 143-150, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Lubec G., Kang S.U.;
RL Submitted (APR-2007) to UniProtKB.
CC -!- FUNCTION: Single strand-specific metallo-endoribonuclease involved in
CC rRNA maturation. {ECO:0000250|UniProtKB:P58557}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000250|UniProtKB:P71335};
CC Note=Binds 1 zinc ion. {ECO:0000250|UniProtKB:P71335};
CC -!- SIMILARITY: Belongs to the endoribonuclease YbeY family. {ECO:0000305}.
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DR EMBL; AK037727; BAC29859.1; -; mRNA.
DR EMBL; AK136543; BAE23037.1; -; mRNA.
DR EMBL; BC057308; AAH57308.1; -; mRNA.
DR CCDS; CCDS23946.1; -.
DR RefSeq; NP_766138.3; NM_172550.4.
DR AlphaFoldDB; Q8CAV0; -.
DR SMR; Q8CAV0; -.
DR IntAct; Q8CAV0; 1.
DR STRING; 10090.ENSMUSP00000045647; -.
DR iPTMnet; Q8CAV0; -.
DR PhosphoSitePlus; Q8CAV0; -.
DR EPD; Q8CAV0; -.
DR MaxQB; Q8CAV0; -.
DR PaxDb; Q8CAV0; -.
DR PRIDE; Q8CAV0; -.
DR ProteomicsDB; 299806; -.
DR Antibodypedia; 10671; 37 antibodies from 10 providers.
DR DNASU; 216119; -.
DR Ensembl; ENSMUST00000049185; ENSMUSP00000045647; ENSMUSG00000033126.
DR GeneID; 216119; -.
DR KEGG; mmu:216119; -.
DR UCSC; uc007fuo.1; mouse.
DR CTD; 54059; -.
DR MGI; MGI:2656825; Ybey.
DR VEuPathDB; HostDB:ENSMUSG00000033126; -.
DR eggNOG; ENOG502R6QZ; Eukaryota.
DR GeneTree; ENSGT00950000183170; -.
DR HOGENOM; CLU_106710_4_0_1; -.
DR InParanoid; Q8CAV0; -.
DR OMA; IICVDNR; -.
DR OrthoDB; 1269091at2759; -.
DR PhylomeDB; Q8CAV0; -.
DR TreeFam; TF332551; -.
DR BioGRID-ORCS; 216119; 18 hits in 70 CRISPR screens.
DR ChiTaRS; Ybey; mouse.
DR PRO; PR:Q8CAV0; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8CAV0; protein.
DR Bgee; ENSMUSG00000033126; Expressed in ectoplacental cone and 74 other tissues.
DR Genevisible; Q8CAV0; MM.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0004521; F:endoribonuclease activity; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR Gene3D; 3.40.390.30; -; 1.
DR HAMAP; MF_00009; Endoribonucl_YbeY; 1.
DR InterPro; IPR023091; MetalPrtase_cat_dom_sf_prd.
DR InterPro; IPR002036; YbeY.
DR InterPro; IPR020549; YbeY_CS.
DR Pfam; PF02130; YbeY; 1.
DR TIGRFAMs; TIGR00043; TIGR00043; 1.
DR PROSITE; PS01306; UPF0054; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Endonuclease; Hydrolase; Metal-binding;
KW Nuclease; Reference proteome; Zinc.
FT CHAIN 1..164
FT /note="Endoribonuclease YbeY"
FT /id="PRO_0000102579"
FT BINDING 118
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250|UniProtKB:P71335"
FT BINDING 122
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250|UniProtKB:P71335"
FT BINDING 128
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250|UniProtKB:P71335"
FT CONFLICT 147
FT /note="E -> D (in Ref. 2; AAH57308)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 164 AA; 18989 MW; E64433FF6FC4D3A9 CRC64;
MSLVIKNLQR VVPIRRVPLR RKMDLVRSIL GVKKFDLGII CVDNKTIQNI NRIYRNKNVP
TDVLSFSFHE NLKAGEFPQP HSPDDYNLGD IFLGVEYILQ HCRESEDYCD VLTVTATHGL
CHLLGFTHSS KAEWQKMYNQ EKLVLEELSR YTGARLQPLS RGLY
