ID   CATQ_RAT                Reviewed;         343 AA.
AC   Q9QZE3;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Cathepsin Q;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=Ctsq; Synonyms=Catq;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Placenta;
RX   PubMed=10673370; DOI=10.1006/bbrc.1999.2051;
RA   Sol-Church K., Frenck J., Mason R.W.;
RT   "Cathepsin Q, a novel lysosomal cysteine protease highly expressed in
RT   placenta.";
RL   Biochem. Biophys. Res. Commun. 267:791-795(2000).
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in placenta.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU10089, ECO:0000255|PROSITE-ProRule:PRU10090}.
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DR   EMBL; AF187323; AAF01247.1; -; mRNA.
DR   PIR; JC7183; JC7183.
DR   RefSeq; NP_640355.1; NM_139262.1.
DR   AlphaFoldDB; Q9QZE3; -.
DR   SMR; Q9QZE3; -.
DR   STRING; 10116.ENSRNOP00000024208; -.
DR   MEROPS; C01.039; -.
DR   GlyGen; Q9QZE3; 2 sites.
DR   PaxDb; Q9QZE3; -.
DR   Ensembl; ENSRNOT00000073585; ENSRNOP00000066947; ENSRNOG00000048693.
DR   GeneID; 246147; -.
DR   KEGG; rno:246147; -.
DR   UCSC; RGD:631421; rat.
DR   CTD; 104002; -.
DR   RGD; 631421; Ctsq.
DR   VEuPathDB; HostDB:ENSRNOG00000017946; -.
DR   eggNOG; KOG1543; Eukaryota.
DR   GeneTree; ENSGT00940000153321; -.
DR   HOGENOM; CLU_012184_1_2_1; -.
DR   InParanoid; Q9QZE3; -.
DR   OMA; LYNVPNC; -.
DR   OrthoDB; 1275401at2759; -.
DR   PhylomeDB; Q9QZE3; -.
DR   TreeFam; TF313739; -.
DR   PRO; PR:Q9QZE3; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   Genevisible; Q9QZE3; RN.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR   CDD; cd02248; Peptidase_C1A; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR025661; Pept_asp_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR039417; Peptidase_C1A_papain-like.
DR   InterPro; IPR013201; Prot_inhib_I29.
DR   Pfam; PF08246; Inhibitor_I29; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00848; Inhibitor_I29; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Protease;
KW   Reference proteome; Signal; Thiol protease; Zymogen.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..124
FT                   /note="Activation peptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000026234"
FT   CHAIN           125..343
FT                   /note="Cathepsin Q"
FT                   /id="PRO_0000026235"
FT   ACT_SITE        149
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        286
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        310
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        228
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        298
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        146..189
FT                   /evidence="ECO:0000250"
FT   DISULFID        180..222
FT                   /evidence="ECO:0000250"
FT   DISULFID        280..332
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   343 AA;  39052 MW;  617A7156F33645D4 CRC64;
     MTPAVFLVIL CLGVVPGASA LDLSLDVQWQ EWKIKYEKLY SPEEEVLKRV VWEENVKKIE
     LHNRENSLGK NTYTMEINDF ADMTDEEFKD MIIGFQLPVH NTEKRLWKRA LGSFFPNSWN
     WRDALPKFVD WRNEGYVTRV RKQGGCSSCW AFPVTGAIEG QMFKKTGKLI PLSVQNLIDC
     SKPQGNRGCL WGNTYNAFQY VLHNGGLEAE ATYPYERKEG VCRYNPKNSS AKITGFVVLP
     ESEDVLMDAV ATKGPIATGV HVISSSFRFY QKGVYHEPKC SSYVNHAVLV VGYGFEGNET
     DGNNYWLIKN SWGKRWGLRG YMKIAKDRNN HCAIASLAQY PTV