ID   CATR5_PARTE             Reviewed;         174 AA.
AC   Q3SEK0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Caltractin ICL1e;
DE   AltName: Full=Centrin-5;
GN   Name=Icl1e; ORFNames=GSPATT00007681001;
OS   Paramecium tetraurelia.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX   NCBI_TaxID=5888;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Stock d4-2;
RA   Klotz C.;
RT   "Paramecium tetraurelia centrin-related protein genes.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Stock d4-2;
RX   PubMed=17086204; DOI=10.1038/nature05230;
RA   Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA   Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA   Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA   Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA   Le Mouel A., Lepere G., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA   Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA   Weissenbach J., Scarpelli C., Schaechter V., Sperling L., Meyer E.,
RA   Cohen J., Wincker P.;
RT   "Global trends of whole-genome duplications revealed by the ciliate
RT   Paramecium tetraurelia.";
RL   Nature 444:171-178(2006).
CC   -!- FUNCTION: Plays a fundamental role in microtubule organizing center
CC       structure and function. Component of the infraciliary lattice (ICL) and
CC       the ciliary basal bodies (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Note=ICL,
CC       innermost fibrous network of the cortical cytoskeleton. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the centrin family. {ECO:0000305}.
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DR   EMBL; CR932084; CAI38924.1; -; Genomic_DNA.
DR   EMBL; CT868085; CAK70546.1; -; Genomic_DNA.
DR   RefSeq; XP_001437943.1; XM_001437906.1.
DR   AlphaFoldDB; Q3SEK0; -.
DR   SMR; Q3SEK0; -.
DR   STRING; 5888.CAK70546; -.
DR   EnsemblProtists; CAK70546; CAK70546; GSPATT00007681001.
DR   GeneID; 5023728; -.
DR   KEGG; ptm:GSPATT00007681001; -.
DR   eggNOG; KOG0028; Eukaryota.
DR   HOGENOM; CLU_061288_18_2_1; -.
DR   InParanoid; Q3SEK0; -.
DR   OMA; HEMIERT; -.
DR   Proteomes; UP000000600; Partially assembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00051; EFh; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   Pfam; PF13405; EF-hand_6; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 3.
PE   3: Inferred from homology;
KW   Calcium; Cytoplasm; Cytoskeleton; Metal-binding; Reference proteome;
KW   Repeat.
FT   CHAIN           1..174
FT                   /note="Caltractin ICL1e"
FT                   /id="PRO_0000307826"
FT   DOMAIN          33..68
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          88..103
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          105..140
FT                   /note="EF-hand 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          141..174
FT                   /note="EF-hand 4"
FT                   /evidence="ECO:0000305"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   174 AA;  19751 MW;  DACD77E096B484D4 CRC64;
     MSKKQQAPVA QKPVGKQQQV NRKPQDRPGL TEDEIEEIKE AFNLFDTEGT GRVDPRELKA
     AMQSLGFDQK NPTIFNMIAE LENEGTDIDF DQFLDAITSK LGNRESRDGI NKIFDLFDDD
     GSNSINLNNL KRVSKELGET MTAEELAEML ERAASNGRDI SREDFYNIMV KRTF