ID   CATR_PSEPU              Reviewed;         289 AA.
AC   P20667;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=HTH-type transcriptional regulator CatR;
DE   AltName: Full=CatBC operon transcriptional activator;
GN   Name=catR;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1688844; DOI=10.1128/jb.172.2.922-931.1990;
RA   Rothmel R.K., Aldrich T.L., Houghton J.E., Coco W.M., Ornston L.N.,
RA   Chakrabarty A.M.;
RT   "Nucleotide sequencing and characterization of Pseudomonas putida catR: a
RT   positive regulator of the catBC operon is a member of the LysR family.";
RL   J. Bacteriol. 172:922-931(1990).
CC   -!- FUNCTION: Positive regulator of the catBC operon that degrades catechol
CC       to acetyl-CoA. CatR binds in trans to the catR-catBC promoter-control
CC       region in the presence or absence of inducer but only activates the
CC       catBC operon in the presence of the inducer, cis-cis-muconate.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; M33817; AAA25768.1; -; Genomic_DNA.
DR   PIR; A35118; A35118.
DR   AlphaFoldDB; P20667; -.
DR   SMR; P20667; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Aromatic hydrocarbons catabolism; Cytoplasm; DNA-binding;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..289
FT                   /note="HTH-type transcriptional regulator CatR"
FT                   /id="PRO_0000105601"
FT   DOMAIN          1..57
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   289 AA;  32194 MW;  751C53101289D55B CRC64;
     MELRHLRYFK VLAETLNFTR AAELLHIAQP PLSRQISQLE DQLGTLLVVR ERPLRLTEAG
     RFFYEQSCTV LQLQNISDNT RRIGQGQRQW LGIGFAPSTL YKVLPELIRE LRQDSELELG
     LNEMTTLQQV EALKSGRIDI AFGRIRIDDP AIHQQVLCED PLVAVLPKDH PLASSPLTLA
     QLAGEAFILY PANPRPSYAD HVLALFAHHG MSIHVSQWAN ELQTAIGLVA VGVGVTLVPA
     SVQQQHRTDI EYVSLLDSGA VSPIILSRRK GDVSPIVQRC LTLIAQQAE