YBHF_ECOLI
ID YBHF_ECOLI Reviewed; 578 AA.
AC P0A9U1; P75776; Q9R7S3; Q9R7S4;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Probable multidrug ABC transporter ATP-binding protein YbhF {ECO:0000305};
GN Name=ybhF; OrderedLocusNames=b0794, JW5104;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=27112147; DOI=10.1099/mic.0.000292;
RA Yamanaka Y., Shimada T., Yamamoto K., Ishihama A.;
RT "Transcription factor CecR (YbiH) regulates a set of genes affecting the
RT sensitivity of Escherichia coli against cefoperazone and chloramphenicol.";
RL Microbiology 162:1253-1264(2016).
CC -!- FUNCTION: Part of the ABC transporter complex YbhFSR that could be
CC involved in efflux of cefoperazone. Probably responsible for energy
CC coupling to the transport system. {ECO:0000305|PubMed:27112147}.
CC -!- SUBUNIT: The complex is probably composed of two ATP-binding proteins
CC (YbhF) and two transmembrane proteins (YbhR and YbhS). {ECO:0000305}.
CC -!- INTERACTION:
CC P0A9U1; P0AFG8: aceE; NbExp=3; IntAct=EBI-547696, EBI-542683;
CC P0A9U1; P60566: fixA; NbExp=3; IntAct=EBI-547696, EBI-1113126;
CC -!- INDUCTION: Repressed by the transcriptional regulator CecR.
CC {ECO:0000269|PubMed:27112147}.
CC -!- DISRUPTION PHENOTYPE: Mutant shows increased sensitivity to
CC cefoperazone, a third-generation cephalosporin.
CC {ECO:0000269|PubMed:27112147}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; U00096; AAC73881.2; -; Genomic_DNA.
DR EMBL; AP009048; BAA35454.2; -; Genomic_DNA.
DR PIR; B64816; B64816.
DR RefSeq; NP_415315.4; NC_000913.3.
DR RefSeq; WP_000996107.1; NZ_LN832404.1.
DR AlphaFoldDB; P0A9U1; -.
DR SMR; P0A9U1; -.
DR BioGRID; 4261836; 19.
DR BioGRID; 849787; 1.
DR ComplexPortal; CPX-4443; Sodium/lithium ABC transporter complex.
DR DIP; DIP-48149N; -.
DR IntAct; P0A9U1; 7.
DR STRING; 511145.b0794; -.
DR TCDB; 3.A.1.105.15; the atp-binding cassette (abc) superfamily.
DR jPOST; P0A9U1; -.
DR PaxDb; P0A9U1; -.
DR PRIDE; P0A9U1; -.
DR EnsemblBacteria; AAC73881; AAC73881; b0794.
DR EnsemblBacteria; BAA35454; BAA35454; BAA35454.
DR GeneID; 58389453; -.
DR GeneID; 945413; -.
DR KEGG; ecj:JW5104; -.
DR KEGG; eco:b0794; -.
DR PATRIC; fig|1411691.4.peg.1484; -.
DR EchoBASE; EB3098; -.
DR eggNOG; COG1131; Bacteria.
DR HOGENOM; CLU_000604_83_0_6; -.
DR InParanoid; P0A9U1; -.
DR OMA; YCDRIVI; -.
DR PhylomeDB; P0A9U1; -.
DR BioCyc; EcoCyc:YBHF-MON; -.
DR BioCyc; MetaCyc:YBHF-MON; -.
DR PRO; PR:P0A9U1; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IMP:EcoCyc.
DR GO; GO:0090452; P:lithium ion transmembrane transport; IC:ComplexPortal.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IC:ComplexPortal.
DR GO; GO:0015904; P:tetracycline transmembrane transport; IC:ComplexPortal.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IMP:EcoCyc.
DR GO; GO:0006855; P:xenobiotic transmembrane transport; IC:ComplexPortal.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 1: Evidence at protein level;
KW ATP-binding; Nucleotide-binding; Reference proteome; Repeat; Transport.
FT CHAIN 1..578
FT /note="Probable multidrug ABC transporter ATP-binding
FT protein YbhF"
FT /id="PRO_0000093156"
FT DOMAIN 6..237
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 330..559
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 40..47
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 362..369
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 578 AA; 63132 MW; DB3B3FA213490F3C CRC64;
MNDAVITLNG LEKRFPGMDK PAVAPLDCTI HAGYVTGLVG PDGAGKTTLM RMLAGLLKPD
SGSATVIGFD PIKNDGALHA VLGYMPQKFG LYEDLTVMEN LNLYADLRSV TGEARKQTFA
RLLEFTSLGP FTGRLAGKLS GGMKQKLGLA CTLVGEPKVL LLDEPGVGVD PISRRELWQM
VHELAGEGML ILWSTSYLDE AEQCRDVLLM NEGELLYQGE PKALTQTMAG RSFLMTSPHE
GNRKLLQRAL KLPQVSDGMI QGKSVRLILK KEATPDDIRH ADGMPEININ ETTPRFEDAF
IDLLGGAGTS ESPLGAILHT VEGTPGETVI EAKELTKKFG DFAATDHVNF AVKRGEIFGL
LGPNGAGKST TFKMMCGLLV PTSGQALVLG MDLKESSGKA RQHLGYMAQK FSLYGNLTVE
QNLRFFSGVY GLRGRAQNEK ISRMSEAFGL KSIASHATDE LPLGFKQRLA LACSLMHEPD
ILFLDEPTSG VDPLTRREFW LHINSMVEKG VTVMVTTHFM DEAEYCDRIG LVYRGKLIAS
GTPDDLKAQS ANDEQPDPTM EQAFIQLIHD WDKEHSNE
