ID   YBHF_SHIFL              Reviewed;         578 AA.
AC   P0A9U2; P75776; Q9R7S3; Q9R7S4;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Probable multidrug ABC transporter ATP-binding protein YbhF {ECO:0000250|UniProtKB:P0A9U1};
GN   Name=ybhF; OrderedLocusNames=SF0744, S0785;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Part of the ABC transporter complex YbhFSR that could be
CC       involved in efflux of cefoperazone. Probably responsible for energy
CC       coupling to the transport system. {ECO:0000250|UniProtKB:P0A9U1}.
CC   -!- SUBUNIT: The complex is probably composed of two ATP-binding proteins
CC       (YbhF) and two transmembrane proteins (YbhR and YbhS).
CC       {ECO:0000250|UniProtKB:P0A9U1}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN42379.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAP16256.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005674; AAN42379.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014073; AAP16256.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_706672.1; NC_004337.2.
DR   RefSeq; WP_000996107.1; NZ_WPGW01000030.1.
DR   AlphaFoldDB; P0A9U2; -.
DR   SMR; P0A9U2; -.
DR   STRING; 198214.SF0744; -.
DR   EnsemblBacteria; AAN42379; AAN42379; SF0744.
DR   EnsemblBacteria; AAP16256; AAP16256; S0785.
DR   GeneID; 1023711; -.
DR   GeneID; 58389453; -.
DR   KEGG; sfl:SF0744; -.
DR   KEGG; sfx:S0785; -.
DR   PATRIC; fig|198214.7.peg.865; -.
DR   HOGENOM; CLU_000604_83_0_6; -.
DR   OrthoDB; 870493at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Reference proteome; Repeat; Transport.
FT   CHAIN           1..578
FT                   /note="Probable multidrug ABC transporter ATP-binding
FT                   protein YbhF"
FT                   /id="PRO_0000093157"
FT   DOMAIN          6..237
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          330..559
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         40..47
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         362..369
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   CONFLICT        44
FT                   /note="A -> E (in Ref. 2; AAP16256)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   578 AA;  63132 MW;  DB3B3FA213490F3C CRC64;
     MNDAVITLNG LEKRFPGMDK PAVAPLDCTI HAGYVTGLVG PDGAGKTTLM RMLAGLLKPD
     SGSATVIGFD PIKNDGALHA VLGYMPQKFG LYEDLTVMEN LNLYADLRSV TGEARKQTFA
     RLLEFTSLGP FTGRLAGKLS GGMKQKLGLA CTLVGEPKVL LLDEPGVGVD PISRRELWQM
     VHELAGEGML ILWSTSYLDE AEQCRDVLLM NEGELLYQGE PKALTQTMAG RSFLMTSPHE
     GNRKLLQRAL KLPQVSDGMI QGKSVRLILK KEATPDDIRH ADGMPEININ ETTPRFEDAF
     IDLLGGAGTS ESPLGAILHT VEGTPGETVI EAKELTKKFG DFAATDHVNF AVKRGEIFGL
     LGPNGAGKST TFKMMCGLLV PTSGQALVLG MDLKESSGKA RQHLGYMAQK FSLYGNLTVE
     QNLRFFSGVY GLRGRAQNEK ISRMSEAFGL KSIASHATDE LPLGFKQRLA LACSLMHEPD
     ILFLDEPTSG VDPLTRREFW LHINSMVEKG VTVMVTTHFM DEAEYCDRIG LVYRGKLIAS
     GTPDDLKAQS ANDEQPDPTM EQAFIQLIHD WDKEHSNE