YBHR_ECO57
ID YBHR_ECO57 Reviewed; 368 AA.
AC P0AFQ0; P75774; Q9ZBC6;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Probable multidrug ABC transporter permease YbhR {ECO:0000250|UniProtKB:P0AFP9};
GN Name=ybhR; OrderedLocusNames=Z1012, ECs0870;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Part of the ABC transporter complex YbhFSR that could be
CC involved in efflux of cefoperazone. Probably involved in the
CC translocation of the substrate across the membrane.
CC {ECO:0000250|UniProtKB:P0AFP9}.
CC -!- SUBUNIT: The complex is probably composed of two ATP-binding proteins
CC (YbhF) and two transmembrane proteins (YbhR and YbhS).
CC {ECO:0000250|UniProtKB:P0AFP9}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P0AFP9}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ABC-2 integral membrane protein family.
CC {ECO:0000305}.
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DR EMBL; AE005174; AAG55163.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB34293.1; -; Genomic_DNA.
DR PIR; F90737; F90737.
DR RefSeq; NP_308897.1; NC_002695.1.
DR RefSeq; WP_000469031.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; P0AFQ0; -.
DR SMR; P0AFQ0; -.
DR STRING; 155864.EDL933_0913; -.
DR EnsemblBacteria; AAG55163; AAG55163; Z1012.
DR EnsemblBacteria; BAB34293; BAB34293; ECs_0870.
DR GeneID; 66670936; -.
DR GeneID; 917635; -.
DR KEGG; ece:Z1012; -.
DR KEGG; ecs:ECs_0870; -.
DR PATRIC; fig|386585.9.peg.984; -.
DR eggNOG; COG0842; Bacteria.
DR HOGENOM; CLU_039483_8_3_6; -.
DR OMA; WGQELIE; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR000412; ABC_2_transport.
DR PRINTS; PR00164; ABC2TRNSPORT.
DR PROSITE; PS51012; ABC_TM2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..368
FT /note="Probable multidrug ABC transporter permease YbhR"
FT /id="PRO_0000183003"
FT TOPO_DOM 1..24
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..173
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 195..222
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..253
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..284
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..339
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 361..368
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P0AFP9"
FT DOMAIN 129..366
FT /note="ABC transmembrane type-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00442"
SQ SEQUENCE 368 AA; 41566 MW; CD9380B094EB86F2 CRC64;
MFHRLWTLIR KELQSLLREP QTRAILILPV LIQVILFPFA ATLEVTNATI AIYDEDNGEH
SVELTQRFAR ASAFTHVLLL KSPQEIRPTI DTQKALLLVR FPADFSRKLD TFQTAPLQLI
LDGRNSNSAQ IAANYLQQIV KNYQQELLEG KPKPNNSELV VRNWYNPNLD YKWFVVPSLI
AMITTIGVMI VTSLSVARER EQGTLDQLLV SPLTTWQIFI GKAVPALIVA TFQATIVLAI
GIWAYQIPFA GSLALFYFTM VIYGLSLVGF GLLISSLCST QQQAFIGVFV FMMPAILLSG
YVSPVENMPV WLQNLTWINP IRHFTDITKQ IYLKDASLDI VWNSLWPLLV ITATTGSAAY
AMFRRKVM
