YBHS_ECO57
ID YBHS_ECO57 Reviewed; 377 AA.
AC P0AFQ4; P75775;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Probable multidrug ABC transporter permease YbhS {ECO:0000250|UniProtKB:P0AFQ2};
GN Name=ybhS; OrderedLocusNames=Z1013, ECs0871;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Part of the ABC transporter complex YbhFSR that could be
CC involved in efflux of cefoperazone. Probably involved in the
CC translocation of the substrate across the membrane.
CC {ECO:0000250|UniProtKB:P0AFQ2}.
CC -!- SUBUNIT: The complex is probably composed of two ATP-binding proteins
CC (YbhF) and two transmembrane proteins (YbhR and YbhS).
CC {ECO:0000250|UniProtKB:P0AFQ2}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P0AFQ2}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ABC-2 integral membrane protein family.
CC {ECO:0000305}.
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DR EMBL; AE005174; AAG55164.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB34294.1; -; Genomic_DNA.
DR PIR; G90737; G90737.
DR PIR; H85587; H85587.
DR RefSeq; NP_308898.1; NC_002695.1.
DR RefSeq; WP_000070131.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; P0AFQ4; -.
DR SMR; P0AFQ4; -.
DR STRING; 155864.EDL933_0914; -.
DR EnsemblBacteria; AAG55164; AAG55164; Z1013.
DR EnsemblBacteria; BAB34294; BAB34294; ECs_0871.
DR GeneID; 66670935; -.
DR GeneID; 917608; -.
DR KEGG; ece:Z1013; -.
DR KEGG; ecs:ECs_0871; -.
DR PATRIC; fig|386585.9.peg.985; -.
DR eggNOG; COG0842; Bacteria.
DR HOGENOM; CLU_039483_8_3_6; -.
DR OMA; STWYLVP; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR000412; ABC_2_transport.
DR PROSITE; PS51012; ABC_TM2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..377
FT /note="Probable multidrug ABC transporter permease YbhS"
FT /id="PRO_0000183006"
FT TOPO_DOM 1..28
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..181
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..261
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..291
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..345
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 367..377
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P0AFQ2"
FT DOMAIN 145..375
FT /note="ABC transmembrane type-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00442"
SQ SEQUENCE 377 AA; 42060 MW; C25E40FA4586EEFD CRC64;
MSNPILSWRR VRALCVKETR QIVRDPSSWL IAVVIPLLLL FIFGYGINLD SSKLRVGILL
EQRSEAALDF THTMTGSPYI DATISDNRQE LIAKMQAGKI RGLVVIPVDF AEQMERANAT
APIQVITDGS EPNTANFVQG YVEGIWQIWQ MQRAEDNGQT FEPLIDVQTR YWFNPAAISQ
HFIIPGAVTI IMTVIGAILT SLVVAREWER GTMEALLSTE ITRTELLLCK LIPYYFLGML
AMLLCMLVSV FILGVPYRGS LLILFFISSL FLLSTLGMGL LISTITRNQF NAAQVALNAA
FLPSIMLSGF IFQIDSMPAV IRAVTYIIPA RYFVSTLQSL FLAGNIPVVL VVNVLFLIAS
AVMFIGLTWL KTKRRLD
