ID   YBHS_ECOL6              Reviewed;         377 AA.
AC   P0AFQ3; P75775;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Probable multidrug ABC transporter permease YbhS {ECO:0000250|UniProtKB:P0AFQ2};
GN   Name=ybhS; OrderedLocusNames=c0876;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Part of the ABC transporter complex YbhFSR that could be
CC       involved in efflux of cefoperazone. Probably involved in the
CC       translocation of the substrate across the membrane.
CC       {ECO:0000250|UniProtKB:P0AFQ2}.
CC   -!- SUBUNIT: The complex is probably composed of two ATP-binding proteins
CC       (YbhF) and two transmembrane proteins (YbhR and YbhS).
CC       {ECO:0000250|UniProtKB:P0AFQ2}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P0AFQ2}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the ABC-2 integral membrane protein family.
CC       {ECO:0000305}.
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DR   EMBL; AE014075; AAN79349.1; -; Genomic_DNA.
DR   RefSeq; WP_000070131.1; NC_004431.1.
DR   AlphaFoldDB; P0AFQ3; -.
DR   SMR; P0AFQ3; -.
DR   STRING; 199310.c0876; -.
DR   EnsemblBacteria; AAN79349; AAN79349; c0876.
DR   GeneID; 66670935; -.
DR   KEGG; ecc:c0876; -.
DR   eggNOG; COG0842; Bacteria.
DR   HOGENOM; CLU_039483_8_3_6; -.
DR   OMA; STWYLVP; -.
DR   BioCyc; ECOL199310:C0876-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR000412; ABC_2_transport.
DR   PROSITE; PS51012; ABC_TM2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..377
FT                   /note="Probable multidrug ABC transporter permease YbhS"
FT                   /id="PRO_0000183007"
FT   TOPO_DOM        1..28
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..181
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        203..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..261
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        283..291
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        313..345
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        367..377
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P0AFQ2"
FT   DOMAIN          145..375
FT                   /note="ABC transmembrane type-2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00442"
SQ   SEQUENCE   377 AA;  42060 MW;  C25E40FA4586EEFD CRC64;
     MSNPILSWRR VRALCVKETR QIVRDPSSWL IAVVIPLLLL FIFGYGINLD SSKLRVGILL
     EQRSEAALDF THTMTGSPYI DATISDNRQE LIAKMQAGKI RGLVVIPVDF AEQMERANAT
     APIQVITDGS EPNTANFVQG YVEGIWQIWQ MQRAEDNGQT FEPLIDVQTR YWFNPAAISQ
     HFIIPGAVTI IMTVIGAILT SLVVAREWER GTMEALLSTE ITRTELLLCK LIPYYFLGML
     AMLLCMLVSV FILGVPYRGS LLILFFISSL FLLSTLGMGL LISTITRNQF NAAQVALNAA
     FLPSIMLSGF IFQIDSMPAV IRAVTYIIPA RYFVSTLQSL FLAGNIPVVL VVNVLFLIAS
     AVMFIGLTWL KTKRRLD