ID   CATW_FELCA              Reviewed;         374 AA.
AC   Q9TST1;
DT   30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2002, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Cathepsin W;
DE            EC=3.4.22.-;
DE   Flags: Precursor;
GN   Name=CTSW;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lymphocyte;
RA   Kovacs E.M., Robinson W.F.;
RT   "FIV infection induces apoptosis and alters host gene expression.";
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May have a specific function in the mechanism or regulation
CC       of T-cell cytolytic activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:P56202}.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU10089, ECO:0000255|PROSITE-ProRule:PRU10090}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB59816.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AJ012326; CAB59816.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_001116343.1; NM_001122871.1.
DR   STRING; 9685.ENSFCAP00000005174; -.
DR   MEROPS; C01.037; -.
DR   GeneID; 100144390; -.
DR   KEGG; fca:100144390; -.
DR   CTD; 1521; -.
DR   eggNOG; KOG1542; Eukaryota.
DR   InParanoid; Q9TST1; -.
DR   OrthoDB; 1264766at2759; -.
DR   TreeFam; TF337736; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd02248; Peptidase_C1A; 1.
DR   InterPro; IPR033158; Cathepsin_W.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR025661; Pept_asp_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR039417; Peptidase_C1A_papain-like.
DR   InterPro; IPR013201; Prot_inhib_I29.
DR   PANTHER; PTHR12411:SF101; PTHR12411:SF101; 1.
DR   Pfam; PF08246; Inhibitor_I29; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00848; Inhibitor_I29; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Endoplasmic reticulum; Glycoprotein; Hydrolase; Protease;
KW   Reference proteome; Signal; Thiol protease; Zymogen.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..127
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000026325"
FT   CHAIN           128..374
FT                   /note="Cathepsin W"
FT                   /id="PRO_0000026326"
FT   ACT_SITE        153
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        291
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        329
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        205
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        347
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        150..191
FT                   /evidence="ECO:0000250"
FT   DISULFID        184..226
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   374 AA;  41644 MW;  12879CCF651CEC98 CRC64;
     MAITVYLSCL LVLSMAGLAQ GIKSSLRSQD PGPQPLELKQ AFTLFQIQYN RSYSNPEEYA
     RRLDIFAHNL AQAQQLEEED LGTAEFGVTP FSDLTEEEFG RLYGHRRMDG EAPKVGREVG
     SEEWGESVPP TCDWRKLDGV ISSVKKQESC SCCWAMAAAG NIEALWAIKY RQSVELSVQE
     LLDCGRCGDG CRGGFVWDAF ITVLNNSGLA SEKDYPFQGQ VKPHRCLAKK RTKVAWIQDF
     IMLPDNEQKI AWYLATQGPI TVTINMKLLK LYKKGVIEAT PTSCDPFLVD HSVLLVGFGK
     SESVADRRAG AAGAQPQSRR SIPFWILKNS WGTKWGXGGY FRLYRGNNTC GITKYPLTAR
     VDQPAKKRPV SCPP