YBN4_SCHPO
ID YBN4_SCHPO Reviewed; 325 AA.
AC O42888;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Uncharacterized oxidoreductase C8E4.04;
DE EC=1.-.-.-;
GN ORFNames=SPBC8E4.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
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DR EMBL; CU329671; CAA16997.1; -; Genomic_DNA.
DR PIR; T50378; T39169.
DR RefSeq; NP_596843.1; NM_001023865.2.
DR AlphaFoldDB; O42888; -.
DR SMR; O42888; -.
DR STRING; 4896.SPBC8E4.04.1; -.
DR MaxQB; O42888; -.
DR PaxDb; O42888; -.
DR EnsemblFungi; SPBC8E4.04.1; SPBC8E4.04.1:pep; SPBC8E4.04.
DR GeneID; 2541256; -.
DR KEGG; spo:SPBC8E4.04; -.
DR PomBase; SPBC8E4.04; -.
DR VEuPathDB; FungiDB:SPBC8E4.04; -.
DR eggNOG; KOG1577; Eukaryota.
DR HOGENOM; CLU_023205_0_0_1; -.
DR InParanoid; O42888; -.
DR PhylomeDB; O42888; -.
DR Reactome; R-SPO-193144; Estrogen biosynthesis.
DR Reactome; R-SPO-193368; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
DR Reactome; R-SPO-193775; Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
DR Reactome; R-SPO-193807; Synthesis of bile acids and bile salts via 27-hydroxycholesterol.
DR Reactome; R-SPO-196108; Pregnenolone biosynthesis.
DR Reactome; R-SPO-2162123; Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
DR Reactome; R-SPO-5365859; RA biosynthesis pathway.
DR Reactome; R-SPO-5652227; Fructose biosynthesis.
DR PRO; PR:O42888; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; ISO:PomBase.
DR GO; GO:0110095; P:cellular detoxification of aldehyde; ISS:PomBase.
DR Gene3D; 3.20.20.100; -; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; SSF51430; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Oxidoreductase; Reference proteome.
FT CHAIN 1..325
FT /note="Uncharacterized oxidoreductase C8E4.04"
FT /id="PRO_0000310309"
FT ACT_SITE 59
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 117
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT SITE 84
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000250"
SQ SEQUENCE 325 AA; 36629 MW; 68ED211F1E4D08D3 CRC64;
MSIKEFAKNA REAYFTLPNG DKIPSIGLGT WRSGKDETKN AVCAALKAGY RHIDTAHIYG
NEKEIGEGIR ESGVPRTDIW VTSKLWCNAH RAGLVPLALE KTLQDLNLEY IDAYLIHWPF
ALLSGPEELP RNEKGELIYE DVPIEETWQA MEELLETGKV RYIGISNFNN EYLDRVLKIA
KVKPTIHQME LHPYLPQTEY LEKHKKLQIH VSAYSPLANQ NDAYNSDISK LIEHKTLVDI
ANARGEGITP ANIAISWAVK RGTSVLPKSV NESRIVSNFL YIPLTDKEME AINNIGVVRR
FSHGKFAPKP MFVGLQDGTP KQTHA
