ID   YBP1_CANAL              Reviewed;         643 AA.
AC   Q5AKU3; A0A1D8PFT7;
DT   04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=CAP1-binding-protein {ECO:0000305};
GN   Name=YBP1 {ECO:0000303|PubMed:23706023};
GN   OrderedLocusNames=CAALFM_C113960WA; ORFNames=CaO19.12501, CaO19.5034;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CAP1, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=23706023; DOI=10.1089/ars.2013.5199;
RA   Patterson M.J., McKenzie C.G., Smith D.A., da Silva Dantas A., Sherston S.,
RA   Veal E.A., Morgan B.A., MacCallum D.M., Erwig L.P., Quinn J.;
RT   "Ybp1 and Gpx3 signaling in Candida albicans govern hydrogen peroxide-
RT   induced oxidation of the Cap1 transcription factor and macrophage escape.";
RL   Antioxid. Redox Signal. 19:2244-2260(2013).
CC   -!- FUNCTION: Involved in oxidative stress response and redox homeostasis.
CC       Required for hydrogen peroxide-induced oxidation and nuclear
CC       localization (activation) of CAP1. Functions probably in concert with
CC       GPX3, the actual CAP1 modifying enzyme. {ECO:0000269|PubMed:23706023}.
CC   -!- SUBUNIT: Interacts with CAP1. {ECO:0000269|PubMed:23706023}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23706023}.
CC   -!- DISRUPTION PHENOTYPE: Leads to decreased virulence in a Galleria
CC       mellonella model. {ECO:0000269|PubMed:23706023}.
CC   -!- SIMILARITY: Belongs to the YBP1 family. {ECO:0000305}.
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DR   EMBL; CP017623; AOW26997.1; -; Genomic_DNA.
DR   RefSeq; XP_722236.2; XM_717143.2.
DR   AlphaFoldDB; Q5AKU3; -.
DR   STRING; 237561.Q5AKU3; -.
DR   GeneID; 3636187; -.
DR   KEGG; cal:CAALFM_C113960WA; -.
DR   CGD; CAL0000191408; YBP1.
DR   VEuPathDB; FungiDB:C1_13960W_A; -.
DR   eggNOG; ENOG502RY9F; Eukaryota.
DR   HOGENOM; CLU_024514_0_0_1; -.
DR   InParanoid; Q5AKU3; -.
DR   OMA; LTYEIGW; -.
DR   OrthoDB; 348143at2759; -.
DR   PHI-base; PHI:3806; -.
DR   PRO; PR:Q5AKU3; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IBA:GO_Central.
DR   InterPro; IPR013877; YAP-bd/ALF4/Glomulin.
DR   InterPro; IPR040347; YBP1/2.
DR   PANTHER; PTHR28020; PTHR28020; 1.
DR   Pfam; PF08568; Kinetochor_Ybp2; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome; Stress response; Virulence.
FT   CHAIN           1..643
FT                   /note="CAP1-binding-protein"
FT                   /id="PRO_0000431936"
SQ   SEQUENCE   643 AA;  73954 MW;  7EC5151E65E38243 CRC64;
     MENLESGAQD ALQSKDFLSY STLLDIYLND PTKYSNEEKE QLLGHILTIL SENKQLTYEI
     GWDLPQLLIL YVDSDYEFNG PIRDSPGVYK ILKIFENLAI NGNHKELFLK SCELLNDLEL
     SQDEDIELLK RENFFEIKLY CVFELIDACL KKIHTLYPSR FLAMTVSSFN NLMFKLTKQH
     GSLGNYHFVM KRVYSFCRNY ISPPLPTNAK EMPQEELDKI VKDEEYLQRR LLTGFLTQVI
     YLANINGTEG YSIEHFSWLQ QQSKSKIKFV FERDGAFCDR FVELASSFDI DLLKCFQGFI
     TDSHKLLIGI DYKNKNKSED EIIELLFERV VVDYQKNVLT SIVDSDAKAI KDSIIGELIL
     FTHSIAGKKN FAKPTMSIHD SLVMTLRLII PQMVNPKFIN AGNHDVVVFW VWFALYQQQI
     INSKNLQLEI SYIPKVLLTT FFQCLLFIVI KSEGKPNFKY MLLTLLTKLL TLSPDTGYEF
     IKDSLNNCPY ESVYPSLIGV YKQLLLNEKW DVNSIELEKL NISSSSSNTP PKLPPRNGIK
     RKHFSLTNES LNDLVDLINN SSKNAFVEDN SKIDPSKLST IAAYLNLLVA IKKDPVIVEN
     KEKLTTLISS IENKIKSVKK SSQNQFELNA AGMLEITIER FNE