ID   YBWL_CAEEL              Reviewed;         364 AA.
AC   Q18347;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Putative protein C31H2.4;
GN   ORFNames=C31H2.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC       Note=Binds 1 Fe cation per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the 4HPPD family. {ECO:0000305}.
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DR   EMBL; FO080741; CCD66332.1; -; Genomic_DNA.
DR   PIR; T30084; T30084.
DR   RefSeq; NP_508875.1; NM_076474.1.
DR   AlphaFoldDB; Q18347; -.
DR   SMR; Q18347; -.
DR   BioGRID; 47934; 1.
DR   STRING; 6239.C31H2.4; -.
DR   EPD; Q18347; -.
DR   PaxDb; Q18347; -.
DR   PeptideAtlas; Q18347; -.
DR   EnsemblMetazoa; C31H2.4.1; C31H2.4.1; WBGene00016294.
DR   GeneID; 183101; -.
DR   KEGG; cel:CELE_C31H2.4; -.
DR   UCSC; C31H2.4; c. elegans.
DR   CTD; 183101; -.
DR   WormBase; C31H2.4; CE04132; WBGene00016294; -.
DR   eggNOG; KOG0638; Eukaryota.
DR   GeneTree; ENSGT00530000063474; -.
DR   HOGENOM; CLU_034004_3_1_1; -.
DR   InParanoid; Q18347; -.
DR   OMA; DHVVQNY; -.
DR   OrthoDB; 1087836at2759; -.
DR   PhylomeDB; Q18347; -.
DR   Reactome; R-CEL-8963684; Tyrosine catabolism.
DR   PRO; PR:Q18347; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00016294; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR   GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IBA:GO_Central.
DR   CDD; cd07250; HPPD_C_like; 1.
DR   CDD; cd08342; HPPD_N_like; 1.
DR   Gene3D; 3.10.180.10; -; 2.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR041735; 4OHPhenylPyrv_dOase_C.
DR   InterPro; IPR041736; 4OHPhenylPyrv_dOase_N.
DR   InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR   InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR   InterPro; IPR037523; VOC.
DR   PANTHER; PTHR11959; PTHR11959; 1.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   SUPFAM; SSF54593; SSF54593; 1.
DR   TIGRFAMs; TIGR01263; 4HPPD; 1.
DR   PROSITE; PS51819; VOC; 2.
PE   3: Inferred from homology;
KW   Iron; Metal-binding; Reference proteome; Repeat.
FT   CHAIN           1..364
FT                   /note="Putative protein C31H2.4"
FT                   /id="PRO_0000088415"
FT   DOMAIN          6..134
FT                   /note="VOC 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT   DOMAIN          161..320
FT                   /note="VOC 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT   BINDING         164
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         248
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         331
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   364 AA;  41456 MW;  599310F028F28E18 CRC64;
     MGSISAIHHI EFIVSNALQS AYWYCSGFGF EKFAEKITDE STSIALRNGT ARVIITSYNS
     QNIYTDQLIK HGDFIKDVSF RVDNLDAVLQ NLVENDIKVI QQSEVSTKDG LVRTATLLSE
     GGDVTHTLFE LGEFKGNFLP FFTPISNFEL FENIEKMPAI LMDHVVQNYP IGEMEAAADW
     YFKTMRLKRF WSVDDKVATS EFSAMTAWLL VNDDHTVQVT LAEGVKGRKG KSQIEEFINY
     HGGSGVQHFA LLVEDIISAV QIMKSRSVEF LTIPSQYYDN LEERLSKTNL IVKEDLKMIR
     ELNILMDFDE NGYLLQIFSK PLQDRPTLFI EIIQRANFKG FGAGNFKALF DAVEREQEKR
     GTLF