YC7C_SCHPO
ID YC7C_SCHPO Reviewed; 539 AA.
AC O94493;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2012, sequence version 2.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Uncharacterized esterase/lipase C417.12;
DE EC=3.1.-.-;
GN ORFNames=SPCC417.12;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000305}.
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DR EMBL; CU329672; CAA22658.2; -; Genomic_DNA.
DR PIR; T41347; T41347.
DR RefSeq; NP_588289.2; NM_001023279.2.
DR AlphaFoldDB; O94493; -.
DR SMR; O94493; -.
DR BioGRID; 275994; 4.
DR STRING; 4896.SPCC417.12.1; -.
DR ESTHER; schpo-SPCC417.12; Fungal_carboxylesterase_lipase.
DR MEROPS; S09.A99; -.
DR PaxDb; O94493; -.
DR EnsemblFungi; SPCC417.12.1; SPCC417.12.1:pep; SPCC417.12.
DR GeneID; 2539430; -.
DR KEGG; spo:SPCC417.12; -.
DR PomBase; SPCC417.12; -.
DR VEuPathDB; FungiDB:SPCC417.12; -.
DR eggNOG; KOG1516; Eukaryota.
DR HOGENOM; CLU_006586_17_1_1; -.
DR InParanoid; O94493; -.
DR OMA; MIMYSNA; -.
DR PRO; PR:O94493; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; ISM:PomBase.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR InterPro; IPR019819; Carboxylesterase_B_CS.
DR Pfam; PF00135; COesterase; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Nucleus; Reference proteome.
FT CHAIN 1..539
FT /note="Uncharacterized esterase/lipase C417.12"
FT /id="PRO_0000310361"
FT ACT_SITE 216
FT /note="Acyl-ester intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10039"
SQ SEQUENCE 539 AA; 61254 MW; 37E47C1B67EF03D3 CRC64;
MYESPIILGS KPCTLNIPGM GVLHGLTVLD ENGKEKCHRF TGIRYAKPPV GKLRWRRPVT
LEDGYDYSGD YNQFKTICPQ PFYNNRKNQV RNPDFKYDED CLFLNIWVPA GEKPAEGWPV
LYFIHGGWLQ VGNPLHYRQC DPQDLQADGS PAKFILVSPG HRLNLFGFLA GKELLEEDPK
SSNFGFWDQR LGLEWTYKHI ESFGGNKENI AVGGISAGSY SALFQLIYET YHPEANQIIK
RALLLSNGLS VQPKSVEESQ IQFNELAQKF GIPLELSSAE KLEKLRAIPF QDLADNILNL
RLHTFRAVTD GDFVNPNTFK DIYDGTFGKR IRDSGRELII GEVNNEHSIY ANTNPPKSKE
DLFNQVNNYY PEKVTKALLE LYPKVPDMED EKEYLAAIKA LFGSIVSDMQ VYASTRVLIN
GLVKGGVPLE KIYRYRIAFR GKFFDKYEPP ESLVPHAGDL GLWFYNVVDG ILPEEIPIYK
AWLKSYGEWM STGKTDWGTT KTEEYRLLDA DGTIKVVDDE KWDWGLKVGR TVAGVFGLN
