YC91_CAEEL
ID YC91_CAEEL Reviewed; 586 AA.
AC O01735; Q5W618;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Uncharacterized MFS-type transporter C09D4.1;
GN ORFNames=C09D4.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=O01735-1; Sequence=Displayed;
CC Name=b;
CC IsoId=O01735-2; Sequence=VSP_015554;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Feline
CC leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.
CC {ECO:0000305}.
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DR EMBL; FO080461; CCD63885.1; -; Genomic_DNA.
DR EMBL; FO080461; CCD63886.1; -; Genomic_DNA.
DR PIR; T29139; T29139.
DR RefSeq; NP_001020991.1; NM_001025820.3. [O01735-1]
DR RefSeq; NP_001020992.1; NM_001025821.2. [O01735-2]
DR AlphaFoldDB; O01735; -.
DR SMR; O01735; -.
DR BioGRID; 37661; 4.
DR STRING; 6239.C09D4.1a; -.
DR iPTMnet; O01735; -.
DR EPD; O01735; -.
DR PaxDb; O01735; -.
DR PeptideAtlas; O01735; -.
DR EnsemblMetazoa; C09D4.1a.1; C09D4.1a.1; WBGene00015632. [O01735-1]
DR EnsemblMetazoa; C09D4.1b.1; C09D4.1b.1; WBGene00015632. [O01735-2]
DR EnsemblMetazoa; C09D4.1b.2; C09D4.1b.2; WBGene00015632. [O01735-2]
DR EnsemblMetazoa; C09D4.1b.3; C09D4.1b.3; WBGene00015632. [O01735-2]
DR GeneID; 172203; -.
DR KEGG; cel:CELE_C09D4.1; -.
DR UCSC; C09D4.1a; c. elegans. [O01735-1]
DR CTD; 172203; -.
DR WormBase; C09D4.1a; CE27671; WBGene00015632; -. [O01735-1]
DR WormBase; C09D4.1b; CE37705; WBGene00015632; -. [O01735-2]
DR eggNOG; KOG2563; Eukaryota.
DR GeneTree; ENSGT01030000234625; -.
DR InParanoid; O01735; -.
DR OMA; AINWMST; -.
DR OrthoDB; 702737at2759; -.
DR PhylomeDB; O01735; -.
DR Reactome; R-CEL-189451; Heme biosynthesis.
DR Reactome; R-CEL-917937; Iron uptake and transport.
DR PRO; PR:O01735; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00015632; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0097037; P:heme export; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..586
FT /note="Uncharacterized MFS-type transporter C09D4.1"
FT /id="PRO_0000084858"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 513..533
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 536..556
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 17..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..111
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_015554"
SQ SEQUENCE 586 AA; 63826 MW; 7B9A474C869E812E CRC64;
MGGKAQFIRD FILKGPVRRT VPIEPVEPST SGSIAWTSSE SGSAHSSRVS SSPITPRKSA
ETEETLPTCL VRARGSSSAH SCSAATTSQQ SNRQSKEHRI GGIKKEEKPI EMGGGSSENG
GANGCSNGDN HHVLLMEKQE KIEPKVFRKR WVILVIFMFL SGSNGAQWIQ YSIIANIISD
YYKVSFQAVD WTSMIYMLTY ILFFIPAAWL LDKWGLRLSV LLGALGNCVG AWIKLLSTHP
DSFWVTFVGQ TIVGASQMFT LGIPPRLAAV WFGPDEVSRA CALGVFGNQL GIAVGFVLPP
LIVSNGSVEH VTYDLNTLFL GSAVLNTSIL ALVICFFTAR PAVPPSLAQV NALEEKTFDN
NFWGTLRKLM TSRDFVILFI TYGINTGVFY AISTLLSQMV LSVYPNETET VGYVGLLIVV
AGMAGSVVGG FILDKFKKFK LTTIMIYLFS FVGMLSFTLT IDLDSMVLVF INAALLGFFM
TGYLPIGFEF AAEITYPAAE GTTSGLLNAS AQIFGIALTW LMGIVMHGFG TFTSNIIMSS
CLVVGTILTC FIREDLKRQK AHSVQCTIPT SETQLTSCTL QQNEHF
