YCAD_ECO57
ID YCAD_ECO57 Reviewed; 382 AA.
AC Q8XEB7;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Uncharacterized MFS-type transporter YcaD;
GN Name=ycaD; OrderedLocusNames=Z1244, ECs0983;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. YcaD (TC
CC 2.A.1.26) family. {ECO:0000305}.
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DR EMBL; AE005174; AAG55385.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB34406.1; -; Genomic_DNA.
DR PIR; E85615; E85615.
DR PIR; G90751; G90751.
DR RefSeq; NP_309010.1; NC_002695.1.
DR RefSeq; WP_000109295.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; Q8XEB7; -.
DR SMR; Q8XEB7; -.
DR STRING; 155864.EDL933_1163; -.
DR EnsemblBacteria; AAG55385; AAG55385; Z1244.
DR EnsemblBacteria; BAB34406; BAB34406; ECs_0983.
DR GeneID; 917726; -.
DR KEGG; ece:Z1244; -.
DR KEGG; ecs:ECs_0983; -.
DR PATRIC; fig|386585.9.peg.1101; -.
DR eggNOG; COG0477; Bacteria.
DR HOGENOM; CLU_035018_1_2_6; -.
DR OMA; IGIGDHM; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.20; -; 2.
DR HAMAP; MF_01149; MFS_YcaD; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR023745; MFS_YcaD.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..382
FT /note="Uncharacterized MFS-type transporter YcaD"
FT /id="PRO_0000084890"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..44
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..101
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..130
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..156
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..234
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..269
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 312..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 346..347
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..382
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 382 AA; 41460 MW; 9C7DD6792878C856 CRC64;
MSTYTRPVML LLSGLLLLTL AIAVLNTLVP LWLAQEHMST WQVGVVSSSY FTGNLVGTLL
TGYVIKRIGF NRSYYLASFI FAAGCAGLGL MIGFWSWLAW RFVAGVGCAM IWVVVESALM
CSGTSRNRGR LLAAYMMVYY VGTFLGQLLV SKVSTELMSV LPWVTGLTLA GILPLLFTRV
LNQQAENHDS TSITSMLKLR QARLGVNGCI ISGIVLGSLY GLMPLYLNHK GVSNASIGFW
MAVLVSAGIL GQWPIGRLAD KFGRLLVLRV QVFVVILGSI AMLSQAAMAP ALFILGAAGF
TLYPVAMAWA CEKVEHHQLV AMNQALLLSY TVGSLLGPSF TAMLMQNFSD NLLFIMIASV
SFIYLLMLLR NAGHTPKPVA HV
