ID   YCAD_ECO5E              Reviewed;         382 AA.
AC   B5YT34;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Uncharacterized MFS-type transporter YcaD {ECO:0000255|HAMAP-Rule:MF_01149};
GN   Name=ycaD {ECO:0000255|HAMAP-Rule:MF_01149};
GN   OrderedLocusNames=ECH74115_1061;
OS   Escherichia coli O157:H7 (strain EC4115 / EHEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=444450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EC4115 / EHEC;
RX   PubMed=22135463; DOI=10.1073/pnas.1107176108;
RA   Eppinger M., Mammel M.K., Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Genomic anatomy of Escherichia coli O157:H7 outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20142-20147(2011).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01149}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01149}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. YcaD (TC
CC       2.A.1.26) family. {ECO:0000255|HAMAP-Rule:MF_01149}.
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DR   EMBL; CP001164; ACI35877.1; -; Genomic_DNA.
DR   RefSeq; WP_000109295.1; NC_011353.1.
DR   AlphaFoldDB; B5YT34; -.
DR   SMR; B5YT34; -.
DR   KEGG; ecf:ECH74115_1061; -.
DR   HOGENOM; CLU_035018_1_2_6; -.
DR   OMA; IGIGDHM; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   HAMAP; MF_01149; MFS_YcaD; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023745; MFS_YcaD.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..382
FT                   /note="Uncharacterized MFS-type transporter YcaD"
FT                   /id="PRO_1000137484"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01149"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01149"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01149"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01149"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01149"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01149"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01149"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01149"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01149"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01149"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01149"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01149"
SQ   SEQUENCE   382 AA;  41460 MW;  9C7DD6792878C856 CRC64;
     MSTYTRPVML LLSGLLLLTL AIAVLNTLVP LWLAQEHMST WQVGVVSSSY FTGNLVGTLL
     TGYVIKRIGF NRSYYLASFI FAAGCAGLGL MIGFWSWLAW RFVAGVGCAM IWVVVESALM
     CSGTSRNRGR LLAAYMMVYY VGTFLGQLLV SKVSTELMSV LPWVTGLTLA GILPLLFTRV
     LNQQAENHDS TSITSMLKLR QARLGVNGCI ISGIVLGSLY GLMPLYLNHK GVSNASIGFW
     MAVLVSAGIL GQWPIGRLAD KFGRLLVLRV QVFVVILGSI AMLSQAAMAP ALFILGAAGF
     TLYPVAMAWA CEKVEHHQLV AMNQALLLSY TVGSLLGPSF TAMLMQNFSD NLLFIMIASV
     SFIYLLMLLR NAGHTPKPVA HV