CAV1_CAEEL
ID CAV1_CAEEL Reviewed; 235 AA.
AC Q94051;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Caveolin-1;
GN Name=cav-1; ORFNames=T13F2.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Bristol N2;
RX PubMed=8999956; DOI=10.1074/jbc.272.4.2437;
RA Tang Z., Okamoto T., Boontrakulpoontawee P., Katada T., Otsuka A.J.,
RA Lisanti M.P.;
RT "Identification, sequence, and expression of an invertebrate caveolin gene
RT family from the nematode Caenorhabditis elegans. Implications for the
RT molecular evolution of mammalian caveolin genes.";
RL J. Biol. Chem. 272:2437-2445(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: May act as a scaffolding protein within caveolar membranes.
CC Interacts directly with G-protein alpha subunits and can functionally
CC regulate their activity.
CC -!- SUBUNIT: Homooligomer containing 14-16 monomers per oligomer.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}. Membrane, caveola
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC Note=Potential hairpin-like structure in the membrane. Membrane protein
CC of caveolae (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the caveolin family. {ECO:0000305}.
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DR EMBL; U66405; AAB48388.1; -; mRNA.
DR EMBL; Z81122; CAB03359.1; -; Genomic_DNA.
DR PIR; T24882; T24882.
DR RefSeq; NP_001255421.1; NM_001268492.1.
DR AlphaFoldDB; Q94051; -.
DR BioGRID; 42919; 5.
DR STRING; 6239.T13F2.8c; -.
DR iPTMnet; Q94051; -.
DR EPD; Q94051; -.
DR PaxDb; Q94051; -.
DR PeptideAtlas; Q94051; -.
DR EnsemblMetazoa; T13F2.8a.1; T13F2.8a.1; WBGene00000301.
DR GeneID; 177815; -.
DR KEGG; cel:CELE_T13F2.8; -.
DR UCSC; T13F2.8; c. elegans.
DR CTD; 177815; -.
DR WormBase; T13F2.8a; CE13633; WBGene00000301; cav-1.
DR eggNOG; ENOG502QUK5; Eukaryota.
DR GeneTree; ENSGT00950000183006; -.
DR HOGENOM; CLU_1220990_0_0_1; -.
DR InParanoid; Q94051; -.
DR OMA; QINCIRI; -.
DR OrthoDB; 1458714at2759; -.
DR PhylomeDB; Q94051; -.
DR Reactome; R-CEL-203641; NOSTRIN mediated eNOS trafficking.
DR Reactome; R-CEL-210991; Basigin interactions.
DR Reactome; R-CEL-4641262; Disassembly of the destruction complex and recruitment of AXIN to the membrane.
DR Reactome; R-CEL-8980692; RHOA GTPase cycle.
DR Reactome; R-CEL-9013026; RHOB GTPase cycle.
DR Reactome; R-CEL-9013106; RHOC GTPase cycle.
DR Reactome; R-CEL-9013148; CDC42 GTPase cycle.
DR Reactome; R-CEL-9013149; RAC1 GTPase cycle.
DR Reactome; R-CEL-9013405; RHOD GTPase cycle.
DR Reactome; R-CEL-9013407; RHOH GTPase cycle.
DR Reactome; R-CEL-9035034; RHOF GTPase cycle.
DR PRO; PR:Q94051; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00000301; Expressed in embryo and 4 other tissues.
DR ExpressionAtlas; Q94051; baseline and differential.
DR GO; GO:0005901; C:caveola; TAS:WormBase.
DR GO; GO:0005938; C:cell cortex; IDA:WormBase.
DR GO; GO:0060473; C:cortical granule; IDA:WormBase.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IDA:WormBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:WormBase.
DR GO; GO:0045121; C:membrane raft; HDA:WormBase.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:WormBase.
DR GO; GO:0030133; C:transport vesicle; IDA:WormBase.
DR GO; GO:0060090; F:molecular adaptor activity; ISS:WormBase.
DR GO; GO:0070836; P:caveola assembly; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IMP:WormBase.
DR GO; GO:0007265; P:Ras protein signal transduction; IGI:WormBase.
DR GO; GO:0046662; P:regulation of oviposition; IGI:WormBase.
DR InterPro; IPR001612; Caveolin.
DR InterPro; IPR031097; Caveolin-1_inver.
DR PANTHER; PTHR10844; PTHR10844; 1.
DR PANTHER; PTHR10844:SF21; PTHR10844:SF21; 1.
DR Pfam; PF01146; Caveolin; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Golgi apparatus; Lipoprotein; Membrane; Palmitate;
KW Reference proteome.
FT CHAIN 1..235
FT /note="Caveolin-1"
FT /id="PRO_0000144143"
FT TOPO_DOM 1..161
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT INTRAMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 29..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 234
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 235 AA; 26291 MW; F07B12DEB4D6F13A CRC64;
MSTEQDIKTE EQIPLTYAAV AAPTVQTEGE AVVAPEEPKP KKNWFTFGKK KAAPTDETNI
EEGGAPGDEP VKEKKEKKCW WSRCQKGEGE QKEENIAIGV DLVNRDANSM NNHVQLNFED
IFGEADSQHS WDCVWRLNHT VFTAVRLFIY RLVSLLALPF TIIFAIFFGL LASINVFIIV
PLGKLLSIPG TLLAKLWNWL IHAIFDPIAS AVGLIFSNFN IRKYGINQET TAPCV
