YCB2_YEAST
ID YCB2_YEAST Reviewed; 134 AA.
AC Q8J0M4; D6VR00;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=UPF0357 protein YCL012C;
DE Flags: Precursor;
GN OrderedLocusNames=YCL012C; ORFNames=YCL011C-A;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1574125; DOI=10.1038/357038a0;
RA Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA Sgouros J.G.;
RT "The complete DNA sequence of yeast chromosome III.";
RL Nature 357:38-46(1992).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-134.
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=12794934; DOI=10.1002/yea.996;
RA Zhang Z., Dietrich F.S.;
RT "Verification of a new gene on Saccharomyces cerevisiae chromosome III.";
RL Yeast 20:731-738(2003).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71 AND SER-74, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [5]
RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-86, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22106047; DOI=10.1002/pmic.201100166;
RA Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.;
RT "Sites of ubiquitin attachment in Saccharomyces cerevisiae.";
RL Proteomics 12:236-240(2012).
CC -!- SIMILARITY: Belongs to the UPF0357 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=X59720; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X59720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY178910; AAN86070.1; -; Genomic_DNA.
DR EMBL; BK006937; DAA07469.1; -; Genomic_DNA.
DR RefSeq; NP_976246.1; NM_001184672.1.
DR AlphaFoldDB; Q8J0M4; -.
DR SMR; Q8J0M4; -.
DR BioGRID; 37087; 2.
DR STRING; 4932.YCL012C; -.
DR iPTMnet; Q8J0M4; -.
DR MaxQB; Q8J0M4; -.
DR PaxDb; Q8J0M4; -.
DR PRIDE; Q8J0M4; -.
DR EnsemblFungi; YCL012C_mRNA; YCL012C; YCL012C.
DR GeneID; 2746859; -.
DR KEGG; sce:YCL012C; -.
DR SGD; S000029705; YCL012C.
DR VEuPathDB; FungiDB:YCL012C; -.
DR eggNOG; ENOG502S73R; Eukaryota.
DR HOGENOM; CLU_128832_0_1_1; -.
DR InParanoid; Q8J0M4; -.
DR OMA; NIRDGDS; -.
DR BioCyc; YEAST:G3O-29429-MON; -.
DR PRO; PR:Q8J0M4; -.
DR Proteomes; UP000002311; Chromosome III.
DR RNAct; Q8J0M4; protein.
DR InterPro; IPR018559; DUF2015.
DR PANTHER; PTHR28023; PTHR28023; 1.
DR Pfam; PF09435; DUF2015; 1.
PE 1: Evidence at protein level;
KW Isopeptide bond; Phosphoprotein; Reference proteome; Signal;
KW Ubl conjugation.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..134
FT /note="UPF0357 protein YCL012C"
FT /id="PRO_0000045281"
FT MOD_RES 71
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18407956"
FT MOD_RES 74
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18407956"
FT CROSSLNK 86
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0007744|PubMed:22106047"
SQ SEQUENCE 134 AA; 15588 MW; 90026ABBFC927130 CRC64;
MKSLFYLKLL LWVVLLSLCL LMAHRKTKVA DKFRALRSRI QLRFNRHIRL NDSFADDLEN
GLHSRNFDII SENSNDVRGG LDDVSKNEIK QIMENDNVDF DKARLLYMER KFGQNGIAPD
GTPIDPKAFT FDSR
