ID   YCCK_BACSU              Reviewed;         310 AA.
AC   P46905;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Uncharacterized oxidoreductase YccK;
DE            EC=1.-.-.-;
GN   Name=yccK; Synonyms=yzaE; OrderedLocusNames=BSU02770;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9274031; DOI=10.1099/00221287-143-8-2775;
RA   Kumano M., Tamakoshi A., Yamane K.;
RT   "A 32 kb nucleotide sequence from the region of the lincomycin-resistance
RT   gene (22 degrees-25 degrees) of the Bacillus subtilis chromosome and
RT   identification of the site of the lin-2 mutation.";
RL   Microbiology 143:2775-2782(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-268.
RC   STRAIN=BD99;
RX   PubMed=9106203; DOI=10.1046/j.1365-2958.1997.2951656.x;
RA   Cheng J., Guffanti A.A., Krulwich T.A.;
RT   "A two-gene ABC-type transport system that extrudes Na+ in Bacillus
RT   subtilis is induced by ethanol or protonophore.";
RL   Mol. Microbiol. 23:1107-1120(1997).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC       reductase 2 subfamily. {ECO:0000305}.
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DR   EMBL; AB000617; BAA22238.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12071.1; -; Genomic_DNA.
DR   EMBL; U30873; AAB53024.1; -; Genomic_DNA.
DR   PIR; B69755; B69755.
DR   RefSeq; NP_388159.1; NC_000964.3.
DR   RefSeq; WP_003246289.1; NZ_JNCM01000030.1.
DR   AlphaFoldDB; P46905; -.
DR   SMR; P46905; -.
DR   IntAct; P46905; 1.
DR   STRING; 224308.BSU02770; -.
DR   PaxDb; P46905; -.
DR   PRIDE; P46905; -.
DR   EnsemblBacteria; CAB12071; CAB12071; BSU_02770.
DR   GeneID; 938384; -.
DR   KEGG; bsu:BSU02770; -.
DR   PATRIC; fig|224308.179.peg.287; -.
DR   eggNOG; COG0667; Bacteria.
DR   InParanoid; P46905; -.
DR   OMA; FGCSTFP; -.
DR   PhylomeDB; P46905; -.
DR   BioCyc; BSUB:BSU02770-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..310
FT                   /note="Uncharacterized oxidoreductase YccK"
FT                   /id="PRO_0000070389"
FT   ACT_SITE        59
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         206..216
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   310 AA;  34800 MW;  C06BF4195D25C91C CRC64;
     MDQTRTLGKT KLKVKRIGFG ANAVGGHNLF PNLNDETGKD LVRTALDGGV NFIDTAFIYG
     LGRSEELIGE VVQERGVRNE LIIATKGAHK EVDGSIELDN SREFLRSEVE KSLKRLKTDY
     IDLYYVHFPD GKTPLAEVAG TLKELKDEGK IKAIGASNLD YQQLQDFNAD GYLEVFQAEY
     SLIQRDAEKE LLPYCEKQGI SFIPYFPLAS GLLTGKFTQD TVFDDFRKDK PQFQGETFIH
     NLKKVDKLKA VAEEKQADTA HVALAWLLTR PAIDAIIPGA KRPEQLQDNL KTLNIELTED
     EVNFISDIFK