YCCS_ECOLI
ID YCCS_ECOLI Reviewed; 717 AA.
AC P75870;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Inner membrane protein YccS;
GN Name=yccS; OrderedLocusNames=b0960, JW5128;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the YccS/YhfK family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U00096; AAC74046.2; -; Genomic_DNA.
DR EMBL; AP009048; BAA35718.2; -; Genomic_DNA.
DR PIR; G64836; G64836.
DR RefSeq; NP_415480.2; NC_000913.3.
DR AlphaFoldDB; P75870; -.
DR BioGRID; 4263155; 284.
DR DIP; DIP-11498N; -.
DR IntAct; P75870; 1.
DR STRING; 511145.b0960; -.
DR TCDB; 2.A.85.1.1; the aromatic acid exporter (arae) family.
DR PaxDb; P75870; -.
DR PRIDE; P75870; -.
DR EnsemblBacteria; AAC74046; AAC74046; b0960.
DR EnsemblBacteria; BAA35718; BAA35718; BAA35718.
DR GeneID; 947001; -.
DR KEGG; ecj:JW5128; -.
DR KEGG; eco:b0960; -.
DR PATRIC; fig|511145.12.peg.994; -.
DR EchoBASE; EB3485; -.
DR eggNOG; COG1289; Bacteria.
DR HOGENOM; CLU_013315_1_0_6; -.
DR InParanoid; P75870; -.
DR OMA; YFIAQDI; -.
DR PhylomeDB; P75870; -.
DR BioCyc; EcoCyc:G6495-MON; -.
DR PRO; PR:P75870; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR010019; Integral_membrane_YccS.
DR InterPro; IPR010020; Integral_membrane_YCCS_YHJK.
DR InterPro; IPR032692; YccS_N.
DR Pfam; PF12805; FUSC-like; 1.
DR TIGRFAMs; TIGR01666; YCCS; 1.
DR TIGRFAMs; TIGR01667; YCCS_YHJK; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..717
FT /note="Inner membrane protein YccS"
FT /id="PRO_0000168793"
FT TOPO_DOM 1..10
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..66
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..112
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..398
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 420..441
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 463..465
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 487..489
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 490..510
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 511..512
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 513..533
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 534..717
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 717 AA; 81668 MW; 8EC99A6850EFAD5A CRC64;
MLSPLLKRYT WNSAWLYYAR IFIALCGTTA FPWWLGDVKL TIPLTLGMVA AALTDLDDRL
AGRLRNLIIT LFCFFIASAS VELLFPWPWL FAIGLTLSTS GFILLGGLGQ RYATIAFGAL
LIAIYTMLGT SLYEHWYQQP MYLLAGAVWY NVLTLIGHLL FPVRPLQDNL ARCYEQLARY
LELKSRMFDP DIEDQSQAPL YDLALANGLL MATLNQTKLS LLTRLRGDRG QRGTRRTLHY
YFVAQDIHER ASSSHIQYQT LREHFRHSDV LFRFQRLMSM QGQACQQLSR CILLRQPYQH
DPHFERAFTH IDAALERMRD NGAPADLLKT LGFLLNNLRA IDAQLATIES EQAQALPHNN
DENELADDSP HGLSDIWLRL SRHFTPESAL FRHAVRMSLV LCFGYAIIQI TGMHHGYWIL
LTSLFVCQPN YNATRHRLKL RIIGTLVGIA IGIPVLWFVP SLEGQLVLLV ITGVLFFAFR
NVQYAHATMF ITLLVLLCFN LLGEGFEVAL PRVIDTLIGC AIAWAAVSYI WPDWQFRNLP
RMLERATEAN CRYLDAILEQ YHQGRDNRLA YRIARRDAHN RDAELASVVS NMSSEPNVTP
QIREAAFRLL CLNHTFTSYI SALGAHREQL TNPEILAFLD DAVCYVDDAL HHQPADEERV
NEALASLKQR MQQLEPRADS KEPLVVQQVG LLIALLPEIG RLQRQITQVP QETPVSA
