YCD3_SCHPO
ID YCD3_SCHPO Reviewed; 862 AA.
AC O94543;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Uncharacterized membrane protein C1322.03;
DE Flags: Precursor;
GN ORFNames=SPCC1322.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Golgi
CC apparatus membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane
CC protein {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the transient receptor potential (TRP) ion
CC channel family. {ECO:0000305}.
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DR EMBL; CU329672; CAA22856.1; -; Genomic_DNA.
DR PIR; T40934; T40934.
DR RefSeq; NP_588131.1; NM_001023121.2.
DR AlphaFoldDB; O94543; -.
DR BioGRID; 275643; 8.
DR STRING; 4896.SPCC1322.03.1; -.
DR TCDB; 1.A.4.9.4; the transient receptor potential ca(2+) channel (trp-cc) family.
DR MaxQB; O94543; -.
DR PaxDb; O94543; -.
DR EnsemblFungi; SPCC1322.03.1; SPCC1322.03.1:pep; SPCC1322.03.
DR GeneID; 2539071; -.
DR KEGG; spo:SPCC1322.03; -.
DR PomBase; SPCC1322.03; -.
DR VEuPathDB; FungiDB:SPCC1322.03; -.
DR eggNOG; ENOG502R2RV; Eukaryota.
DR HOGENOM; CLU_356839_0_0_1; -.
DR InParanoid; O94543; -.
DR OMA; FGWARVF; -.
DR PhylomeDB; O94543; -.
DR PRO; PR:O94543; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005262; F:calcium channel activity; IMP:PomBase.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IMP:PomBase.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR010308; TRP_C.
DR InterPro; IPR040241; TRP_Flc/Pkd2-like.
DR InterPro; IPR032800; TRP_N.
DR PANTHER; PTHR31145; PTHR31145; 1.
DR Pfam; PF06011; TRP; 1.
DR SMART; SM01320; TRP_N; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Golgi apparatus; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..862
FT /note="Uncharacterized membrane protein C1322.03"
FT /id="PRO_0000372620"
FT TOPO_DOM 26..61
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..187
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..230
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..329
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 351..372
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 394..404
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 426..457
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 481..483
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..503
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 504..514
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 536..545
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 546..566
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 567..862
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 668..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..852
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 862 AA; 97438 MW; 36C83CA6C6B88CA8 CRC64;
MKPRPYSVFL FLHIVFYSLL SAVNGSPSLD YFETCSNFVP RAGIPTFSPY AVIKNFDEVN
RMYYIQVVGN LSGVITIVGG NGSHIHAASV YSETYALGKL VTSNTTKLCD VVMDPHSFEV
PIKCPWAAGS AAFMVKVPFK STLSDYSKYE LTTLTTRVIV VDGTPEKNVI TCMKFGLSTT
LYYFYPVISY LVVVSLAYVS FSIIYALFLN PWTGSLDPFK SIFNFNMDPD ALRLTSLGFF
DFVQYLQFAV STAQVSVMFP KFYINIMAAL SWGTALFRFP IFSEPAEYQF ADFADLSVAS
SSYADYLPKS YGMYSFLDSI GIGTACWLPF LIVMVIYLFA ALFVALLVIF LKWLMSRIFN
ETIAETRWDT WSFIAGSLIR LYFLTYFPTV AYMSFQFVAP PTGYEIIPVL WFIFFGIFIP
VYLYMNLAFV EPSSKLLEDQ TYLHLFGSIY NSFREERVMF WIFPIAVQFM RGITVGVIGS
SGSAQLAIFF ILEVANVVAY AYVRPHFPQT SMNTLNTFIS TMRLITVILM IPLDPRLKVL
GISRDLLAYA ILFIHIMVCI LFLLLSTQRF MEVSARLLGA KSESKGVPLD RPFGWARVFG
INELRRRRLK DPYSNGNTMM FDHSTYNSNE MSVPLTPVSV CSNSLKKDGE AAPPKLFVQT
NCIPPVTQAS SLVPSKNNTA SSSSLMLDSP VTPSSPYSTS QGYSFYRPPK PKSSVRKRDM
DQLRALQLDF LNNKPNLLRH DVNYAVREAD VYHPHVDTSI DSLSQISSQP FEMRPTAIPP
PPKNAFQRAW QIVQSTAKSI WHSDPPKESE KGFVVLRSRP RPNLQKPLPQ LHIEPSRDEQ
YSMERKKTDD SLAESAWSIP HP
