CAV1_TAKRU
ID CAV1_TAKRU Reviewed; 181 AA.
AC Q9YGM8; Q8UW43;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Caveolin-1;
GN Name=cav1; Synonyms=cav-1;
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10025966; DOI=10.1016/s0014-5793(99)00011-3;
RA Cottage A., Clark M., Hawker K., Umrania Y., Wheller D., Bishop M.,
RA Elgar G.;
RT "Three receptor genes for plasminogen related growth factors in the genome
RT of the puffer fish Fugu rubripes.";
RL FEBS Lett. 443:370-374(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12917688; DOI=10.1038/nature01858;
RA Thomas J.W., Touchman J.W., Blakesley R.W., Bouffard G.G.,
RA Beckstrom-Sternberg S.M., Margulies E.H., Blanchette M., Siepel A.C.,
RA Thomas P.J., McDowell J.C., Maskeri B., Hansen N.F., Schwartz M.S.,
RA Weber R.J., Kent W.J., Karolchik D., Bruen T.C., Bevan R., Cutler D.J.,
RA Schwartz S., Elnitski L., Idol J.R., Prasad A.B., Lee-Lin S.-Q.,
RA Maduro V.V.B., Summers T.J., Portnoy M.E., Dietrich N.L., Akhter N.,
RA Ayele K., Benjamin B., Cariaga K., Brinkley C.P., Brooks S.Y., Granite S.,
RA Guan X., Gupta J., Haghighi P., Ho S.-L., Huang M.C., Karlins E.,
RA Laric P.L., Legaspi R., Lim M.J., Maduro Q.L., Masiello C.A.,
RA Mastrian S.D., McCloskey J.C., Pearson R., Stantripop S., Tiongson E.E.,
RA Tran J.T., Tsurgeon C., Vogt J.L., Walker M.A., Wetherby K.D.,
RA Wiggins L.S., Young A.C., Zhang L.-H., Osoegawa K., Zhu B., Zhao B.,
RA Shu C.L., De Jong P.J., Lawrence C.E., Smit A.F., Chakravarti A.,
RA Haussler D., Green P., Miller W., Green E.D.;
RT "Comparative analyses of multi-species sequences from targeted genomic
RT regions.";
RL Nature 424:788-793(2003).
CC -!- FUNCTION: May act as a positive regulator of T-cell coactivation. May
CC act as a scaffolding protein within caveolar membranes. Interacts
CC directly with G-protein alpha subunits and can functionally regulate
CC their activity (By similarity). {ECO:0000250|UniProtKB:Q03135}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250|UniProtKB:Q03135}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}. Membrane, caveola
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane raft
CC {ECO:0000250|UniProtKB:Q03135}. Note=Potential hairpin-like structure
CC in the membrane. Membrane protein of caveolae (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the caveolin family. {ECO:0000305}.
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DR EMBL; AJ010316; CAA09082.1; -; Genomic_DNA.
DR EMBL; AC090119; AAL40364.1; -; Genomic_DNA.
DR RefSeq; NP_001163827.1; NM_001170356.1.
DR AlphaFoldDB; Q9YGM8; -.
DR STRING; 31033.ENSTRUP00000043848; -.
DR GeneID; 100137154; -.
DR KEGG; tru:100137154; -.
DR CTD; 857; -.
DR eggNOG; ENOG502QUK5; Eukaryota.
DR HOGENOM; CLU_102582_0_0_1; -.
DR InParanoid; Q9YGM8; -.
DR OrthoDB; 1468974at2759; -.
DR TreeFam; TF315736; -.
DR Proteomes; UP000005226; Unplaced.
DR GO; GO:0005901; C:caveola; ISS:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:HGNC-UCL.
DR GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; ISS:HGNC-UCL.
DR GO; GO:0045121; C:membrane raft; ISS:HGNC-UCL.
DR GO; GO:0070836; P:caveola assembly; IEA:InterPro.
DR GO; GO:0031295; P:T cell costimulation; ISS:UniProtKB.
DR InterPro; IPR015504; CAV-1.
DR InterPro; IPR001612; Caveolin.
DR InterPro; IPR018361; Caveolin_CS.
DR PANTHER; PTHR10844; PTHR10844; 1.
DR PANTHER; PTHR10844:SF18; PTHR10844:SF18; 1.
DR Pfam; PF01146; Caveolin; 1.
DR PROSITE; PS01210; CAVEOLIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Golgi apparatus; Lipoprotein; Membrane; Palmitate;
KW Reference proteome.
FT CHAIN 1..181
FT /note="Caveolin-1"
FT /id="PRO_0000144135"
FT TOPO_DOM 1..107
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT INTRAMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..181
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 136
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 146
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 159
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CONFLICT 30
FT /note="Y -> N (in Ref. 2; AAL40364)"
FT /evidence="ECO:0000305"
FT CONFLICT 36
FT /note="Y -> N (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 38
FT /note="I -> S (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 60
FT /note="T -> K (in Ref. 2; AAL40364)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 181 AA; 20782 MW; 744FFD1018425D36 CRC64;
MTGGLRDGEK EEEFLHSPFI RKQGNIYKPY NKDMDYDILN EKSMEDVHTK EIDLVNRDPT
HLNDDVVKVD FEDVIAEPAG TYSFDGVWKA SFTTFTVTKY WCYRLLTALV GIPLALIWGI
FFAILSFIHI WAVVPCVKSY LIEIHCISRV YSICVHTFCD PLFEAMGKCL GGVRIRTSKE
V
