ID   CAV2_TAKRU              Reviewed;         162 AA.
AC   Q9YGM9;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Caveolin-2;
GN   Name=cav2; Synonyms=cav-2;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Cottage A.J.;
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12917688; DOI=10.1038/nature01858;
RA   Thomas J.W., Touchman J.W., Blakesley R.W., Bouffard G.G.,
RA   Beckstrom-Sternberg S.M., Margulies E.H., Blanchette M., Siepel A.C.,
RA   Thomas P.J., McDowell J.C., Maskeri B., Hansen N.F., Schwartz M.S.,
RA   Weber R.J., Kent W.J., Karolchik D., Bruen T.C., Bevan R., Cutler D.J.,
RA   Schwartz S., Elnitski L., Idol J.R., Prasad A.B., Lee-Lin S.-Q.,
RA   Maduro V.V.B., Summers T.J., Portnoy M.E., Dietrich N.L., Akhter N.,
RA   Ayele K., Benjamin B., Cariaga K., Brinkley C.P., Brooks S.Y., Granite S.,
RA   Guan X., Gupta J., Haghighi P., Ho S.-L., Huang M.C., Karlins E.,
RA   Laric P.L., Legaspi R., Lim M.J., Maduro Q.L., Masiello C.A.,
RA   Mastrian S.D., McCloskey J.C., Pearson R., Stantripop S., Tiongson E.E.,
RA   Tran J.T., Tsurgeon C., Vogt J.L., Walker M.A., Wetherby K.D.,
RA   Wiggins L.S., Young A.C., Zhang L.-H., Osoegawa K., Zhu B., Zhao B.,
RA   Shu C.L., De Jong P.J., Lawrence C.E., Smit A.F., Chakravarti A.,
RA   Haussler D., Green P., Miller W., Green E.D.;
RT   "Comparative analyses of multi-species sequences from targeted genomic
RT   regions.";
RL   Nature 424:788-793(2003).
CC   -!- FUNCTION: May act as a scaffolding protein within caveolar membranes.
CC       Interacts directly with G-protein alpha subunits and can functionally
CC       regulate their activity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}. Membrane, caveola
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC       Note=Potential hairpin-like structure in the membrane. Membrane protein
CC       of caveolae (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the caveolin family. {ECO:0000305}.
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DR   EMBL; AJ010316; CAA09081.1; -; Genomic_DNA.
DR   EMBL; AC090119; AAL40363.1; -; Genomic_DNA.
DR   RefSeq; NP_001163826.1; NM_001170355.1.
DR   AlphaFoldDB; Q9YGM9; -.
DR   STRING; 31033.ENSTRUP00000043846; -.
DR   Ensembl; ENSTRUT00000075396; ENSTRUP00000080415; ENSTRUG00000026846.
DR   GeneID; 100137153; -.
DR   KEGG; tru:100137153; -.
DR   CTD; 858; -.
DR   eggNOG; ENOG502RZYX; Eukaryota.
DR   GeneTree; ENSGT00950000183006; -.
DR   HOGENOM; CLU_102582_2_0_1; -.
DR   InParanoid; Q9YGM9; -.
DR   OMA; FMDDDAY; -.
DR   OrthoDB; 1468974at2759; -.
DR   TreeFam; TF315736; -.
DR   Proteomes; UP000005226; Chromosome 9.
DR   GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070836; P:caveola assembly; IEA:InterPro.
DR   InterPro; IPR033306; CAV-2.
DR   InterPro; IPR001612; Caveolin.
DR   InterPro; IPR018361; Caveolin_CS.
DR   PANTHER; PTHR10844; PTHR10844; 1.
DR   PANTHER; PTHR10844:SF3; PTHR10844:SF3; 1.
DR   Pfam; PF01146; Caveolin; 1.
DR   PROSITE; PS01210; CAVEOLIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Golgi apparatus; Membrane; Reference proteome.
FT   CHAIN           1..162
FT                   /note="Caveolin-2"
FT                   /id="PRO_0000144139"
FT   TOPO_DOM        1..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..162
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   162 AA;  18236 MW;  1D7CF4907D491253 CRC64;
     MGLEKEKLEC SIIMDEDEFN RSIEPILSKK ARLYSSAPDR DPHDINAQLK VGFEDVIAEP
     ASAHSFDRVW IGSSATFELV KFIFYRLLTT LLAVPAAFIL GVVFGVLSCI HIWLVMPVTR
     SFLMLLPSIQ VVWKSVTDMF ITPLFHSMGR SLSSIQVRTS DT