ID   CAV3_BOVIN              Reviewed;         151 AA.
AC   Q2KI43;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Caveolin-3;
GN   Name=CAV3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a scaffolding protein within caveolar membranes.
CC       Interacts directly with G-protein alpha subunits and can functionally
CC       regulate their activity. May also regulate voltage-gated potassium
CC       channels. Plays a role in the sarcolemma repair mechanism of both
CC       skeletal muscle and cardiomyocytes that permits rapid resealing of
CC       membranes disrupted by mechanical stress. Mediates the recruitment of
CC       CAVIN2 and CAVIN3 proteins to the caveolae.
CC       {ECO:0000250|UniProtKB:P51637, ECO:0000250|UniProtKB:P56539}.
CC   -!- SUBUNIT: Homooligomer. Interacts with DYSF. Interacts with DLG1 and
CC       KCNA5; forms a ternary complex. Interacts with DAG1 (via its C-
CC       terminal); the interaction prevents binding of DAG1 with DMD. Interacts
CC       with TRIM72. Interacts with MUSK; may regulate MUSK signaling.
CC       Interacts with BVES. Interacts with CAVIN1, CAVIN2 and CAVIN4.
CC       {ECO:0000250|UniProtKB:P51637, ECO:0000250|UniProtKB:P51638,
CC       ECO:0000250|UniProtKB:P56539}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}. Cell membrane
CC       {ECO:0000250|UniProtKB:P56538}; Peripheral membrane protein
CC       {ECO:0000250}. Membrane, caveola {ECO:0000250|UniProtKB:P51637};
CC       Peripheral membrane protein {ECO:0000250}. Cell membrane, sarcolemma
CC       {ECO:0000250|UniProtKB:P51637}. Note=Potential hairpin-like structure
CC       in the membrane. Membrane protein of caveolae (By similarity).
CC       {ECO:0000250}.
CC   -!- PTM: Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced
CC       internalization and desensitization of adrenergic receptor ABRD2.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the caveolin family. {ECO:0000305}.
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DR   EMBL; BC112776; AAI12777.1; -; mRNA.
DR   RefSeq; NP_001040023.1; NM_001046558.1.
DR   AlphaFoldDB; Q2KI43; -.
DR   SMR; Q2KI43; -.
DR   STRING; 9913.ENSBTAP00000030761; -.
DR   PaxDb; Q2KI43; -.
DR   Ensembl; ENSBTAT00000030791; ENSBTAP00000030761; ENSBTAG00000022699.
DR   GeneID; 615310; -.
DR   KEGG; bta:615310; -.
DR   CTD; 859; -.
DR   VEuPathDB; HostDB:ENSBTAG00000022699; -.
DR   VGNC; VGNC:26801; CAV3.
DR   eggNOG; ENOG502RYU9; Eukaryota.
DR   GeneTree; ENSGT00950000183006; -.
DR   HOGENOM; CLU_102582_0_0_1; -.
DR   InParanoid; Q2KI43; -.
DR   OMA; QYNINEE; -.
DR   OrthoDB; 1468974at2759; -.
DR   TreeFam; TF315736; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000022699; Expressed in cardiac ventricle and 58 other tissues.
DR   GO; GO:0005901; C:caveola; IDA:BHF-UCL.
DR   GO; GO:0016010; C:dystrophin-associated glycoprotein complex; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042383; C:sarcolemma; IDA:BHF-UCL.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0043014; F:alpha-tubulin binding; IEA:Ensembl.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:Ensembl.
DR   GO; GO:0071253; F:connexin binding; IBA:GO_Central.
DR   GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:Ensembl.
DR   GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR   GO; GO:0007015; P:actin filament organization; IEA:Ensembl.
DR   GO; GO:0006816; P:calcium ion transport; IEA:Ensembl.
DR   GO; GO:0055013; P:cardiac muscle cell development; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0070836; P:caveola assembly; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:Ensembl.
DR   GO; GO:0035995; P:detection of muscle stretch; IEA:Ensembl.
DR   GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR   GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR   GO; GO:0060347; P:heart trabecula formation; IEA:Ensembl.
DR   GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR   GO; GO:0046716; P:muscle cell cellular homeostasis; IEA:InterPro.
DR   GO; GO:0007520; P:myoblast fusion; IEA:Ensembl.
DR   GO; GO:0051926; P:negative regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0045792; P:negative regulation of cell size; IEA:Ensembl.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
DR   GO; GO:1900826; P:negative regulation of membrane depolarization during cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0051001; P:negative regulation of nitric-oxide synthase activity; IEA:Ensembl.
DR   GO; GO:0060299; P:negative regulation of sarcomere organization; IEA:Ensembl.
DR   GO; GO:0051647; P:nucleus localization; IEA:Ensembl.
DR   GO; GO:0001778; P:plasma membrane repair; IEA:Ensembl.
DR   GO; GO:0010831; P:positive regulation of myotube differentiation; IEA:Ensembl.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR   GO; GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IEA:Ensembl.
DR   GO; GO:0090279; P:regulation of calcium ion import; IEA:Ensembl.
DR   GO; GO:1901019; P:regulation of calcium ion transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0098909; P:regulation of cardiac muscle cell action potential involved in regulation of contraction; IEA:Ensembl.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
DR   GO; GO:1900825; P:regulation of membrane depolarization during cardiac muscle cell action potential; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   GO; GO:0051394; P:regulation of nerve growth factor receptor activity; IEA:Ensembl.
DR   GO; GO:1900744; P:regulation of p38MAPK cascade; IEA:Ensembl.
DR   GO; GO:0051896; P:regulation of protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:0038009; P:regulation of signal transduction by receptor internalization; IEA:Ensembl.
DR   GO; GO:0014819; P:regulation of skeletal muscle contraction; IEA:Ensembl.
DR   GO; GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0060373; P:regulation of ventricular cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR   GO; GO:0006641; P:triglyceride metabolic process; IEA:Ensembl.
DR   InterPro; IPR031091; CAV-3.
DR   InterPro; IPR001612; Caveolin.
DR   InterPro; IPR018361; Caveolin_CS.
DR   PANTHER; PTHR10844; PTHR10844; 1.
DR   PANTHER; PTHR10844:SF16; PTHR10844:SF16; 1.
DR   Pfam; PF01146; Caveolin; 1.
DR   PROSITE; PS01210; CAVEOLIN; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Golgi apparatus; Isopeptide bond; Membrane;
KW   Reference proteome; Ubl conjugation.
FT   CHAIN           1..151
FT                   /note="Caveolin-3"
FT                   /id="PRO_0000262912"
FT   TOPO_DOM        1..83
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..151
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          64..114
FT                   /note="Required for interaction with DAG1"
FT                   /evidence="ECO:0000250"
FT   CROSSLNK        38
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO3)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   151 AA;  17362 MW;  C68FCC1E58BA1023 CRC64;
     MMAEEHTDLE AQIVKDIHFK EIDLVNRDPK NINEDIVKVD FEDVIAEPVG TYSFDGVWKV
     SYTTFTVSKY WCYRLLSTLL GVPLALLWGF LFACISFCHI WAVVPCIKSY LIEIQCISHI
     YSLCIRTFCN PLFAALGQVC SNIKVMLRKE V