ID   CAVN4_XENLA             Reviewed;         359 AA.
AC   A2VDA9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Caveolae-associated protein 4;
DE   AltName: Full=Muscle-related coiled-coil protein;
DE   AltName: Full=Muscle-restricted coiled-coil protein;
GN   Name=cavin4; Synonyms=murc;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tail;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Induces rhoa activation and activates nppa transcription and
CC       myofibrillar organization through the rho/rock signaling pathway.
CC       {ECO:0000250|UniProtKB:A2AMM0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC       {ECO:0000250|UniProtKB:A2AMM0}. Cytoplasm
CC       {ECO:0000250|UniProtKB:A2AMM0}. Membrane, caveola
CC       {ECO:0000250|UniProtKB:A2AMM0}. Note=Localizes in the caveolae in a
CC       caveolin-dependent manner. {ECO:0000250|UniProtKB:A2AMM0}.
CC   -!- SIMILARITY: Belongs to the CAVIN family. {ECO:0000305}.
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DR   EMBL; BC129673; AAI29674.1; -; mRNA.
DR   RefSeq; NP_001091363.1; NM_001097894.1.
DR   AlphaFoldDB; A2VDA9; -.
DR   SMR; A2VDA9; -.
DR   DNASU; 100037205; -.
DR   GeneID; 100037205; -.
DR   KEGG; xla:100037205; -.
DR   CTD; 100037205; -.
DR   Xenbase; XB-GENE-877096; cavin4.S.
DR   OMA; GEKVMPP; -.
DR   OrthoDB; 991901at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 100037205; Expressed in muscle tissue and 5 other tissues.
DR   GO; GO:0005901; C:caveola; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   InterPro; IPR033299; Cavin4.
DR   InterPro; IPR026752; Cavin_fam.
DR   PANTHER; PTHR15240; PTHR15240; 1.
DR   PANTHER; PTHR15240:SF4; PTHR15240:SF4; 1.
DR   Pfam; PF15237; PTRF_SDPR; 1.
PE   2: Evidence at transcript level;
KW   Activator; Coiled coil; Cytoplasm; Developmental protein; Differentiation;
KW   Membrane; Myogenesis; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..359
FT                   /note="Caveolae-associated protein 4"
FT                   /id="PRO_0000325766"
FT   REGION          155..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          45..129
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        227..259
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..291
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..350
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   359 AA;  41019 MW;  0C6758647CAFBA1F CRC64;
     MDHETSSEKD RVNLNRLSMV SEDSVDHDAA LTIVAVLDKV ATIVDTVQAS QKRIEERHRE
     MEDAIKTIQI ELLKLAQAHS NTSYTVNKLL EKTRKVSSNV KDVKSRVDKQ SDQVQKVESK
     QEEMLRKNKF RVVIFQEDIE CPTKLTVAKQ SALDGNLRDD LYPPDDLSSD EEYSVQESRT
     SRLKKSGMKR INNIKKAFSK ESMQKTKQNF GNKVNRLRTR IVTPERRERL RQSGERLKTS
     GERFKQSIAK AAPKKEAFKI NIKKKGKQRT TAEGQEGGKE DETDSEEPTA KPISEEVTYT
     EVVTVKKKKK KNEENAELLL SQEDEKPSPV PEKTEKPLLK VEKKAESDEI PLVDINLSQ