CAV_DROER
ID CAV_DROER Reviewed; 328 AA.
AC B3P773;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 42.
DE RecName: Full=Telomere-binding protein cav {ECO:0000250|UniProtKB:Q95RV2};
DE AltName: Full=Protein caravaggio;
GN Name=cav {ECO:0000250|UniProtKB:Q95RV2}; ORFNames=GG11268;
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220;
RN [1] {ECO:0000312|EMBL:EDV53893.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14021-0224.01 {ECO:0000312|EMBL:EDV53893.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Binds to chromosome ends in a sequence-dependent manner and
CC is required for telomere capping. {ECO:0000250|UniProtKB:Q95RV2}.
CC -!- SUBUNIT: Interacts (via C-terminus) with Su(var)205 dimer (via hinge
CC and chromoshadow domain) and with moi to form the terminin, telomere-
CC capping, complex. Interacts with HP6, which is also part of the
CC terminin complex (By similarity). {ECO:0000250|UniProtKB:Q95RV2}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q95RV2}.
CC Chromosome, telomere {ECO:0000250|UniProtKB:Q95RV2}.
CC -!- MISCELLANEOUS: Multiple telomeric associations (TAs) in the same
CC metaphase spread often result in multicentric linear chromosomes that
CC resemble little 'trains' of chromosomes, hence the name 'caravaggio',
CC an Italian train.
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DR EMBL; CH954182; EDV53893.1; -; Genomic_DNA.
DR RefSeq; XP_001982023.1; XM_001981987.1.
DR AlphaFoldDB; B3P773; -.
DR STRING; 7220.FBpp0129814; -.
DR PRIDE; B3P773; -.
DR EnsemblMetazoa; FBtr0131322; FBpp0129814; FBgn0103569.
DR GeneID; 6555107; -.
DR KEGG; der:6555107; -.
DR eggNOG; ENOG502RN8H; Eukaryota.
DR HOGENOM; CLU_059636_0_0_1; -.
DR OMA; QINSESM; -.
DR OrthoDB; 1158010at2759; -.
DR PhylomeDB; B3P773; -.
DR ChiTaRS; cav; fly.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:EnsemblMetazoa.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000782; C:telomere cap complex; ISS:UniProtKB.
DR GO; GO:0042162; F:telomeric DNA binding; ISS:UniProtKB.
DR GO; GO:0016233; P:telomere capping; ISS:UniProtKB.
PE 3: Inferred from homology;
KW Chromosome; DNA-binding; Nucleus; Repeat; Telomere.
FT CHAIN 1..328
FT /note="Telomere-binding protein cav"
FT /id="PRO_0000379488"
FT REGION 107..320
FT /note="Required for binding to Su(var)205"
FT /evidence="ECO:0000250|UniProtKB:Q95RV2"
FT REGION 139..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 228..232
FT /note="Su(var)205-binding Pro-containing repeat 1"
FT /evidence="ECO:0000255"
FT MOTIF 281..287
FT /note="Su(var)205-binding Pro-containing repeat 2"
FT /evidence="ECO:0000255"
FT COMPBIAS 147..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 328 AA; 37632 MW; 51291BEDE5785598 CRC64;
MSDTQISSFL RKYLADEDRK IRAQFKESDP KNKLILWMHE KTRITEDDLK RPYTKDEVRE
LCLRTKVKVD MTAWNCLWEA KKRFDAKGRF ENKSEKFINR MYMKAVRRKM VQPYPEEYVA
QRREVIAAET KKFNISRLDR WQKQKSQNRS APESSSALVG HASQQDSQDN EAVETHEDQA
NTNRYSVSQM EPMARPVVSA SDLSGIGDDE DEQQQQQSEF QTEHTDCPET QMRCDQINSG
SLPMGLTNSE SAPDYYMFGT QLSTSVRPTS TQEADDQIAC PETETNESWV RCDQINSESM
SIGPSIDSEG NISLQNSGSE PIDVDSMA
