CAV_DROME
ID CAV_DROME Reviewed; 345 AA.
AC Q95RV2; B6UW60; B6UW70; B6UW72; B6UW76; B6UW79; B6UW88; O16046; O18360;
AC O18361; O18362; O18667; O18675; Q7KLS0; Q7KQE4; Q7KQE8; Q86BN7; Q9TVU4;
AC Q9U4P0; Q9VCB3;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Telomere-binding protein cav {ECO:0000303|PubMed:12510197};
DE AltName: Full=Anonymous fast evolving 1G5 {ECO:0000303|PubMed:12510197};
DE AltName: Full=HP1/ORC-associated protein {ECO:0000303|PubMed:11408576};
DE Short=HOAP p55 {ECO:0000303|PubMed:11408576};
DE AltName: Full=Protein caravaggio {ECO:0000303|PubMed:12510197};
GN Name=cav {ECO:0000303|PubMed:12510197};
GN Synonyms=anon fe 1G5 {ECO:0000303|PubMed:12510197},
GN anon1G5 {ECO:0000303|PubMed:10581279}, Hoap {ECO:0000303|PubMed:11408576},
GN IG5 {ECO:0000303|PubMed:9275195}; ORFNames=CG6219;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAB81482.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), NUCLEOTIDE SEQUENCE [GENOMIC DNA]
RP OF 28-293, AND VARIANTS THR-144; CYS-149; THR-154; ILE-198; TYR-236 AND
RP PHE-273.
RC STRAIN=Australia 2 {ECO:0000312|EMBL:AAB62252.1},
RC Australia 4 {ECO:0000312|EMBL:AAB62253.1},
RC Australia 5 {ECO:0000312|EMBL:AAB62254.1},
RC Canada {ECO:0000312|EMBL:AAB62255.1},
RC Canton-S {ECO:0000312|EMBL:AAB81482.1},
RC Cyprus {ECO:0000312|EMBL:AAB62256.1}, Irak {ECO:0000312|EMBL:AAB62257.1},
RC Italy {ECO:0000312|EMBL:AAB62258.1}, Japan {ECO:0000312|EMBL:AAB62259.1},
RC Peru {ECO:0000312|EMBL:AAB62260.1}, USA 1 {ECO:0000312|EMBL:AAB62265.1},
RC USA 2 {ECO:0000312|EMBL:AAB62266.1}, USA 3 {ECO:0000312|EMBL:AAB62267.1},
RC and USSR 1 {ECO:0000312|EMBL:AAB62268.1};
RX PubMed=9275195; DOI=10.1073/pnas.94.18.9746;
RA Schmid K.J., Tautz D.;
RT "A screen for fast evolving genes from Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:9746-9750(1997).
RN [2] {ECO:0000312|EMBL:AAN13988.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAN13988.2}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAL28662.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL28662.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5] {ECO:0000305, ECO:0000312|EMBL:ACI96383.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-149, AND VARIANT ASN-27.
RC STRAIN=MW11 {ECO:0000312|EMBL:ACI96383.1},
RC MW38 {ECO:0000312|EMBL:ACI96402.1}, MW56 {ECO:0000312|EMBL:ACI96406.1},
RC MW6 {ECO:0000312|EMBL:ACI96407.1}, MW63 {ECO:0000312|EMBL:ACI96408.1},
RC MW9 {ECO:0000312|EMBL:ACI96411.1}, NC301 {ECO:0000312|EMBL:ACI96388.1},
RC NC303 {ECO:0000312|EMBL:ACI96389.1}, NC304 {ECO:0000312|EMBL:ACI96390.1},
RC NC306 {ECO:0000312|EMBL:ACI96391.1}, NC319 {ECO:0000312|EMBL:ACI96392.1},
RC NC322 {ECO:0000312|EMBL:ACI96393.1}, NC336 {ECO:0000312|EMBL:ACI96394.1},
RC NC350 {ECO:0000312|EMBL:ACI96395.1}, NC357 {ECO:0000312|EMBL:ACI96396.1},
RC NC358 {ECO:0000312|EMBL:ACI96397.1}, NC359 {ECO:0000312|EMBL:ACI96398.1},
RC NC361 {ECO:0000312|EMBL:ACI96399.1}, NC362 {ECO:0000312|EMBL:ACI96400.1},
RC NC375 {ECO:0000312|EMBL:ACI96401.1}, NC390 {ECO:0000312|EMBL:ACI96403.1},
RC NC397 {ECO:0000312|EMBL:ACI96404.1}, NC399 {ECO:0000312|EMBL:ACI96405.1},
RC NC732 {ECO:0000312|EMBL:ACI96409.1}, and
RC NC774 {ECO:0000312|EMBL:ACI96410.1};
RX PubMed=18984573; DOI=10.1534/genetics.108.093807;
RA Anderson J.A., Gilliland W.D., Langley C.H.;
RT "Molecular population genetics and evolution of Drosophila meiosis genes.";
RL Genetics 181:177-185(2009).
RN [6] {ECO:0000305, ECO:0000312|EMBL:AAD45790.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-293, AND VARIANT THR-154.
RC STRAIN=Kenya 38 {ECO:0000312|EMBL:AAD45788.1},
RC Kenya 43 {ECO:0000312|EMBL:AAD45789.1}, and
RC Oregon-R {ECO:0000312|EMBL:AAD45790.1};
RX PubMed=10581279; DOI=10.1093/genetics/153.4.1717;
RA Schmid K.J., Nigro L., Aquadro C.F., Tautz D.;
RT "Large number of replacement polymorphisms in rapidly evolving genes of
RT Drosophila. Implications for genome-wide surveys of DNA polymorphism.";
RL Genetics 153:1717-1729(1999).
RN [7] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=11408576; DOI=10.1091/mbc.12.6.1671;
RA Shareef M.M., King C., Damaj M., Badagu R., Huang D.W., Kellum R.;
RT "Drosophila heterochromatin protein 1 (HP1)/origin recognition complex
RT (ORC) protein is associated with HP1 and ORC and functions in
RT heterochromatin-induced silencing.";
RL Mol. Biol. Cell 12:1671-1685(2001).
RN [8] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SU(VAR)205,
RP SU(VAR)205-BINDING MOTIF, AND MUTAGENESIS OF PRO-298.
RX PubMed=12826664; DOI=10.1074/jbc.m305262200;
RA Badugu R., Shareef M.M., Kellum R.;
RT "Novel Drosophila heterochromatin protein 1 (HP1)/origin recognition
RT complex-associated protein (HOAP) repeat motif in HP1/HOAP interactions and
RT chromocenter associations.";
RL J. Biol. Chem. 278:34491-34498(2003).
RN [9] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=12510197; DOI=10.1038/ncb902;
RA Cenci G., Siriaco G., Raffa G.D., Kellum R., Gatti M.;
RT "The Drosophila HOAP protein is required for telomere capping.";
RL Nat. Cell Biol. 5:82-84(2003).
RN [10] {ECO:0000305}
RP FUNCTION, AND INTERACTION WITH HP6.
RX PubMed=19190990; DOI=10.1007/s10577-008-9002-1;
RA Joppich C., Scholz S., Korge G., Schwendemann A.;
RT "Umbrea, a chromo shadow domain protein in Drosophila melanogaster
RT heterochromatin, interacts with Hip, HP1 and HOAP.";
RL Chromosome Res. 17:19-36(2009).
RN [11] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH MOI.
RX PubMed=19181850; DOI=10.1073/pnas.0812702106;
RA Raffa G.D., Siriaco G., Cugusi S., Ciapponi L., Cenci G., Wojcik E.,
RA Gatti M.;
RT "The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein
RT required for telomere protection.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:2271-2276(2009).
CC -!- FUNCTION: Binds to chromosome ends in a sequence-dependent manner and
CC is required for telomere capping. {ECO:0000269|PubMed:11408576,
CC ECO:0000269|PubMed:12510197, ECO:0000269|PubMed:12826664,
CC ECO:0000269|PubMed:19181850, ECO:0000269|PubMed:19190990}.
CC -!- SUBUNIT: Interacts (via C-terminus) with Su(var)205 dimer (via hinge
CC and chromoshadow domain) and with moi to form the terminin telomere-
CC capping complex. Interacts with HP6, which is also part of the terminin
CC complex. {ECO:0000269|PubMed:12826664, ECO:0000269|PubMed:19181850,
CC ECO:0000269|PubMed:19190990}.
CC -!- INTERACTION:
CC Q95RV2; Q7JWP6: HipHop; NbExp=7; IntAct=EBI-104820, EBI-103483;
CC Q95RV2; B7Z0L8: moi; NbExp=2; IntAct=EBI-104820, EBI-15755079;
CC Q95RV2; P05205: Su(var)205; NbExp=5; IntAct=EBI-104820, EBI-155532;
CC Q95RV2-3; Q9W396: HP1b; NbExp=4; IntAct=EBI-15131910, EBI-89630;
CC Q95RV2-3; Q9VR09: HP6; NbExp=4; IntAct=EBI-15131910, EBI-103911;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11408576,
CC ECO:0000269|PubMed:12510197, ECO:0000269|PubMed:12826664,
CC ECO:0000269|PubMed:19181850}. Chromosome, telomere
CC {ECO:0000269|PubMed:11408576, ECO:0000269|PubMed:12510197,
CC ECO:0000269|PubMed:12826664, ECO:0000269|PubMed:19181850}.
CC Note=Enriched at interphase, polytene and mitotic chromosome telomeres.
CC Localized predominantly at telomeres and diffusely throughout regions
CC of pericentric heterochromatin. {ECO:0000269|PubMed:11408576,
CC ECO:0000269|PubMed:12510197, ECO:0000269|PubMed:12826664,
CC ECO:0000269|PubMed:19181850}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=A {ECO:0000269|PubMed:10731132};
CC IsoId=Q95RV2-1; Sequence=Displayed;
CC Name=B {ECO:0000269|PubMed:9275195}; Synonyms=D
CC {ECO:0000269|PubMed:10731132};
CC IsoId=Q95RV2-2; Sequence=VSP_053126;
CC Name=E {ECO:0000269|PubMed:10731132};
CC IsoId=Q95RV2-3; Sequence=VSP_053127;
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC {ECO:0000269|PubMed:11408576}.
CC -!- DISRUPTION PHENOTYPE: Death at the larval/pupal boundary due to
CC extensive telomere-telomere fusions in larval brain cells.
CC {ECO:0000269|PubMed:12510197}.
CC -!- MISCELLANEOUS: Multiple telomeric associations (TAs) in the same
CC metaphase spread often result in multicentric linear chromosomes that
CC resemble little 'trains' of chromosomes, hence the name 'caravaggio',
CC an Italian train. {ECO:0000269|PubMed:12510197}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB62252.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB62253.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB62254.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB62255.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB62256.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB62257.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB62258.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB62259.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB62260.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB62265.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB62266.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB62267.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB62268.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF005851; AAB81482.1; -; mRNA.
DR EMBL; AF005865; AAB62252.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF005866; AAB62253.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF005867; AAB62254.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF005868; AAB62255.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF005869; AAB62256.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF005870; AAB62257.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF005871; AAB62258.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF005872; AAB62259.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF005873; AAB62260.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF005878; AAB62265.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF005879; AAB62266.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF005880; AAB62267.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF005881; AAB62268.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE014297; AAF56260.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN13988.2; -; Genomic_DNA.
DR EMBL; AE014297; AAN13989.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN13990.2; -; Genomic_DNA.
DR EMBL; AY061114; AAL28662.1; -; mRNA.
DR EMBL; FJ218758; ACI96383.1; -; Genomic_DNA.
DR EMBL; FJ218763; ACI96388.1; -; Genomic_DNA.
DR EMBL; FJ218764; ACI96389.1; -; Genomic_DNA.
DR EMBL; FJ218765; ACI96390.1; -; Genomic_DNA.
DR EMBL; FJ218766; ACI96391.1; -; Genomic_DNA.
DR EMBL; FJ218767; ACI96392.1; -; Genomic_DNA.
DR EMBL; FJ218768; ACI96393.1; -; Genomic_DNA.
DR EMBL; FJ218769; ACI96394.1; -; Genomic_DNA.
DR EMBL; FJ218770; ACI96395.1; -; Genomic_DNA.
DR EMBL; FJ218771; ACI96396.1; -; Genomic_DNA.
DR EMBL; FJ218772; ACI96397.1; -; Genomic_DNA.
DR EMBL; FJ218773; ACI96398.1; -; Genomic_DNA.
DR EMBL; FJ218774; ACI96399.1; -; Genomic_DNA.
DR EMBL; FJ218775; ACI96400.1; -; Genomic_DNA.
DR EMBL; FJ218776; ACI96401.1; -; Genomic_DNA.
DR EMBL; FJ218777; ACI96402.1; -; Genomic_DNA.
DR EMBL; FJ218778; ACI96403.1; -; Genomic_DNA.
DR EMBL; FJ218779; ACI96404.1; -; Genomic_DNA.
DR EMBL; FJ218780; ACI96405.1; -; Genomic_DNA.
DR EMBL; FJ218781; ACI96406.1; -; Genomic_DNA.
DR EMBL; FJ218782; ACI96407.1; -; Genomic_DNA.
DR EMBL; FJ218783; ACI96408.1; -; Genomic_DNA.
DR EMBL; FJ218784; ACI96409.1; -; Genomic_DNA.
DR EMBL; FJ218785; ACI96410.1; -; Genomic_DNA.
DR EMBL; FJ218786; ACI96411.1; -; Genomic_DNA.
DR EMBL; AF161784; AAD45788.1; -; Genomic_DNA.
DR EMBL; AF161785; AAD45789.1; -; Genomic_DNA.
DR EMBL; AF161786; AAD45790.1; -; Genomic_DNA.
DR RefSeq; NP_524477.3; NM_079753.4. [Q95RV2-1]
DR RefSeq; NP_732969.1; NM_170133.2. [Q95RV2-2]
DR RefSeq; NP_732970.1; NM_170134.2. [Q95RV2-2]
DR RefSeq; NP_732971.2; NM_170135.2. [Q95RV2-3]
DR AlphaFoldDB; Q95RV2; -.
DR BioGRID; 67812; 16.
DR DIP; DIP-48712N; -.
DR IntAct; Q95RV2; 5.
DR MINT; Q95RV2; -.
DR STRING; 7227.FBpp0083943; -.
DR PaxDb; Q95RV2; -.
DR DNASU; 42881; -.
DR EnsemblMetazoa; FBtr0084556; FBpp0083941; FBgn0026257. [Q95RV2-3]
DR EnsemblMetazoa; FBtr0084557; FBpp0083942; FBgn0026257. [Q95RV2-2]
DR EnsemblMetazoa; FBtr0084558; FBpp0083943; FBgn0026257. [Q95RV2-1]
DR EnsemblMetazoa; FBtr0084559; FBpp0083944; FBgn0026257. [Q95RV2-2]
DR GeneID; 42881; -.
DR KEGG; dme:Dmel_CG6219; -.
DR UCSC; CG6219-RA; d. melanogaster. [Q95RV2-1]
DR UCSC; CG6219-RB; d. melanogaster.
DR UCSC; CG6219-RE; d. melanogaster.
DR CTD; 42881; -.
DR FlyBase; FBgn0026257; cav.
DR VEuPathDB; VectorBase:FBgn0026257; -.
DR eggNOG; ENOG502RN8H; Eukaryota.
DR HOGENOM; CLU_059636_0_0_1; -.
DR InParanoid; Q95RV2; -.
DR PhylomeDB; Q95RV2; -.
DR SignaLink; Q95RV2; -.
DR BioGRID-ORCS; 42881; 0 hits in 1 CRISPR screen.
DR ChiTaRS; cav; fly.
DR GenomeRNAi; 42881; -.
DR PRO; PR:Q95RV2; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0026257; Expressed in egg cell and 25 other tissues.
DR ExpressionAtlas; Q95RV2; baseline and differential.
DR Genevisible; Q95RV2; DM.
DR GO; GO:0000775; C:chromosome, centromeric region; IDA:FlyBase.
DR GO; GO:0000781; C:chromosome, telomeric region; IDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000782; C:telomere cap complex; IDA:UniProtKB.
DR GO; GO:0042162; F:telomeric DNA binding; IMP:UniProtKB.
DR GO; GO:0016233; P:telomere capping; IMP:UniProtKB.
DR GO; GO:0000723; P:telomere maintenance; IMP:FlyBase.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW Repeat; Telomere.
FT CHAIN 1..345
FT /note="Telomere-binding protein cav"
FT /id="PRO_0000379489"
FT REGION 115..337
FT /note="Required for binding to Su(var)205"
FT /evidence="ECO:0000269|PubMed:12826664"
FT REGION 145..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 231..237
FT /note="Su(var)205-binding Pro-containing repeat 1"
FT /evidence="ECO:0000255, ECO:0000269|PubMed:12826664"
FT MOTIF 298..304
FT /note="Su(var)205-binding Pro-containing repeat 2"
FT /evidence="ECO:0000255, ECO:0000269|PubMed:12826664"
FT COMPBIAS 155..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..8
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:9275195"
FT /id="VSP_053126"
FT VAR_SEQ 2..6
FT /note="LLLLC -> VKE (in isoform E)"
FT /evidence="ECO:0000303|PubMed:10731132"
FT /id="VSP_053127"
FT VARIANT 27
FT /note="K -> N (in strain: NC350 and NC358)"
FT /evidence="ECO:0000269|PubMed:18984573"
FT VARIANT 144
FT /note="S -> T (in strain: Canton-S)"
FT /evidence="ECO:0000269|PubMed:9275195"
FT VARIANT 149
FT /note="W -> C (in strain: Canton-S)"
FT /evidence="ECO:0000269|PubMed:9275195"
FT VARIANT 154
FT /note="S -> T (in strain: Australia 2, Kenya 38, Kenya 43,
FT Peru and USA 3)"
FT /evidence="ECO:0000269|PubMed:10581279,
FT ECO:0000269|PubMed:9275195"
FT VARIANT 198
FT /note="M -> I (in strain: Australia 5)"
FT /evidence="ECO:0000269|PubMed:9275195"
FT VARIANT 236
FT /note="N -> Y (in strain: Japan)"
FT /evidence="ECO:0000269|PubMed:9275195"
FT VARIANT 273
FT /note="Y -> F (in strain: Australia 5 and USA 1)"
FT /evidence="ECO:0000269|PubMed:9275195"
FT MUTAGEN 298
FT /note="P->E: Prevents binding to HP1 hinge domain but no
FT effect on binding to HP1 chromoshadow domain."
FT /evidence="ECO:0000269|PubMed:12826664"
SQ SEQUENCE 345 AA; 39408 MW; FB325B88570FCF0E CRC64;
MLLLLCVNMS GTQMSAFLRK YLADEDKKIR AQFKESDPNN KLILWMHEKT RITEEDLARP
YTEDEVKELC LRTKVKVDMT AWNCLWEAKK RFEAKGRFVN KSERFINRMY MKAVRRKMVQ
PYPEEFVAQR REIVAAETKK QNISRLDRWQ KKKSQNLSAP ESSPDAHASS NDAVQSHEDQ
ANTNLSSLSQ MNFQVEAMAP PGVSSSDLSG IGDDEDEQQQ SGFQDENINR PETEINENSV
RCDPINLGRM RTGCINSQAN NSFRNTESDP DYYMFGTQLS TLVRPTSTQE PDDQVNCPET
EMNESWVRCD QINSESLSIG PSIDSEGTIT FQNTESEPID VTSIA
