ID   CAV_DROSE               Reviewed;         336 AA.
AC   B4HGK2;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Telomere-binding protein cav {ECO:0000250|UniProtKB:Q95RV2};
DE   AltName: Full=Protein caravaggio;
GN   Name=cav {ECO:0000250|UniProtKB:Q95RV2}; ORFNames=GM26573;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1] {ECO:0000312|EMBL:EDW43455.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25 {ECO:0000312|EMBL:EDW43455.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Binds to chromosome ends in a sequence-dependent manner and
CC       is required for telomere capping. {ECO:0000250|UniProtKB:Q95RV2}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with Su(var)205 dimer (via hinge
CC       and chromoshadow domain) and with moi to form the terminin, telomere-
CC       capping, complex. Interacts with HP6, which is also part of the
CC       terminin complex (By similarity). {ECO:0000250|UniProtKB:Q95RV2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q95RV2}.
CC       Chromosome, telomere {ECO:0000250|UniProtKB:Q95RV2}.
CC   -!- MISCELLANEOUS: Multiple telomeric associations (TAs) in the same
CC       metaphase spread often result in multicentric linear chromosomes that
CC       resemble little 'trains' of chromosomes, hence the name 'caravaggio',
CC       an Italian train.
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DR   EMBL; CH480815; EDW43455.1; -; Genomic_DNA.
DR   RefSeq; XP_002032469.1; XM_002032433.1.
DR   AlphaFoldDB; B4HGK2; -.
DR   STRING; 7238.B4HGK2; -.
DR   EnsemblMetazoa; FBtr0209558; FBpp0208050; FBgn0181426.
DR   GeneID; 6607705; -.
DR   KEGG; dse:6607705; -.
DR   HOGENOM; CLU_059636_0_0_1; -.
DR   OMA; QINSESM; -.
DR   PhylomeDB; B4HGK2; -.
DR   ChiTaRS; cav; fly.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:EnsemblMetazoa.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000782; C:telomere cap complex; ISS:UniProtKB.
DR   GO; GO:0042162; F:telomeric DNA binding; ISS:UniProtKB.
DR   GO; GO:0016233; P:telomere capping; ISS:UniProtKB.
PE   3: Inferred from homology;
KW   Chromosome; DNA-binding; Nucleus; Reference proteome; Repeat; Telomere.
FT   CHAIN           1..336
FT                   /note="Telomere-binding protein cav"
FT                   /id="PRO_0000379490"
FT   REGION          107..328
FT                   /note="Required for binding to Su(var)205"
FT                   /evidence="ECO:0000250|UniProtKB:Q95RV2"
FT   REGION          137..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          199..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          308..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           225..231
FT                   /note="Su(var)205-binding Pro-containing repeat 1"
FT                   /evidence="ECO:0000255"
FT   MOTIF           289..295
FT                   /note="Su(var)205-binding Pro-containing repeat 2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   336 AA;  38434 MW;  D38E6D7D0BCA8EB2 CRC64;
     MSGTQMSAFL RQYLADEDKK IRAQFKESDP NNKLILWMHE KTRITEEDLA RPYTEDEVKE
     LCLRTKVKVD MTAWNCLWEA KKRFEAKGRF VNKSERFINR MYVKAVRKKM VQPYPEEFVA
     QRREVVAAET KKHNISRLDR WQRKKTQNLS AQESSPARGA HLSFIDAMQT HEDQVNANLS
     SVSQINFQVE AIARPAVSSS DLSGIGDDED EHQQSEFQDE HINCPETAIN ENSVRCDPIN
     SGRMRTGCIN SQGNNNTESD PDYYMFGTQL SSLLRPTSTQ EPDDQVNCPE TEMNESWVRC
     DQINSESMSI GPSIDSEGTI TFQNSESEPI DVDSIA