CAV_DROSI
ID CAV_DROSI Reviewed; 336 AA.
AC B4QT24; B6UW58; O18418; O18419; O18668; Q9TVP2; Q9U4N4; Q9U4N5; Q9U4N6;
AC Q9U4N7; Q9U4N8; Q9U4N9;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 49.
DE RecName: Full=Telomere-binding protein cav {ECO:0000250|UniProtKB:Q95RV2};
DE AltName: Full=Protein caravaggio;
GN Name=cav {ECO:0000250|UniProtKB:Q95RV2}; ORFNames=GD21077;
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240;
RN [1] {ECO:0000312|EMBL:EDX14188.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [2] {ECO:0000305, ECO:0000312|EMBL:ACI96381.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-141.
RC STRAIN=C1674 {ECO:0000312|EMBL:ACI96387.1},
RC Md106 {ECO:0000312|EMBL:ACI96384.1}, Md199 {ECO:0000312|EMBL:ACI96385.1},
RC NewC {ECO:0000312|EMBL:ACI96382.1}, Sim {ECO:0000312|EMBL:ACI96381.1}, and
RC W501 {ECO:0000312|EMBL:ACI96386.1};
RX PubMed=18984573; DOI=10.1534/genetics.108.093807;
RA Anderson J.A., Gilliland W.D., Langley C.H.;
RT "Molecular population genetics and evolution of Drosophila meiosis genes.";
RL Genetics 181:177-185(2009).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAB62264.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-284, AND VARIANTS GLN-142; ARG-145;
RP ASN-146; SER-156; ASP-173; 182-VAL-SER-183 DEL; ILE-185; MET-185; ILE-192;
RP VAL-192; SER-193; GLN-212; VAL-220; GLN-238 AND ILE-265.
RC STRAIN=Colombia 32 {ECO:0000312|EMBL:AAB62261.1},
RC Mexico 2 {ECO:0000312|EMBL:AAB62262.1},
RC Mexico 23 {ECO:0000312|EMBL:AAB62263.1}, and
RC Zimbabwe 4 {ECO:0000312|EMBL:AAB62264.1};
RX PubMed=9275195; DOI=10.1073/pnas.94.18.9746;
RA Schmid K.J., Tautz D.;
RT "A screen for fast evolving genes from Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:9746-9750(1997).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAD45799.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-284, AND VARIANTS LEU-112; GLN-142;
RP ARG-145; SER-156; GLN-171; ALA-172; ASP-173; 182-VAL-SER-183 DEL; MET-185;
RP VAL-192; GLN-212; VAL-220; VAL-228; GLN-238; PRO-245; ILE-265 AND ILE-274.
RC STRAIN=Mexico 12 {ECO:0000312|EMBL:AAD45791.1},
RC Mexico 31 {ECO:0000312|EMBL:AAD45792.1},
RC North Carolina 19 {ECO:0000312|EMBL:AAD45793.1},
RC North Carolina 29 {ECO:0000312|EMBL:AAD45794.1},
RC Uruguay 25 {ECO:0000312|EMBL:AAD45795.1},
RC Zimbabwe 19 {ECO:0000312|EMBL:AAD45796.1},
RC Zimbabwe 21 {ECO:0000312|EMBL:AAD45797.1},
RC Zimbabwe 50 {ECO:0000312|EMBL:AAD45798.1},
RC Zimbabwe 70 {ECO:0000312|EMBL:AAD45799.1}, and
RC Zimbabwe 79 {ECO:0000312|EMBL:AAD45800.1};
RX PubMed=10581279; DOI=10.1093/genetics/153.4.1717;
RA Schmid K.J., Nigro L., Aquadro C.F., Tautz D.;
RT "Large number of replacement polymorphisms in rapidly evolving genes of
RT Drosophila. Implications for genome-wide surveys of DNA polymorphism.";
RL Genetics 153:1717-1729(1999).
CC -!- FUNCTION: Binds to chromosome ends in a sequence-dependent manner and
CC is required for telomere capping. {ECO:0000250|UniProtKB:Q95RV2}.
CC -!- SUBUNIT: Interacts (via C-terminus) with Su(var)205 dimer (via hinge
CC and chromoshadow domain) and with moi to form the terminin, telomere-
CC capping, complex. Interacts with HP6, which is also part of the
CC terminin complex (By similarity). {ECO:0000250|UniProtKB:Q95RV2}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q95RV2}.
CC Chromosome, telomere {ECO:0000250|UniProtKB:Q95RV2}.
CC -!- MISCELLANEOUS: Multiple telomeric associations (TAs) in the same
CC metaphase spread often result in multicentric linear chromosomes that
CC resemble little 'trains' of chromosomes, hence the name 'caravaggio',
CC an Italian train.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB62261.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB62262.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB62263.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAB62264.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CM000364; EDX14188.1; -; Genomic_DNA.
DR EMBL; FJ218756; ACI96381.1; -; Genomic_DNA.
DR EMBL; FJ218757; ACI96382.1; -; Genomic_DNA.
DR EMBL; FJ218759; ACI96384.1; -; Genomic_DNA.
DR EMBL; FJ218760; ACI96385.1; -; Genomic_DNA.
DR EMBL; FJ218761; ACI96386.1; -; Genomic_DNA.
DR EMBL; FJ218762; ACI96387.1; -; Genomic_DNA.
DR EMBL; AF005874; AAB62261.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF005875; AAB62262.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF005876; AAB62263.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF005877; AAB62264.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF161787; AAD45791.1; -; Genomic_DNA.
DR EMBL; AF161788; AAD45792.1; -; Genomic_DNA.
DR EMBL; AF161789; AAD45793.1; -; Genomic_DNA.
DR EMBL; AF161790; AAD45794.1; -; Genomic_DNA.
DR EMBL; AF161791; AAD45795.1; -; Genomic_DNA.
DR EMBL; AF161792; AAD45796.1; -; Genomic_DNA.
DR EMBL; AF161793; AAD45797.1; -; Genomic_DNA.
DR EMBL; AF161794; AAD45798.1; -; Genomic_DNA.
DR EMBL; AF161795; AAD45799.1; -; Genomic_DNA.
DR EMBL; AF161796; AAD45800.1; -; Genomic_DNA.
DR RefSeq; XP_016036011.1; XM_016177376.1.
DR AlphaFoldDB; B4QT24; -.
DR SMR; B4QT24; -.
DR STRING; 7240.B4QT24; -.
DR EnsemblMetazoa; FBtr0220987; FBpp0219479; FBgn0250857.
DR GeneID; 6729369; -.
DR HOGENOM; CLU_059636_0_0_1; -.
DR OMA; QINSESM; -.
DR PhylomeDB; B4QT24; -.
DR ChiTaRS; cav; fly.
DR Proteomes; UP000000304; Chromosome 3r.
DR Bgee; FBgn0250857; Expressed in embryo and 3 other tissues.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:EnsemblMetazoa.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000782; C:telomere cap complex; ISS:UniProtKB.
DR GO; GO:0042162; F:telomeric DNA binding; ISS:UniProtKB.
DR GO; GO:0016233; P:telomere capping; ISS:UniProtKB.
PE 3: Inferred from homology;
KW Chromosome; DNA-binding; Nucleus; Reference proteome; Repeat; Telomere.
FT CHAIN 1..336
FT /note="Telomere-binding protein cav"
FT /id="PRO_0000379491"
FT REGION 107..328
FT /note="Required for binding to Su(var)205"
FT /evidence="ECO:0000250|UniProtKB:Q95RV2"
FT REGION 198..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 225..231
FT /note="Su(var)205-binding Pro-containing repeat 1"
FT /evidence="ECO:0000255"
FT MOTIF 289..295
FT /note="Su(var)205-binding Pro-containing repeat 2"
FT /evidence="ECO:0000255"
FT VARIANT 112
FT /note="Q -> L (in strain: North Carolina 29)"
FT /evidence="ECO:0000269|PubMed:10581279"
FT VARIANT 142
FT /note="R -> Q (in strain: North Carolina 19, Zimbabwe 4 and
FT Zimbabwe 70)"
FT /evidence="ECO:0000269|PubMed:10581279,
FT ECO:0000269|PubMed:9275195"
FT VARIANT 145
FT /note="K -> R (in strain: Zimbabwe 4 and Zimbabwe 70)"
FT /evidence="ECO:0000269|PubMed:10581279,
FT ECO:0000269|PubMed:9275195"
FT VARIANT 146
FT /note="T -> N (in strain: Colombia 32)"
FT /evidence="ECO:0000269|PubMed:9275195"
FT VARIANT 156
FT /note="P -> S (in strain: North Carolina 19, Mexico 12 and
FT Zimbabwe 4)"
FT /evidence="ECO:0000269|PubMed:10581279,
FT ECO:0000269|PubMed:9275195"
FT VARIANT 171
FT /note="N -> Q (in strain: Zimbabwe 70 and Zimbabwe 79)"
FT /evidence="ECO:0000269|PubMed:10581279"
FT VARIANT 172
FT /note="E -> A (in strain: Zimbabwe 70 and Zimbabwe 79)"
FT /evidence="ECO:0000269|PubMed:10581279"
FT VARIANT 173
FT /note="V -> D (in strain: Mexico 2, Mexico 12, Mexico 23,
FT Mexico 31, North Carolina 19, North Carolina 29, Zimbabwe
FT 4, Zimbabwe 19, Zimbabwe 21, Zimbabwe 50, Zimbabwe 70,
FT Zimbabwe 79)"
FT /evidence="ECO:0000269|PubMed:10581279,
FT ECO:0000269|PubMed:9275195"
FT VARIANT 182..183
FT /note="Missing (in strain: Colombia 32, Mexico 2, Mexico
FT 23, Mexico 31, Zimbabwe 19, Zimbabwe 21, Zimbabwe 50)"
FT /evidence="ECO:0000269|PubMed:10581279,
FT ECO:0000269|PubMed:9275195"
FT VARIANT 185
FT /note="V -> I (in strain: Colombia 32)"
FT /evidence="ECO:0000269|PubMed:9275195"
FT VARIANT 185
FT /note="V -> M (in strain: Mexico 2, Mexico 23, Mexico 31,
FT Zimbabwe 19, Zimbabwe 21, Zimbabwe 50)"
FT /evidence="ECO:0000269|PubMed:10581279,
FT ECO:0000269|PubMed:9275195"
FT VARIANT 192
FT /note="M -> I (in strain: Zimbabwe 4)"
FT /evidence="ECO:0000269|PubMed:9275195"
FT VARIANT 192
FT /note="M -> V (in strain: Mexico 2, Mexico 23, Mexico 31,
FT Zimbabwe 19, Zimbabwe 21 and Zimbabwe 50)"
FT /evidence="ECO:0000269|PubMed:10581279,
FT ECO:0000269|PubMed:9275195"
FT VARIANT 193
FT /note="A -> S (in strain: Zimbabwe 4)"
FT /evidence="ECO:0000269|PubMed:9275195"
FT VARIANT 212
FT /note="H -> Q (in strain: Colombia 32, Mexico 12, North
FT Carolina 19, Zimbabwe 4 and Zimbabwe 70)"
FT /evidence="ECO:0000269|PubMed:10581279,
FT ECO:0000269|PubMed:9275195"
FT VARIANT 220
FT /note="E -> V (in strain: Mexico 2, Mexico 23, Mexico 31,
FT Zimbabwe 19, Zimbabwe 21 and Zimbabwe 50)"
FT /evidence="ECO:0000269|PubMed:10581279,
FT ECO:0000269|PubMed:9275195"
FT VARIANT 228
FT /note="A -> V (in strain: Mexico 12)"
FT /evidence="ECO:0000269|PubMed:10581279"
FT VARIANT 238
FT /note="P -> Q (in strain: Mexico 2, Mexico 12, Mexico 23,
FT Mexico 31, North Carolina 19, Zimbabwe 19, Zimbabwe 21,
FT Zimbabwe 50)"
FT /evidence="ECO:0000269|PubMed:10581279,
FT ECO:0000269|PubMed:9275195"
FT VARIANT 245
FT /note="R -> P (in strain: Mexico 12)"
FT /evidence="ECO:0000269|PubMed:10581279"
FT VARIANT 265
FT /note="M -> I (in strain: Mexico 2, Mexico 12, Mexico 23,
FT Mexico 31, Zimbabwe 4, Zimbabwe 19, Zimbabwe 21, Zimbabwe
FT 50, Zimbabwe 70, Zimbabwe 79)"
FT /evidence="ECO:0000269|PubMed:10581279,
FT ECO:0000269|PubMed:9275195"
FT VARIANT 274
FT /note="L -> I (in strain: Mexico 12)"
FT /evidence="ECO:0000269|PubMed:10581279"
SQ SEQUENCE 336 AA; 38417 MW; 009CA849F29EF56F CRC64;
MSGTQMSAFL RQYLADEDKK IRAQFKESDP NNKLILWMHE KTRITEEDLA RPYTEDEVKE
LCLRTKVKVD MTAWNCLWEA KKRFEAKGRF VNKSERFINR MYMKAVRKKM VQPYPEEFVA
QRREVVAAET KKHNISRLDR WRRKKTQNLS AQESSPARGA HASFIDAMQT NEVQVNANLS
SVSQVNFQVE AMARPAVSSS DLSGIGDDED EHQQSEFQDE HINCPETAIN ENSVRCDPIN
SGRMRTGCIN SQGNNNTESD PDYYMFGTQL SSLLRPTSTQ EPDDQVNCPE TEMNESWVRC
DQINSESMSI GPSIDSEGTI TFQNSESEPI DVDSIA
